A5008419611- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Thyroid and Parathyroid Surgery
- Pituitary Gland Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Thyroid Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- Viral Infections and Outbreaks Research
- Immunotherapy and Immune Responses
- Salivary Gland Tumors Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Animal Virus Infections Studies
- Cardiac Structural Anomalies and Repair
- interferon and immune responses
- Hormonal Regulation and Hypertension
- Protease and Inhibitor Mechanisms
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
Essen University Hospital
2020-2025
University of Duisburg-Essen
2017-2024
Deutschen Konsortium für Translationale Krebsforschung
2021-2024
European Neuroendocrine Tumor Society
2023
With this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent severe AN eight-month duration was treated off-label metreleptin. Hyperactivity assessed accelerometry. Visual analogue scales (VAS), validated self- clinician rating lab results tracked changes from baseline to...
Early genetic association studies yielded too high risk estimates for multiple endocrine neoplasia (MEN2A), suggesting a need extended surgery.The objective was to delineate temporal changes in MEN2A presentation by birth cohort analyses.Birth analyses (10-year increments; ≤1950 2011-2020) of carriers rearranged during transfection (RET) mutations who underwent surgery MEN2A.Included this study were 604 (155 index, 445 nonindex, 4 additional patients), with 237 harboring high-risk mutations,...
(1) Background: The wider adoption of a preoperative ultrasound and calcitonin screening complemented by an intraoperative frozen section has increased the number patients with occult sporadic medullary thyroid cancer (MTC). These advances offer new opportunities to reduce extent initial operations, minimizing operative morbidity risk postoperative thyroxin supplementation without compromising cure. (2) Methods: This systematic review international literature published in English language...
The age-specific development of the three constituent components multiple endocrine neoplasia type 2 (MEN 2) is incompletely characterized for many >30 causative rearranged during transfection ( RET ) mutations, which this genetic association study aimed to specify. Included in were 683 carriers heterogeneous germline mutations: 53 with 1 highest-risk mutation (codon 918); 240 8 different high-risk mutations 634); 176 16 intermediate-risk 609, 611, 618, 620, or 630); and 214 6 low-risk...
Ziel/Aim: Sofern beim differenzierten Schilddrüsenkarzinom (DTC) im Anschluss an die Operation eine Radioiodtherapie (RIT) indiziert ist, erfolgt dies entweder unter endogener TSH-Stimulation Absetzen der Schilddrüsenhormon-Medikation (THW) oder exogen durch rhTSH-Injektion. Die prätherapeutische 124I-Dosimetrie wird seit 2003 am UK-Essen zur Optimierung RIT eingesetzt. Das Ziel dieser retrospektiven Arbeit war es, mögliche Unterschiede in den Dosimetriedaten (Energiedosen, Uptake,...
Background: Anaplastic thyroid cancer (ATC) is the most aggressive with a median survival of about 6 months. So far, no therapies offering benefit are established. Thus, new therapeutic approaches urgently needed. In general, genetic alterations leading to ATC increase PI3K and MAPK/ERK signalling include mutations in receptor tyrosine kinases tumour suppressor genes. They often occur together loss P53, prevalent mutation human ATC. Among such rearrangements anaplastic lymphoma kinase (ALK)...
To identify the attitudes of German thyroid specialists towards clinical treatment hypothyroidism using hormones (TH).All members section Endocrine Society (DGE) were e-mailed an invitation to participate in a web-based survey about substitution with TH.Out 206 DGE's section, 163 (79.1%) responses received and included analysis. Of responding members, 98.6% used levothyroxine (LT4) as choice, 45.4% also prescribed combination therapy liothyronine (LT4+LT3) their practice (p<0.001). LT4+LT3...
Abstract Immune-mediated effector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironment restricts antitumour immunity. New therapeutic approaches that induce a strong and prolonged would represent major immunotherapeutic advance. Here we show arenaviruses lymphocytic choriomeningitis virus (LCMV) clinically used Junin vaccine (Candid#1) preferentially replicate cells variety murine human models. Viral replication leads to local activation,...
Immune activation within the tumor is one promising approach to induce immune-mediated regression. Certain viruses including oncolytic like herpes simplex virus (HSV) and non-oncolytic such as lymphocytic choriomeningitis (LCMV) are potent tools tumor-specific immune activation, however not all types respond viro- and/or immunotherapy mechanisms explaining differences remain be defined. We used non-cytopathic LCMV in different human melanoma models found that cell lines produced high levels...
