A5010920715- Chromatin Remodeling and Cancer
- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Renin-Angiotensin System Studies
- Nuclear Receptors and Signaling
- BRCA gene mutations in cancer
- Neurofibromatosis and Schwannoma Cases
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Hormonal Regulation and Hypertension
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
- RNA modifications and cancer
- Amino Acid Enzymes and Metabolism
- FOXO transcription factor regulation
- Lung Cancer Treatments and Mutations
- Pituitary Gland Disorders and Treatments
- Ferroptosis and cancer prognosis
- Electrolyte and hormonal disorders
- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Cancer Immunotherapy and Biomarkers
- Clusterin in disease pathology
Memorial Sloan Kettering Cancer Center
2019-2025
Kettering University
2024-2025
University of Duisburg-Essen
2013-2021
West Cancer Center
2018
Essen University Hospital
2013-2016
Universitätsmedizin Greifswald
2013
Medical University of Vienna
2011-2012
Anaplastic thyroid carcinoma (ATC) is an orphan disease and confers a dismal prognosis. Standard treatment not established.The aim of this study to describe clinical characteristics, current regimens outcome ATC identify prognostic markers factors associated with improved prognosis.Retrospective cohort at five German tertiary care centers.Totally 100 patients diagnosed between 2000 2015 were included in the analysis. Disease-specific overall survival (OS) was compared Kaplan-Meier method...
Abstract Mutations of subunits the SWI/SNF chromatin remodeling complexes occur commonly in cancers different lineages, including advanced thyroid cancers. Here we show that thyroid-specific loss Arid1a, Arid2, or Smarcb1 mouse BRAFV600E-mutant tumors promotes disease progression and decreased survival, associated with lesion-specific effects on accessibility differentiation. As compared normal thyrocytes, papillary have lineage transcription factor expression to their target DNA binding...
RBM10 modulates transcriptome-wide cassette exon splicing. Loss-of-function mutations are enriched in thyroid cancers with distant metastases. Analysis of transcriptomes and genes mis-spliced by loss showed pro-migratory RHO/RAC signaling signatures. increases cell velocity. Cytoskeletal ECM transcripts subject to inclusion events included vinculin (VCL), tenascin C (TNC), CD44. Knockdown the VCL transcript RBM10-null cells reduced velocity, whereas knockdown TNC CD44 isoforms invasiveness....
// Vera Tiedje 1, * , Saskia Ting 2, Thomas Herold 3 Sarah Synoracki 2 Soeren Latteyer 1 Lars C. Moeller Denise Zwanziger Martin Stuschke 4 Dagmar Fuehrer and Kurt Werner Schmid Department of Endocrinology Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, Duisburg-Essen, Germany Institute Pathology, Consortium (DKTK), Research (DKFZ), Heidelberg, Radiotherapy, These authors contributed equally to this work Correspondence to: Tiedje, email:...
Abstract Cancer cells present neoantigens dominantly through MHC class I (MHCI) to drive tumor rejection cytotoxic CD8+ T-cells. There is growing recognition that a subset of tumors express II (MHCII), causing antigens by TCRs CD4+ T-cells contribute the anti-tumor response. We find mouse Braf V600E -driven anaplastic thyroid cancers (ATC) respond markedly RAF + MEK inhibitors dabrafenib and trametinib (dab/tram) this associated with upregulation MhcII in cancer increased T-cell...
Summary Venous thromboembolism (VTE) is a life-threatening complication in cancer patients. Identification of risk factors has been focus the past years. Functional single nucleotide polymorphisms (SNP) coagulation known to influence concentration or function may be considered VTE We evaluated fibrinogen plasma levels, –455G>A SNP beta gene and Val34Leu (163G>T) factor XIII A-subunit (FXIII-A) on VTE. In 1,079 tumour patients recruited for prospective Vienna Cancer Thrombosis Study...
Objective Thyroid hormone (TH) transporters are expressed in thyrocytes and most play a role TH release. We asked whether expression of the monocarboxylate transporter 8 (MCT8) L-type amino acid LAT2 LAT4 is changed with thyrocyte dedifferentiation hyperfunctioning thyroid tissues. Design methods Protein localization was determined by immunohistochemistry human specimen including normal tissue (NT, n = 19), follicular adenoma (FA, 44), carcinoma (FTC, 45), papillary (PTC, 40), anaplastic...
