A5019367526- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Advanced materials and composites
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Tribology and Wear Analysis
- Titanium Alloys Microstructure and Properties
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Nerve Injury and Rehabilitation
- Powder Metallurgy Techniques and Materials
- Infectious Diseases and Tuberculosis
- Dental Implant Techniques and Outcomes
- Bacterial biofilms and quorum sensing
- Diamond and Carbon-based Materials Research
- T-cell and B-cell Immunology
- Spine and Intervertebral Disc Pathology
- Surface Treatment and Residual Stress
- Monoclonal and Polyclonal Antibodies Research
- Spinal Fractures and Fixation Techniques
- Metal and Thin Film Mechanics
- Venomous Animal Envenomation and Studies
University Hospital Heidelberg
2016-2025
Heidelberg University
2016-2025
Orthopädische Universitätsklinik
2010-2023
Heidelberg University
2009-2013
Abstract Introduction CD4 + CD25 +/high CD127 low/- regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance. Data about the frequency of Tregs rheumatoid arthritis (RA) are contradictory and based on analysis blood (PB) synovial fluid (SF). Because exert their anti-inflammatory activity contact-dependent manner, membrane (SM) is crucial. Published reports regarding this matter lacking, so we investigated distribution phenotype concurrent samples SM, SF PB RA...
Metal-on-metal total hip resurfacing arthroplasty is increasingly being performed in young and active patients. Preclinical vitro testing of implants usually with use simulators, the serum metal ion concentration determined for purpose monitoring The goal this study was to characterize early running-in period vivo by characterizing levels.A well-functioning prosthesis implanted fifteen consecutive patients, concentrations these patients were then preoperatively at intervals during first...
Abstract Tetrahedral amorphous carbon (ta‐C) coatings have the potential to protect biomedical implants from wear and increase their service life. This study elucidates biocompatibility, mechanical properties, adhesion, resistance of ta‐C fabricated by physical vapor deposition on cobalt‐chromium‐molybdenum (CoCr) titanium (Ti64) alloys as well ultrahigh molecular weight polyethylene (UHMWPE). Satisfactory cytocompatibility is verified using contact angle surface tension measurements...
The Oxford mobile-bearing unicompartmental knee replacement (UKR) is an effective and safe treatment for osteoarthritis of the medial compartment. results in lateral compartment have been disappointing due to a high early rate dislocation bearing. A series using newly designed domed tibial component reported. first 50 consecutive UKRs patients with mean follow-up three years (2.0 4.3) were included. Clinical scores obtained prospectively Kaplan-Meier survival analysis was performed different...
Mechanical surface treatments have a long history in traditional engineering disciplines, such as the automotive or aerospace industries. Today, they are widely applied to metal components increase mechanical performance of these. However, their application medical field is rather rare. The present study aims compare potential relevant on high cycle fatigue (R = 0.1 for maximum 10 million cycles) Ti6Al4V standard alloy orthopedic, spinal, dental and trauma surgical implants: shot peening,...
Abstract Objectives Conventional dental implants inserted in the molar region of maxilla will reach into sinus maxillaris when alveolar ridge height is limited. When surgery performed without prior augmentation floor, primary stability implant important for successful osseointegration. This study aimed at identifying impact bone quality and quantity implantation site on a simulated bicortical placement. Materials methods In our vitro measurements, mineral density, total thickness overall...
Diamond-like carbon coatings may decrease implant wear, therefore, they are helping to reduce aseptic loosening and increase service life of total knee arthroplasties (TKAs). This two-part study addresses the development such for ultrahigh molecular weight polyethylene (UHMWPE) tibial inlays as well cobalt-chromium-molybdenum (CoCr) titanium (Ti64) alloy femoral components. While deposition a pure (a-C:H) tungsten-doped hydrogen-containing amorphous coating (a-C:H:W) detailed...
Abstract Background High-offset stems in cementless primary total hip arthroplasty (THA) have been potentially associated with early aseptic femoral loosening. This study aimed to evaluate the and secondary stability of a high-offset component under full weight-bearing conditions using model-based RSA, comparing it standard offset stem patients undergoing THA. Methods In this prospective, observational, single-center study, 42 end-stage osteoarthritis underwent THA either (SL-PLUS Standard)...
In total joint arthroplasty, wear and corrosion at modular taper junctions is an issue with clinical implications, as ions debris can lead to adverse tissue reactions. The quantification of the generated is, therefore, important measure judge performance such junctions. This applies pre-clinical in vitro investigations well retrospective retrieved implants. volume worn material be determined coordinate measuring machines (CMMs), which generally classified tactile optical systems. study aims...
Short stems have become more and popular for cementless total hip arthroplasty in the past few years. While conventional, uncemented straight primary (THA) shown high survival rates long term, it is not known whether short represent a reasonable alternative. As cortical hypertrophy has been reported stems, aim of this study was to determine radiographic prevalence assess clinical outcome frequently used short, curved stem. We retrospectively studied results our first 100 consecutive THAs (97...
The identification of implant wear particles and non-implant related the characterization inflammatory responses in periprosthetic neo-synovial membrane, bone, synovial-like interface membrane (SLIM) play an important role for evaluation clinical outcome, correlation with radiological retrieval studies, understanding biological pathways contributing to failures joint arthroplasty. purpose this study is present a comprehensive histological particle algorithm (HPA) as practical guide at...
Metal-on-metal implants are a special form of hip endoprostheses that despite many advantages can entail serious complications due to release wear particles from the implanted material. Metal presumably activate local host defence mechanisms, which causes persistent inflammatory response with destruction bone followed by loosening implant. To better characterize this and link inflammation degradation, generation proinflammatory osteoclast-inducing cytokines was analysed, as systemic T cell...
Revision total knee arthoplasty often requires modular implants to treat bone defects of varying severity. In some cases, it may not be clear which module size and implant combination (e.g. sleeve stem) should chosen for a specific defect. When balancing stability osseointegration against stress-shielding, is important choose an appropriate in order match the given level loss. Therefore, necessity stems less extensive tibial advantage different (lengths stiffnesses) with large metaphyseal...
Background and purpose — Uncemented acetabular components in primary total hip arthroplasty (THA) are commonly used today, but few studies have evaluated their survival into the second decade young active patients. We report on a minimum 10-year follow-up of an uncemented press-fit component that is still clinical use. Methods examined radiographic results our first 121 consecutive cementless THAs using cementless, grit-blasted, non-porous, titanium alloy cup (Allofit; Zimmer Inc., Warsaw,...