A5075029467- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Advanced materials and composites
- Hip disorders and treatments
- Venous Thromboembolism Diagnosis and Management
- Titanium Alloys Microstructure and Properties
- Tracheal and airway disorders
- Orthopedic Surgery and Rehabilitation
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Hormonal and reproductive studies
- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- Parathyroid Disorders and Treatments
- Vascular anomalies and interventions
- Clinical Reasoning and Diagnostic Skills
- Hip and Femur Fractures
- Prostate Cancer Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Radioactive element chemistry and processing
- Intraperitoneal and Appendiceal Malignancies
- Peripheral Artery Disease Management
University Hospital of North Tees
2009-2024
North Tees and Hartlepool NHS Foundation Trust
2010-2024
Newcastle University
2010-2016
Orthopaedic Research
2010
Joint Replacement Institute
2010
Marymount University
2010
Rush University Medical Center
2010
University of Lisbon
2007
Early failure associated with adverse reactions to metal debris is an emerging problem after hip resurfacing but the exact mechanism unclear. We analysed our entire series of 660 metal-on-metal resurfacings (Articular Surface Replacement (ASR) and Birmingham Hip Resurfacing (BHR)) large-bearing ASR total replacements, establish associations debris-related failures. Clinical radiological outcomes, ion levels, explant studies lymphocyte transformation tests were performed. A 17 patients (3.4%)...
To describe the histopathology of localised adverse reactions to metal debris (ARMD) seen in association with failed on (MoM) hip arthroplasties. The nature aseptic lymphocytic vasculitis associated lesion (ALVAL) is investigated.Periprosthetic soft tissues biopsied at time revision from MoM arthroplasties January 2007 March 2011 were analysed. inflammatory cell response was categorised into perivascular cuffing (ALVAL), lymphoid aggregate formation or without germinal centres, metallosis...
This guideline is written as a reference document for clinicians presented with the challenge of managing paediatric patients differentiated thyroid carcinoma up to age 19 years. Care differs in key aspects from that adults, and there have been several recent developments care pathways this condition; has sought identify attend these areas. It addresses presentation, clinical assessment, diagnosis, management (both surgical medical), genetic counselling, follow-up prognosis affected...
We wished to investigate the influence of metal debris exposure on subsequent immune response and resulting soft-tissue injury following metal-on-metal (MoM) hip arthroplasty. Some reports have suggested that generated from head-neck taper junction is more destructive than equivalent doses bearing surfaces.We investigated source volume chromium (Cr) cobalt (Co) concentrations in corresponding blood synovial fluid samples observed agglomerated particle sizes excised tissues using multiple...
The identification of implant wear particles and non-implant related the characterization inflammatory responses in periprosthetic neo-synovial membrane, bone, synovial-like interface membrane (SLIM) play an important role for evaluation clinical outcome, correlation with radiological retrieval studies, understanding biological pathways contributing to failures joint arthroplasty. purpose this study is present a comprehensive histological particle algorithm (HPA) as practical guide at...
Objective Coeliac disease (CD) diagnosis generally depends on histological examination of duodenal biopsies. We present the first study analysing concordance in biopsies using digitised whole-slide images (WSIs). further investigate whether inclusion immunoglobulin A tissue transglutaminase (IgA tTG) and haemoglobin (Hb) data improves interobserver agreement diagnosis. Design undertook a large WSIs an entirely virtual reporting setting. Our was organised two phases: phase 1, 13 pathologists...
Aim To assess the diagnostic role of endobronchial ultrasound (EBUS) guided transbronchial fine needle aspiration (TBNA) cytology, in investigation mediastinal lymphadenopathy and masses, with emphasis on pathology, criteria for adequacy, use liquid based cytology (LBC). Methods In January 2008, EBUS TBNA was introduced staging lung cancers unexplained masses. Initially, material processed conventionally. May laboratory procured Cytyc T2000. Results 250 specimens (229 patients) were included...
Abstract The extraction of iron(III) from chloride solutions has been investigated using N,N′‐dimethyl‐N,N′‐diphenylhexylmalonamide (DMDΦ(H)MA), N,N′‐ dimethyl‐N,N′‐diphenyldodecylmalonamide (DMDΦ(D)MA), N,N′‐dimethyl‐N,N′‐dicyclohexylmalonamide (DMDCMA) and N,N′‐dimethyl‐N,N′‐dihexylmalonamide (DMDHMA). main aim this work was to investigate whether there is a relation between the chemical structure malonamides their behavior, try understand dependence metal mechanism on structural...
We have encountered patients who developed large joint fluid collections with massive elevations in chromium (Cr) and cobalt (Co) concentrations following metal-on-metal (MoM) hip arthroplasties. In some cases, retrieval analysis determined that these ion could not be explained simply by the wear rates of components. hypothesized effects may associated aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL).We examined influence ALVAL grade on synovial Co Cr adjustment for patient...
Abstract Introduction Several studies have reported significant cobalt(Co) and chromium(Cr) elevations in the blood of patients with total-knee-replacements (TKRs), histological signs metal sensitivity been up to 44% undergoing revision their TKRs. We carried out this investigation determine source quantity release Methodology identified all TKRs polished CoCr trays (N=59) [Vanguard=29, Attune=4 PFC=26]. These were analysed using peer-reviewed [coordinate-measuring-machine (CMM)] methodology...
We investigated the reliability of cobalt-chromium (CoCr) synovial joint fluid ratio (JFR) in identifying presence a severe aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) response and/or suboptimal taper performance (SOTP) following metal-on-metal (MoM) hip arthroplasty. then examined possibility that CoCr JFR may influence serum partitioning Co and Cr.For part A, we included all revision surgeries carried out at our unit with relevant data, including volumetric wear...
Objectives Several studies have reported elevated blood cobalt (Co) and chromium (Cr) concentrations in patients with total knee replacements (TKRs). Up to 44% of tissue samples taken from failed TKRs exhibit histological evidence metal sensitivity/ALVAL. In simulated conditions, particles contribute approximately 12% wear debris TKR. We carried out this investigation determine the source quantity release TKRs. Design Methods analysed 225 explanted fixed-bearing (Attune, Genesis II, NexGen,...
Objectives We identified an unusual pattern of backside deformation on polyethylene (PE) inserts contemporary total knee replacements (TKRs). The PE backside's margins were inferiorly deformed in TKRs with NexGen central-locking trays. This was significantly associated tray debonding. Furthermore, recent studies have shown high rate debonding PS TKRs. Subsequently, a field safety notice issued regarding the performance this particular device combination and Option has been withdrawn from...
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