Background: The clinical phenotype of poorly differentiated thyroid cancer (PDTC) can vary substantially. We aim to evaluate risk factors for radioiodine refractory (RAI-R) disease and reduced overall survival (OS). Methods: retrospectively screened our institutional database PDTC patients. For the assessment RAI-R disease, we included patients who underwent dual imaging with 18F-FDG-PET 124I-PET/131I scintigraphy that met internal standard care. tested primary size, extrathyroidal extension...
Schilddrüsenkarzinome sind die häufigsten endokrinen Malignome. Ihre molekulare Pathogenese ist gut untersucht und hat für Therapie fortgeschrittener Stadien große Bedeutung. Differenzierte, gering differenzierte anaplastische Karzinome haben ihren Ursprung in der Follikelepithelzelle Schilddrüse, während medulläre von den C‑Zellen Schilddrüse ausgehen. In meisten Fällen Prognose des differenzierten Schilddrüsenkarzinoms nach Operation Radiojodtherapie sehr günstig. Verlieren Tumoren...
Medullary thyroid carcinomas (MTC) are rare and aggressive neuroendocrine tumors of the thyroid. About 70% MTC sporadic; approximately 50% those harbor somatic RET mutation. DLL3 is widely expressed in many has been evaluated as a potential therapeutic target. Since stromal desmoplasia sporadic identified reliable predictor behavior development lymph node metastases, possible correlation expression with presence was particular interest. 59 paraffin-embedded samples (44 cases) without (15...
In contrast to all prior AJCC/TNM classifications for differentiated thyroid cancer (DTC) the 8th edition does not take minimal extrathyroidal extension (M-ETE) into consideration local tumor staging. We therefore aimed retrospectively assess specific impact of M-ETE on outcome patients treated in our clinic.DTC with and a follow-up time ≥ 5 years were included matched an identical number without M-ETE, but equal histopathological subtype size. The frequency initially metastatic disease...
The tyrosine kinase inhibitors (TKI) vandetanib and cabozantinib are approved as targeted therapies in advanced medullary thyroid carcinoma (MTC) with symptoms or high tumour burden. Only recently, toxicity long-time TKI usage was analysed. However, little is known about the impact of discontinuation on MTC disease course after longer-term therapy. Here, we report our experience a series 7 patients treatment up to 87 months followed by for concerns due side-effects. therapy relevant clinical...
The onset of radioiodine-refractory thyroid carcinoma (RR-TC) is a negative predictor survival and has been linked to the presence BRAF<sup>V600E</sup> mutations in papillary cancer. We aimed identify further genetic alterations associated with RR-TC. <b>Methods:</b> included 38 patients cancer who underwent radioiodine imaging <sup>18</sup>F-FDG PET/CT after total thyroidectomy. molecular profile was assessed by next-generation sequencing. time RR-TC for different compared using log-rank...
<b><i>Introduction:</i></b> Primary squamous cell carcinoma (PSCC) of the thyroid is an exceptionally rare malignancy accounting for &#x3c;1% all primary cancers. Therapy multimodal including surgery, radiotherapy, and chemotherapy but with no consensus management therapy. Here, we describe a case male patient who presented BRAF V600E-mutated PSCC gland showing response to combined dabrafenib trametinib therapy over period &#x3e;12 months....
Das medulläre Schilddrüsenkarzinom ("medullary thyroid cancer" [MTC]) ist ein Paradebeispiel für Präzisionsmedizin in der Endokrinologie und verdeutlicht den unmittelbaren Nutzen von Grundlagen-, translationaler Versorgungsforschung Patienten mit einer seltenen Erkrankung im klinischen Alltag. Eine Mutation Rearranged-during-transfection(RET)-Protoonkogen, das eine transmembranäre Rezeptortyrosinkinase codiert, führt zur konstitutiven Aktivierung Kinase; dies entscheidende Pathomechanismus...
Zusammenfassung Radiojodrefraktäre differenzierte Schilddrüsenkarzinome Die Wirksamkeit der Multikinase-Inhibitoren Lenvatinib und Sorafenib kann anhand von „Real-world“-Anwendungsdaten verschiedener Krebszentren weltweit gezeigt werden. Zur Behandlung des fortgeschrittenen rrDTC (radioiodine-refractory differentiated thyroid cancer) steht Cabozantinib als Zweitlinienpräparat nach Progress unter und/oder zur Verfügung. Bislang zeigte sich weiter eine geringe Wahrscheinlichkeit, dass...