A5101857022- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Vascular Tumors and Angiosarcomas
- Tryptophan and brain disorders
- Treatment of Major Depression
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Tumors and Oncological Cases
- RNA modifications and cancer
- Cancer and Skin Lesions
- Receptor Mechanisms and Signaling
- Ovarian cancer diagnosis and treatment
- Orthopedic Infections and Treatments
- Adenosine and Purinergic Signaling
- Cancer, Lipids, and Metabolism
- Ear and Head Tumors
- Eosinophilic Disorders and Syndromes
- Breast Lesions and Carcinomas
- Head and Neck Surgical Oncology
- Alcoholism and Thiamine Deficiency
- Histiocytic Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Ubiquitin and proteasome pathways
Mount Sinai Hospital
2022-2024
University of Toronto
2022-2024
Qingdao Agricultural University
2024
WinnMed
2019-2022
Memorial Sloan Kettering Cancer Center
2020-2022
Mayo Clinic
2019-2022
Sinai Health System
2021
University of Minnesota Rochester
2021
Mayo Clinic in Arizona
2021
Washington University in St. Louis
2015-2020
Diagnosis and classification of oral epithelial dysplasia (OED) is critical to identifying prognosticating patients at risk squamous cell carcinoma (SCC). However, conventional 3-tiered 2-tiered grading systems suffer from poor inter-pathologist agreement, SCC may arise all grades OED. This study evaluated pathologist agreement in OED as p53 wildtype, abnormal, HPV-associated based on recent evidence demonstrating the utility p53/p16 immunohistochemistry (IHC) this setting increased abnormal...
Inflammation is an important biological process which contributes to risk for depression, in part as a result of the production proinflammatory cytokines and alterations glutamatergic neurotransmission. Ketamine has anti-inflammatory properties might contribute its antidepressant effects. This study was designed clarify mechanisms action ketamine active metabolites, (2R,6R;2S,6S)-hydroxynorketamine (HNK), also appear play major role ketamine's rapid An HMC3 human microglial cell line used...
Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes interindividual variability drug response. The functional characterization unknown significance within ORFs remains a major challenge for pharmacogenomics. Deep mutational scanning (DMS) is high-throughput technique that makes it possible to analyze effect hundreds parallel and scalable fashion. We adapted "landing pad" DMS system study function missense cytochrome P450 family 2 subfamily C...
Abstract The mammalian Vestigial‐like (VGLL) transcriptional cofactor family of proteins VGLL1‐4 has recently emerged as an important player in the tumorigenesis diverse neoplasms. role VGLL3 soft tissue tumors is exemplified by its amplification myxoinflammatory fibroblastic sarcoma and rearrangement (fused to CHD7, CHD9 , or MAMLD1 ) hybrid schwannoma‐perineurioma. This study characterizes a distinctive low‐grade myogenic neoplasm with striking predilection for head neck, characterized...
SATB2 is a sensitive marker for colorectal adenocarcinomas. No study has investigated its diagnostic utility in metastatic Krukenberg tumors (MKTs) of the ovary. Here we performed immunohistochemical staining 70 MKTs various origins (stomach 27, colorectum 13, appendix 20 including 19 adenocarcinomas ex goblet cell carcinoids [AdexGCC] and 1 conventional poorly differentiated carcinoma with signet ring cells, breast 5, bladder 3, lung 2) to assess utility. We also compared CDX2, CK7, CK20,...
Distinguishing low-grade phyllodes tumor from fibroadenoma is practically challenging due to their overlapping histologic features. However, the final interpretation essential surgeons, who base management on pathology report. Patients receive a diagnosis of might not undergo any additional intervention while lumpectomy with wide margins standard care for tumor, which can have significant cosmetic consequences. We studied clinical, immunophenotypic, and proteomics profiles 31 histologically...
We previously reported that SNPs near TSPAN5 were associated with plasma serotonin (5-HT) concentrations which themselves selective reuptake inhibitor treatment outcomes in patients major depressive disorder (MDD). also alcohol consumption and use (AUD) risk. The present study was designed to explore the biological function of a focus on 5-HT kynurenine tryptophan pathway. Ethanol resulted decreased human induced pluripotent stem cell (iPSC)-derived neuron culture media, downregulation gene...
