A5018463223- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Ear and Head Tumors
- Soft tissue tumor case studies
- Elbow and Forearm Trauma Treatment
- Total Knee Arthroplasty Outcomes
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Oral and Maxillofacial Pathology
- Vascular Tumors and Angiosarcomas
- Soft tissue tumors and treatment
- Orthopaedic implants and arthroplasty
- Cancer and Skin Lesions
- Orthopedic Infections and Treatments
- Cardiac tumors and thrombi
- Bone fractures and treatments
- Nonmelanoma Skin Cancer Studies
- Bone health and treatments
- Nail Diseases and Treatments
- Knee injuries and reconstruction techniques
- Tumors and Oncological Cases
Memorial Sloan Kettering Cancer Center
2015-2025
Hospital for Special Surgery
2006-2023
Cornell University
2006-2017
Fugro (Norway)
2017
Johns Hopkins University
2015
National University Hospital
2010-2014
Hospital Universitario Virgen del Rocío
2014
Hospital Universitario Miguel Servet
2014
Brigham and Women's Hospital
2014
The Ohio State University
2014
Life expectancy is routinely used as part of the decision-making process in deciding value surgery for treatment bone metastases. We sought to investigate validity frequently indices prognostication survival patients with metastatic disease.The study prospectively assessed 191 who underwent disease. Diagnostic, staging, nutritional, and hematologic parameters cited be related life were evaluated. Preoperatively, surgeon recorded an estimate projected each patient. The time until death was...
Pathologic proximal femur fractures result in substantial morbidity for patients with skeletal metastases. Surgical treatment is widely regarded as effective; however, failure rates associated the most commonly used operative treatments are not well defined.We therefore compared surgical among intramedullary nailing, endoprosthetic reconstruction, and open reduction-internal fixation when applied to impending or displaced pathologic fractures.We retrospectively clinical course of 298 who...
Low-grade myxofibrosarcoma often relentlessly recurs after surgical resection, with an unusual infiltrative growth pattern and sometimes without a discrete tumor nodule at pathologic examination. This study was undertaken to determine show patterns of recurrent low-grade CT MRI.Unlike in most other histologic types soft-tissue sarcoma, is infiltrative; shows tapering, tail-like margin superficial spreading configuration; metastasizes various distant sites, including lungs, pleura, bone,...
Compliant, self-adjusting compression technology is a novel approach for durable prosthetic fixation of the knee. However, long-term survival these constructs unknown.We therefore determined Compress prosthesis (Biomet Inc, Warsaw, IN, USA) at 5 and 10 actuarial years identified failure modes this form fixation.We retrospectively reviewed clinical radiographic records all 82 patients who underwent knee arthroplasty from 1998 to 2008, as well one patient received device elsewhere but was...
Chondrosarcomas are the second most common primary malignant bone tumors. Although histologic grade is important factor predicting clinical outcome of chondrosarcoma, it subject to interobserver variability. Isocitrate dehydrogenase 1 (IDH1) and IDH2 hotspot mutations were recently found be frequently mutated in central chondrosarcomas. However, a few published articles have been controversial regarding association between IDH1/IDH2 mutation status outcomes chondrosarcomas.We performed...
Limb-sparing surgery has become the preferred surgical treatment of malignant bone tumors. The objective this study was to evaluate factors that influence morbidity and outcome prosthetic knee replacement after resection tumors distal femur.Eighty-two patients who had a tumor femur implantation segmental prosthesis (minimum follow-up, 2 years) were retrospectively reviewed.Twenty-nine (35%) underwent 32 revisions, 6 from perioperative wound complications, 13 aseptic loosening, other...
Myxofibrosarcoma (MFS) has a high local failure rate of up to 79%. We conducted retrospective analysis on all patients with the diagnosis myxofibrosarcoma seen between 1990 and 2004 assess whether improved imaging MRI reduced recurrence, increased survival, radiotherapy following resection influenced outcome. Twenty-one were treated for MFS median followup 52 months (range, 18-122). All surgically treated, 19 receiving limb-sparing surgery. grade disease, positive margins, or prereferral...
Bone ingrowth promises more durable biologic fixation of megaprostheses.The relative performance different types is unknown.We compared the two forms biologically fixed femoral components: an intramedullary uncemented press-fit stem (UCS; Group 1, 50 patients) and a Compress1 (CPS; 2, 41 patients).In overall Kaplan-Meier prosthetic survival rates were 85% at 5 71% 10 years.Most failures longterm developments.Aseptic loosening was primary cause failure.Stem diameters less than 13.5 mm...
Myxoinflammatory fibroblastic sarcoma (MIFS) is a low grade soft tissue with predilection for acral sites, being associated high rate of local recurrence but very infrequent distant metastases. Although t(1;10) translocation resulting in TGFBR3-MGEA5 fusion has been reported as recurrent genetic event MIFS, this abnormality seen only subset cases. As no studies to date have investigated the spectrum alternative alterations negative we undertook analysis particular cohort further molecular...
Desmoplastic small cell tumor (DSCT) is a high-grade malignant neoplasm that shows polyphenotypic differentiation. Its almost exclusive involvement of serosal surfaces (particularly peritoneum) has led to the consideration putative "mesothelioblast" as origin. Although an extraserosal case involving brain (presumably arising from dura) been reported, date no primary in bone or soft tissues documented. The authors describe 34-year-old man who presented with 3-year history pain right hand and...
Patients with musculoskeletal tumors can face large bone deficiency, deformity, and nonunion. Distraction osteogenesis via the Ilizarov method may be useful for reconstruction of these deficiencies allowing limb preservation optimizing function.We reviewed 20 patients a range necessitating surgical treatment. The group included 9 females 11 males mean age 22.6 (8-58) years at follow up 81.7 (26-131) months. deficiency was 7.9 (1.2-18.0) cm.The lengthening achieved 7.1 (3.5-18.0) cm over an...
ABSTRACT Purpose Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low‐grade affecting with predilection the acral soft tissues of middle‐aged adults. Clinically, MIFS associated high rate local recurrence but infrequent distant metastases. The diagnosis remains challenging due to their wide histologic spectrum and overlap reactive, benign, malignant lesions. Moreover, significant limitation that molecular confirmation achieved in only subset cases, its broad range genetic alterations...
Few data exist regarding techniques, indications, and outcomes for sentinel lymph node biopsy in pediatric patients with sarcomas carcinomas.A retrospective 10-year review was conducted, Institutional Review Board waiver, of the pathology, lymphoscintigraphy, clinical records all selected to undergo at a major cancer center.Thirty-one biopsies were performed 30 (median age, 12 years; range, 2-21 years). With administration technetium 99m sulfur colloid, nodes identified preoperatively 31...
While low-grade juxtacortical and intramedullary osteogenic sarcomas are histologically indistinguishable, they have been studied as separate entities. We retrospectively reviewed the clinical, radiographic, histologic features treatment of 59 patients treated surgically to compare rate local recurrence, grade progression, survival between sarcoma. Forty-five (76%) were for sarcoma 14 (24%) Local recurrence rates 7% similar both groups studied. The distant metastases was also groups. ....
Background: Patients with cancer who undergo surgery about the hip are at increased risk for development of deep vein thrombosis. We implemented a program chemical and mechanical prophylaxis to prevent this problem. This study was performed assess effectiveness that program. Methods: Eighty-seven consecutive patients an active malignant tumor underwent replacement our institution over two-year period were included in study. All treated intermittent pneumatic compression devices....