A5086339870- Reproductive System and Pregnancy
- Pancreatic and Hepatic Oncology Research
- Endometriosis Research and Treatment
- Phagocytosis and Immune Regulation
- Estrogen and related hormone effects
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Endometrial and Cervical Cancer Treatments
- Cancer Mechanisms and Therapy
- CRISPR and Genetic Engineering
- Biotin and Related Studies
- Protein Degradation and Inhibitors
- Neuroblastoma Research and Treatments
- Bone Tumor Diagnosis and Treatments
- Nuclear Structure and Function
- Sarcoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- RNA Research and Splicing
Feinstein Institute for Medical Research
2023-2024
Northwell Health
2023-2024
Cold Spring Harbor Laboratory
2021-2024
Centre for Genomic Regulation
2024
University of California, San Diego
2024
University of Ljubljana
2021
Patients with endometriosis suffer chronic pelvic pain and infertility, from the lack of pharmacologic therapies that consistently halt disease progression. Differences in endometrium patients vs. unaffected controls are well-documented. Specifically, shed endometrial tissues (delivered to cavity via retrograde menstruation) reveal a subset stromal cells exhibiting pro-inflammatory, pro-fibrotic, pro-senescence-like phenotypes is enhanced compared controls. Additionally, cultured...
SRSF1 is the founding member of SR protein family. It required—interchangeably with other proteins—for pre-mRNA splicing in vitro, and it regulates various alternative events. Dysregulation expression contributes to cancer pathologies. Here, we characterized SRSF1’s interactome using proximity labeling mass spectrometry. This approach yielded 190 proteins enriched samples, independently N- or C-terminal location biotin-labeling domain. The detected reflect established functions reveal...
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to resistance that patients develop against chemotherapeutic agents over course treatment. In context non-small cell cancers (NSCLC) harboring EGFR-oncogenic mutations, augmented levels AXL GAS6 have been found drive EGFR tyrosine kinase inhibitors such as Erlotinib Osimertinib certain tumors with mesenchymal-like features. By studying...
Gene fusions with translocations involving nuclear receptor coactivators (NCoAs) are relatively common among fusion‑driven malignancies. NCoAs essential mediators of environmental cues and can modulate the transcription downstream target genes upon binding to activated receptors. Therefore, fusion proteins containing become strong oncogenic drivers, affecting cell transcriptional profile. These tumors show a dependency on oncogene; therefore, direct pharmacological targeting protein becomes...
<title>Abstract</title> Background Patients with endometriosis suffer chronic pelvic pain and infertility, from the lack of pharmacologic therapies that consistently halt disease progression. Differences in endometrium patients vs. unaffected controls are well-documented. Specifically, shed endometrial tissues (delivered to cavity via retrograde menstruation) reveal a subset stromal cells exhibiting pro-inflammatory, pro-fibrotic, pro-senescence-like phenotypes is enhanced compared controls....
ABSTRACT Lung cancer remains the leading cause of cancer-related mortality worldwide, despite current advancements in research and therapeutics. Many patients diagnosed with lung will develop resistance to chemotherapeutic agents. In context non-small cell cancers (NSCLC) harboring EGFR oncogenic mutations, augmented levels AXL GAS6 have been found drive Erlotinib certain tumors mesenchymal-like features. By studying ontogeny AXL-positive cells, we identified a novel non-genetic mechanism...
Abstract Quercetin, a flavonoid with senolytic activity, has attracted great interest as therapy for fibrotic diseases such pulmonary fibrosis, disorder attributed to senescent fibroblasts. Interestingly, quercetin shown some benefit in pre-clinical models of endometriosis, an inflammatory condition characterized by endometrial stromal cells and severe cases, intraperitoneal lesions infertility. Quercetin exerts multiple biological activities but the signaling pathways underlying quercetin’s...
The clustered regularly interspaced short palindromic repeat- (CRISPR-) associated protein 9 (CRISPR/Cas9) technology has become a prevalent laboratory tool to introduce accurate and targeted modifications in the genome. Its enormous popularity rapid spread are attributed its easy use accuracy compared predecessors. Yet, constitutive activation of system limited applications. In this paper, we describe new method that allows temporal control CRISPR/Cas9 activity based on conditional...
The clustered regularly interspaced short palindromic repeat- (CRISPR-) associated protein 9 (CRISPR/Cas9) technology has become a prevalent laboratory tool to introduce accurate and targeted modifications in the genome. Its enormous popularity rapid spread are attributed its easy use accuracy compared predecessors. Yet, constitutive activation of system limited applications. In this paper, we describe new method that allows temporal control CRISPR/Cas9 activity based on conditional...