A5058991304- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Carcinogens and Genotoxicity Assessment
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Sarcoma Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Soft tissue tumors and treatment
- Vascular Tumors and Angiosarcomas
- Lower Extremity Biomechanics and Pathologies
- Infectious Diseases and Tuberculosis
- Autoimmune and Inflammatory Disorders Research
- Knee injuries and reconstruction techniques
- Graphene and Nanomaterials Applications
- Systemic Lupus Erythematosus Research
- Orthopedic Surgery and Rehabilitation
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Spondyloarthritis Studies and Treatments
- Bone Tumor Diagnosis and Treatments
- Eosinophilic Disorders and Syndromes
Universitätsmedizin Greifswald
2021-2023
Universität Greifswald
2023
Weill Cornell Medicine
2022
Cornell University
2010-2022
Hospital for Special Surgery
2011-2021
Mount Sinai Medical Center
2004
Ospedale Martini
1996
Mount Sinai Hospital
1994
Occupational and environmental exposure to Co Cr has been previously linked a wide array of inflammatory degenerative conditions cancer. Recently, significant health concerns have raised by the high levels ions corrosion products released biomedical implants. Herein, we set analyze biological responses associated with toxicity. Histological, ultrastructural elemental analysis, performed on exposed patients reveal presence products, metallic wear debris metal at varying concentrations....
Glomerulonephritis is a major cause of morbidity in patients with systemic lupus erythematosus. Although substantial progress has been made the identification pathogenic triggers that result autoantibody production, little known about pathogenesis aggressive proliferative processes lead directly to irreversible glomerular damage and compromise renal function. In this study, we describe model polyinosinic: polycytidylic acid-accelerated nephritis NZB/W mice characterized by severe lesions de...
The study compared the OARSI osteoarthritis cartilage histopathology assessment system with biomechanical quality of human in vivo samples. In a prospective cohort study, 84 patients (100 knees) varus deformity knee were included between May, 2010 and January, 2012. Osteochondral samples underwent histologic analysis. dynamic modulus significantly (p < 0.001) decreased each advancing grade degeneration from Grade 0 (surface intact) to 4 (erosion). For aggregate modulus, there significant...
Trichloroethylene was administered by inhalation, 7 hours daily, 5 days weekly, for 8 weeks, at concentrations of 600, 100 and 0 ppm, to Sprague-Dawley rats Swiss mice; 104 weeks rats; 78 B6C3F1 mice 300, ppm. The animals were kept under observation until spontaneous death. In the experiments reported herein, 3768 studied. Under experimental conditions, trichloroethylene appears be carcinogenic in (particularly male mice). most relevant finding dose-related increased incidence Leydig cell...
Abstract Defective placentation and subsequent placental insufficiency lead to maternal fetal adverse pregnancy outcome, but their pathologic mechanisms are unclear, treatment remains elusive. The mildly hypertensive BPH/5 mouse recapitulates many features of human with pregnancies characterized by loss, growth restriction, abnormal development, defects in decidual arteries. Using this model, we show that recruitment neutrophils triggered complement activation at the maternal/fetal interface...
Increased failure rates due to metallic wear particle-associated adverse local tissue reactions (ALTR) is a significant clinical problem in resurfacing and total hip arthroplasty. Retrieved periprosthetic of 53 cases with corrosion/conventional particles from 285 revision operations for ALTR was selected nano-analyses. Three major classes implants associated ALTR, metal-on-metal arthroplasty (MoM HRA) large head replacement LHTHA) non-metal-on-metal dual modular neck (Non-MoM DMNTHA) were...
Adverse local tissue reaction (ALTR), characterized by a heterogeneous cellular inflammatory infiltrate and the presence of corrosion products in periprosthetic soft tissues, has been recognized as mechanism failure total hip replacement (THA). Different histological subtypes may have unique needs for longitudinal clinical follow-up complication rates after revision arthroplasty. The purpose this study was to describe patterns observed failed THA three different implant classes due ALTR...
A diet rich in saturated fat and carbohydrates causes low-grade chronic inflammation several organs, including the liver, ultimately driving nonalcoholic steatohepatitis. In this setting, environment-driven lipotoxicity glucotoxicity induce liver damage, which promotes dendritic cell activation generates a major histocompatibility complex class II (MHC-II) immunopeptidome enriched with peptides derived from proteins involved cellular metabolism, oxidative phosphorylation, stress responses....
OBJECTIVE. The objective of our study was to compare the frequency osseous and soft-tissue abnormalities in patients presenting with hip pain after resurfacing arthroplasty total (THA), correlate MRI findings histologic results, determine which are predictive aseptic lymphocytic vasculitis???associated lesions. MATERIALS AND METHODS. examinations metal-on-metal prostheses placed at (n = 31) or THA 29) were reviewed for osteolysis, synovitis, extracapsular disease, synovial pattern, mode...
We previously evaluated the three to ten-year results of 160 consecutive unicompartmental knee arthroplasties that had been performed by two surgeons in 147 patients with use cemented metal-backed Miller-Galante prosthesis. The average age at time index procedure was sixty-six years. purpose present study report updated this series after a mean duration follow-up twenty Sixty-two (seventy knees) were living, and seven lost follow-up. Eleven knees undergone conversion total arthroplasty, an...
Adverse local tissue reaction (ALTR) is characterized by periprosthetic soft inflammation composed of a mixed inflammatory cell infiltrate, extensive necrosis, and vascular changes. Multiple hip implant classes have been reported to result in ALTR, clinical differences may represent variation the response at cellular levels. The purpose this study was describe similarities structure, organization, composition conventional histology immunohistochemistry ALTR resulting from two common total...
The mixture of different metallic nanoparticles released from intended and unintended wearing orthopaedic implants such as the Co/Cr cup head, sleeves or tapers their interface with Ti stems in case hip prostheses are a leading cause adverse inflammatory responses cytotoxicity to host.This study assessed vitro cytotoxic effects three (Co, Cr Ti) separately combination on macrophages. vivo were also evaluated after peri-tibial soft tissue injection mice.The results demonstrated that Co, Cr,...
Abstract Objective To construct a humanized mouse model of systemic lupus erythematosus (SLE) that resembles the human disease in order to define pathophysiology and targets for treatments. Methods We infused peripheral blood mononuclear cells (PBMCs) from SLE patients into BALB‐ RAG‐2 −/− IL‐2Rγ double‐knockout (DKO) mice, which lack T cells, B natural killer cells. PBMCs 5 4 normal donors were intravenously/intraperitoneally at density 3–5 × 10 6 per animal nonirradiated 4–5‐week‐old mice....
Adverse local tissue reactions (ALTR) associated with tribocorrosion following total hip arthroplasty (THA) have become a significant clinical concern in recent years. In particular, implants featuring metal-on-metal bearing surfaces and modular femoral stems been reported to result elevated rates of ALTR. These tribocorrosion-related are characterized by marked necrosis lymphocytic infiltration, which contrasts sharply the macrophagic foreign body giant cell inflammation polyethylene wear...
The identification of implant wear particles and non-implant related the characterization inflammatory responses in periprosthetic neo-synovial membrane, bone, synovial-like interface membrane (SLIM) play an important role for evaluation clinical outcome, correlation with radiological retrieval studies, understanding biological pathways contributing to failures joint arthroplasty. purpose this study is present a comprehensive histological particle algorithm (HPA) as practical guide at...