Medullary thyroid carcinoma (MTC) occurs sporadically in 75% of patients. Metastatic disease is associated with significantly poorer survival. The aim this study was to identify prognostic markers for progressive MTC and oncogenic factors response vandetanib therapy.Clinical courses 32 patients sporadic (n=10 pN0cM0, n=8 pN1cM0, n=14 pN1cM1) were compared genetic profiles the patients' primary tumour tissue. Analysis RET proto-oncogene mutations performed by Sanger sequencing next-generation...
Abstract Anaplastic thyroid cancer (ATC) is a clinically aggressive malignancy with dismal prognosis. Combined BRAF/MEK inhibition offers significant therapeutic benefit in patients BRAF V600E -mutant ATCs. However, relapses are common and overall survival remains poor. Compared differentiated cancer, hallmark of ATCs infiltration myeloid cells, particularly macrophages. most the aging population, which also has an increased incidence TET2 clonal hematopoiesis (CH). CH-mutant macrophages...
Thyroid nodules are a common endocrine condition with an increasing incidence over the decades. Data-independent acquisition has been widely utilized in discovery proteomics to identify disease biomarkers and therapeutic targets. To analyze thyroid disease-related proteome high-throughput, reproducible reliable manner, we introduce thyroid-specific peptide spectral libraries. Here, generated four deep-coverage libraries through mass spectrometers comprising Q Exactive HF, Orbitrap Exploris...
The tyrosine kinase inhibitors (TKI) vandetanib and cabozantinib are approved as targeted therapies in advanced medullary thyroid carcinoma (MTC) with symptoms or high tumour burden. Only recently, toxicity long-time TKI usage was analysed. However, little is known about the impact of discontinuation on MTC disease course after longer-term therapy. Here, we report our experience a series 7 patients treatment up to 87 months followed by for concerns due side-effects. therapy relevant clinical...
Die Konzepte zur Molekularpathogenese von Schilddrüsentumoren haben sich in den letzten Jahren kontinuierlich weiterentwickelt. Als entscheidender Faktor wurde Schilddrüsenkarzinomen die konstitutive Aktivierung intrazellulärer Tyrosinkinasen identifiziert. In Follikelzell-basierten Karzinomen scheint MAPK- und PI3K-Signalkaskaden über somatische Mutationen Gen-Rearrangements eine entscheidende Rolle zu spielen. niedrig differenzierten anaplastischen wird oftmals Akkumulation genetischer...
Multiple sclerosis (MS) is a complex neurodegenerative disease presenting with diversity of clinical symptoms including palsy and cognitive impairment. We present 59-year-old woman history secondary progressive MS since 1987, who was referred to our department because recent onset confusion polydipsia. Initial lab tests showed mildly elevated serum sodium levels low urine osmolality. Under water deprivation, diuresis osmolality persisted rose above 150 mmol/l. Oral desmopressin resulted in...
Abstract Most BC patients succumb to metastatic relapse years decades following primary tumor resection due reactivation of dormant disseminated cancer cells (DCCs). Improved patient survival has led manifesting in an older population. This population carries somatic mosaicism many organs including bone marrow. Age-specific mutations (e.g., DNMT3A, ASXL1, TET2) hematopoietic stem and progenitor (HSPCs) results CH, which is associated with increased inflammatory myeloid risk leukemia...
ABSTRACT RBM10 modulates transcriptome-wide cassette exon splicing. Loss-of-function mutations are enriched in thyroid cancers with distant metastases. Analysis of transcriptomes and genes mis-spliced by loss showed pro-migratory RHO/RAC signaling signatures. increases cell velocity. Cytoskeletal ECM transcripts subject to exon-inclusion events included vinculin (VCL), tenascin C (TNC) CD44. Knockdown the VCL inclusion transcript -null cells reduced velocity, whereas knockdown TNC CD44...
Medullary thyroid cancer (MTC) occurs sporadically in 75% of all cases. In patients with local disease prognosis is excellent. metastatic 10-year survival significantly decreased. For the therapy progressive MTC two tyrosine kinase inhibitors, vandetanib and cabozantinib, are currently available.