Background Autologous chondrocyte implantation (ACI) is frequently used to treat symptomatic defects of the articular cartilage. Purpose To test whether matrix-associated autologous or original periosteal flap technique provides superior outcomes in terms clinical efficacy and safety. Study Design Randomized controlled trial; Level evidence, 2. Methods Twenty-one patients (mean age, 29.3 ± 9.1 years) with isolated full-thickness cartilage 4.1 09 cm2) at femoral condyle were randomized...

The purpose of this study was to assess the clinical and radiographic long-term outcomes patients treated with a third-generation cemented total shoulder replacement followed for at least ten years.The results thirty-nine arthroplasties were analyzed clinically use Constant score on radiographs in two projections, special regard glenoid component loosening, mean eleven years (range, fifteen years) postoperatively.The 27 points 11 54 points) preoperatively 61 21 86 postoperatively (p <...

Abstract Introduction CD4 + CD25 +/high CD127 low/- regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance. Data about the frequency of Tregs rheumatoid arthritis (RA) are contradictory and based on analysis blood (PB) synovial fluid (SF). Because exert their anti-inflammatory activity contact-dependent manner, membrane (SM) is crucial. Published reports regarding this matter lacking, so we investigated distribution phenotype concurrent samples SM, SF PB RA...

In this prospective randomized clinical trial, the results of epidural corticosteroid injections were evaluated in patients with lumbosciatic pain caused by herniated nucleus pulposus. Thirty-six radicular and positive straight leg raising test because confirmed prolapsed intervertebral lumbar discs into two groups (17 patients) without (19 injection. Members treatment received three 100 mg methylprednisolone 10 mL bupivacaine 0.25% each. Additional therapy was standardized identical both...

We have investigated the mid-term outcome of total shoulder replacement using a keeled cemented glenoid component and modern cementing technique with regard to causes failure loosening components. Between 1997 2003 we performed 96 replacements on 88 patients, 24 men 64 women mean age 69.7 years (31 82). The minimum follow-up was five at time review 87 shoulders (77 patients) were examined 89.1 months (60 127). Cumulative survival curves generated re-operations (accomplished planned),...

It is still controversial which cell types are responsible for synovial inflammation in osteoarthritic (OA) joints. The aim of this study was to quantify the mononuclear populations and their cytokines patients with different knee OA subtypes. Synovial membrane (SM), fluid (SF) peripheral blood (PB) were harvested from unicompartmental (UC) bicompartmental (BC) OA. Frequencies cells assessed by flow cytometry PB SM. Naive SF samples analysed a broad variety multiplex analysis. SM both groups...

The treatment of fracture sequelae the proximal part humerus in combination with posttraumatic arthritis is challenging. reported results anatomic shoulder arthroplasty are disappointing. aim this multicenter study was to analyze clinical and radiographic reverse for malunion tuberosities.This a retrospective, 42 patients (42 shoulders) diagnosis malunions tuberosities who were treated between 2000 2010. mean age at time 68 years (range, 27 83 years; median, 70 years). dominant side 24...

Studies evaluating the return to sports and work after shoulder arthroplasty are rare, there no studies total (TSA).Patients undergoing TSA will be able their preoperative levels occupations.Case series; Level of evidence, 4.A 154 patients with 170 TSAs for primary glenohumeral arthritis were included. Two subgroups formed: who had participated in during 5 years before surgery (group 1; n = 105 [68%]) never 2; 49 [32%]). The return-to-work rate not retired also analyzed, as responses a...

Parameters of MR imaging play a pivotal role in diagnosing lumbar spinal stenosis (LSS), and serve as an important tool clinical decision-making. Despite the importance imaging, little is known about correlation between MRI parameters, objective gait analysis, presentation patients with stenosis.Sixty-three from our clinic symptomatic leading to neurogenic claudication were included this study accordance clearly defined inclusion exclusion criteria. Clinical depression status (CES-D),...

Promising medium-term results from total shoulder arthroplasty (TSA) have been reported for the treatment of primary osteoarthritis in young and middle-aged patients. The aim this study was to evaluate long-term functional radiological outcome TSA patient. data all patients previous were available. At a mean follow-up 13 years (8 17), we reviewed 21 (12 men, nine women, shoulders) with age 55 (37 60). Constant-Murley score (CS) its subgroups subjective satisfaction measured. Radiological...

Conventional stemmed anatomical shoulder prostheses are widely used in the treatment of glenohumeral osteoarthritis. The stemless prosthesis, contrast, is a new concept, and fewer outcome studies available. Therefore, purpose study was to investigate early functional postoperative proprioception prosthesis comparison with standard anatomic prosthesis. Twelve patients (mean age 68.3 years [SD ± 5.4]; 5 female, 7 male) primary osteoarthritis were enrolled, who underwent total arthroplasty...

Thorough understanding of the complex pathophysiology osteoarthritis (OA) is necessary in order to open new avenues for treatment. The aim this study was characterize CD4+ T cell population and evaluate their activation polarization status OA joints. Fifty-five patients with end-stage knee (Kellgren-Lawrence grades III-IV) who underwent surgery total arthroplasty (TKA) were enrolled into study. Matched samples synovial membrane (SM), fluid (SF) peripheral blood (PB) analysed CD3+ CD8-...

Background: Matrix-associated autologous chondrocyte implantation (MACI) is a further development of the original periosteal flap technique (ACI-P) for treatment articular cartilage defects. Purpose: We aimed to establish whether MACI or ACI-P provides superior long-term outcomes in terms patient satisfaction, clinical assessment, and magnetic resonance imaging (MRI) evaluation. Study Design: Randomized controlled trial; Level evidence, 2. Methods: A total 21 patients with defects at femoral...

The purposes of this study were to evaluate the outcome calcaneal lengthening in severe pediatric flexible flatfoot deformities spastic origin and determine necessity additional procedures.In a prospective study, 32 patients (46 feet) evaluated clinically radiologically. mean age was 11 (range 4 22) years. period followup 66 36 108) months.Additional soft-tissue procedures (Strayer procedure, peroneus lengthening, reefing medial capsule) performed 39 46 feet; other bony eight. Among feet,...

Background: Muscle degeneration as a consequence of rotator cuff tears is mainly assessed by magnetic resonance imaging. Contrast-enhanced ultrasound (CEUS) new functional imaging method to assess microvascular perfusion fundamental parameter muscle tissue vitality. In this cross-sectional study, the authors evaluated supraspinatus after repair and analyzed its association with shoulder outcome grade echogenicity in B-mode indicating fatty infiltration. Hypothesis: The expected reduced...

Abstract Background The arthroscopic method offers a less invasive technique of Bankart repair for traumatic anterior shoulder instability. aim the study is to determine mid−/long-term functional outcome, failure rates and predictors after primary Methods A total 100 patients were primarily operated using Medical records retrospectively reviewed, assessed postal questionnaire mean follow-up 8.3 years [3–14]. Clinical assessment was performed Constant score, Rowe American Shoulder Elbow...

In Brief Twenty-five patients in whom the medial head of gastrocnemius muscle was transposed to cover defects limb-sparing surgery malignant bone tumors proximal tibia were evaluated prospectively a tumor register. Surgical technique and mid-term clinical–functional results after mean follow-up 4 years 6 months are presented this study. Twenty-four 25 flaps survived without complications. 1 patient, infection necrosis developed 10 days surgery, requiring revisional transposition. The total...