SLCO1B1 (solute carrier organic anion transporter family member 1B1) is an important transmembrane hepatic uptake transporter. Genetic variants in the gene have been associated with altered protein folding, resulting degradation and decreased activity. Next-generation sequencing (NGS) of pharmacogenes being applied increasingly to associate variation drug response genetic sequence variants. However, it difficult link unknown significance functional phenotypes using "one-at-a-time" systems....
Background and Purpose Acamprosate is an anti‐craving drug used for the pharmacotherapy of alcohol use disorder (AUD). However, only some patients achieve optimal therapeutic outcomes. This study was designed to explore differences in metabolomic profiles between who maintained sobriety those relapsed, determine whether provide insight into variation acamprosate treatment response phenotypes. Experimental Approach We previously conducted trial involving 442 AUD patients, 267 these subjects...
Breast adenoid cystic carcinomas (AdCCs) can pose diagnostic difficulty due to their rarity, particularly on limited biopsy material. Given that these tumors are triple-negative breast cancers with favorable prognosis, accurate diagnosis is critical for clinical management. A total of 12 cases AdCCs were studied; 17 age-matched salivary gland and 5 metastatic (1 4 primaries) also examined. Immunohistochemical stains SOX10, Ki-67, c-KIT, β-catenin, epithelial membrane antigen (EMA), p63,...
The definition of papillary thyroid carcinoma, solid variant (PTC-SV) varies from >50% to 100% solid/trabecular/insular growth (STI). We aimed identify prognostic factors and establish an appropriate STI cutoff for PTC-SV in this multi-institutional study 156 PTCs with STI.Nodal metastases were seen 18% associated a higher percentage STI. When substratified by infiltration/encapsulation status, the did not impact risk nodal metastasis. pN1 stage was 51% infiltrative tumours 1% encapsulated...
Special AT-rich sequence-binding protein 2 (SATB2) is a novel marker for colorectal adenocarcinomas but little known about its expression in appendiceal adenocarcinomas. We aim to investigate SATB2 these tumors and with comparison CDX2.Immunohistochemical stains CDX2 were performed 49 (23 conventional, 26 adenocarcinoma ex goblet cell carcinoids (AdexGCCs)) 57 Their was correlated tumor differentiation growth patterns.SATB2 staining positive 26/26 (100%) AdexGCCs 15/23 (65%) conventional (P...
Foxtail millet is a drought-tolerant cereal and forage crop. The basic leucine zipper (
We previously reported that testis‐specific Y‐encoded‐like protein (TSPYLs) are transcription regulators for CYP3A4, CYP2C9, and CYP2C19. Here, we observed dual roles TSPYLs in mediating serotonin transport the metabolism of selective reuptake inhibitors (SSRIs) patients with major depressive disorder (MDD). The widely prescribed SSRIs, citalopram, escitalopram metabolized mainly by TSPYL1 rs3828743 single nucleotide polymorphism (SNP), which decreases its suppression CYP2C19 expression, was...
We recently reported that the P2Y2 receptor (P2Y2R) is predominant nucleotide expressed in human coronary artery endothelial cells (HCAEC) and P2Y2R activation by ATP or UTP induces dramatic up-regulation of tissue factor (TF), a key initiator coagulation cascade. However, molecular mechanism this P2Y2R-TF axis remains unclear. Here, we report role newly identified AP-1 consensus sequence TF gene promoter its original binding components regulation transcription. Using bioinformatics tools,...
Abstract Background Green foxtail [ Setaria viridis (L.)] is one of the most abundant and troublesome annual grass weeds in alfalfa fields Northeast China. Synthetic auxin herbicide widely used agriculture, while how affects tillering on perennial still unclear. A greenhouse experiment was conducted to examine effects 2,4-D green growth, especially tillers. Results In study, isooctyl ester used. There an inhibition plant height fresh weight after application. The photosynthetic rate leaves...
Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase ( TERT ) and short telomeres. Interstitial lung diseases have become the leading indication for transplantation USA, recent data indicate that pathogenic may cause unfavourable outcomes following transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) very poor survival. This case report describes detection of...