A5077818082- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Alzheimer's disease research and treatments
- Advanced materials and composites
- Inorganic Fluorides and Related Compounds
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Inorganic Chemistry and Materials
- Crystallization and Solubility Studies
- Catalysis and Oxidation Reactions
- Synthesis and characterization of novel inorganic/organometallic compounds
- Ionic liquids properties and applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Body Image and Dysmorphia Studies
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- 14-3-3 protein interactions
- Chemical Synthesis and Reactions
- Neuroscience and Neuropharmacology Research
- Monoclonal and Polyclonal Antibodies Research
- Crystal Structures and Properties
- Fluorine in Organic Chemistry
- Consumer Retail Behavior Studies
- Obsessive-Compulsive Spectrum Disorders
University Hospital Heidelberg
2011-2025
Heidelberg University
2009-2025
University Hospital of Basel
2017
University Hospital of Zurich
2016
TU Dresden
2012-2016
University of Applied Sciences Upper Austria
2016
Pfizer (Germany)
2012-2014
Humboldt-Universität zu Berlin
1997-2012
Innovent
2012
University Hospital Cologne
2010
Nicastrin and presenilin are two major components of the γ-secretase complex, which executes intramembrane proteolysis type I integral membrane proteins such as amyloid precursor protein (APP) Notch. is synthesized in fibroblasts neurons an endoglycosidase-H-sensitive glycosylated (immature nicastrin) then modified by complex glycosylation Golgi apparatus sialylation trans-Golgi network (mature nicastrin). These modifications not observed with exogenously overexpressed nicastrin. Under...
The purpose of this study was to conduct a randomized trial comparing the efficacy group cognitive-behavioral therapy (CBT) intervention designed for treatment compulsive buying disorder waiting list control (WLC) group.Thirty-one patients with problems according criteria developed by McElroy et al. were assigned receive active (12 weekly sessions and 6-month follow-up) 29 WLC group. specifically aimed at interrupting controlling problematic behavior, establishing healthy purchasing...
Our aim was to investigate the effect of TiF<sub>4</sub> solutions on mineral loss enamel and dentine in vitro. Samples were fluoridated 1 × 5 min per day with 1.64% w/v or 2.2% NaF solutions, each a pH 1.2, then subjected cyclic de- remineralization procedure for days. Demineralization performed 6 10 citric acid (pH 2.3). In controls no fluoridation performed. Mineral content determined by longitudinal microradiography. Enamel markedly reduced both fluoride but significantly...
Cleavage of the amyloid precursor protein (APP) within amyloid-beta (Abeta) sequence by alpha-secretase prevents formation toxic Abeta peptides. It has been shown that disintegrin-metalloproteinases ADAM10 and TACE (ADAM17) act as alpha-secretases stimulate generation a soluble neuroprotective fragment APP, APPsalpha. Here we demonstrate related APP-like 2 (APLP2), which to be essential for development survival mice, is also substrate both proteinases. Overexpression either or in HEK293...
In total joint arthroplasty, wear and corrosion at modular taper junctions is an issue with clinical implications, as ions debris can lead to adverse tissue reactions. The quantification of the generated is, therefore, important measure judge performance such junctions. This applies pre-clinical in vitro investigations well retrospective retrieved implants. volume worn material be determined coordinate measuring machines (CMMs), which generally classified tactile optical systems. study aims...
Abstract In cystic fibrosis (CF) patients, chronic airway infection by Pseudomonas leads to progressive lung destruction ultimately requiring transplantation (LT). Following LT, CF-adapted strains, potentially originating from the sinuses, may seed allograft leading infections and reduced survival. We investigated whether populations invade donor microbiota adapt non-CF allograft. collected sequential isolates samples a CF-lung transplant recipient during two years, followed dynamics of...
Light-controlled NO delivery systems promise new applications in phototherapies. For this purpose, a ruthenium nitrosyl complex [(2)Ru(NO)(Cl)] with the novel ligand N,N′-(1,2-phenylene)bis(1-methyl-1H-imidazole-2-carboxamide) (2) has been synthesised and characterised detail. The photoactive {Ru–NO}6 released DMSO upon exposure to low-intensity UV-A light (λ = 366 nm). In order create an applicable system water-insoluble was embedded into poly(L-lactide-co-D/L-lactide) nanofibrous...
Abstract Polyethylene wear is one of the major factors influencing survivorship joint replacements. Depending on number, size and morphology polyethylene particles, biological responses periprosthetic soft tissue in terms inflammatory processes can occur, leading to loosening implant. Various parameters are used analyze which usually determined by examining scanning electron microscopy (SEM) images with a particle analysis program. In this study, three different software solutions for...
Mild but efficient treatments of autoimmune diseases are urgently required. One such therapy, long-term maintenance chronic delayed type hypersensitivity, has been described for alopecia areata (AA), a hair follicle-affecting disease. The molecular mechanisms underlying the therapeutic efficacy unknown, may involve myeloid-derived suppressor cells (MDSCs). AA-affected mice were treated with squaric acid dibutyl ester (SADBE). immunoreactivity SADBE-treated AA lymphocytes and co-cultured...
Tribocorrosion in taper junctions of retrieved anatomic shoulder arthroplasty implants was evaluated. A comparison the tribocorrosion between cobalt-chromium and titanium alloy stems conducted observations were correlated with individual's clinical data. Adverse effects caused by metal debris subsequent elevated serum ion levels are frequently reported total hip arthroplasty. In arthroplasty, to date only a small number retrieval analyses available even fewer address issue at junctions. 36...
Wear of total hip replacements has been the focus many studies. However, frictional effects, such as high loading on intramodular connections or interface to bone, well friction associated squeaking have recently increased interest about amount that is generated during daily activities. The aim this study was thus establish and validate a three-dimensional setup under standardized conditions.A standard simulator modified allow for precision measurements small effects in articulation....
Recent studies have reported a considerable number of non-responders after renal sympathetic de-nervation (RSD) with radiofrequency technology. Here we report our results repeat RSD using ultrasound in these patients.A cohort study was performed patients who underwent non-response to radiofrequency. Non-response defined as mean daytime systolic blood pressure ≥140 mmHg and/or reduction ≤10 ambulatory measurement (ABPM) ≥6 months denervation. ABPM recorded at baseline, post well three and six...
The risk of femoral stem fracture after total hip replacement is low and can often be associated with a specific implant system or other factors that may reduce the fatigue strength. Additionally, damage to metal component during revision surgery by an electrocautery device further affect behavior.Two clinical cases failure fractured ceramic components are presented; retrieved were analyzed for cause failure. In vitro cyclic load-to-failure testing titanium alloy stems application at 2...