Sukumar Namineni
A5048748990- interferon and immune responses
- Immune Response and Inflammation
- Virus-based gene therapy research
- Helicobacter pylori-related gastroenterology studies
- Glaucoma and retinal disorders
- Immune Cell Function and Interaction
- Cerebral Venous Sinus Thrombosis
- Cancer therapeutics and mechanisms
- Viral Infections and Outbreaks Research
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Tuberculosis Research and Epidemiology
- Chemical Reactions and Isotopes
- Hepatitis C virus research
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Cancer Treatment and Pharmacology
- S100 Proteins and Annexins
- Salivary Gland Tumors Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Pituitary Gland Disorders and Treatments
- Salmonella and Campylobacter epidemiology
Ludwig-Maximilians-Universität München
2022-2024
German Cancer Research Center
2017-2020
Heidelberg University
2017-2020
Technical University of Munich
2014-2020
Helmholtz Zentrum München
2012-2020
DKFZ-ZMBH Alliance
2020
Indian Institute of Science Bangalore
1999-2010
Innate immune activation is essential to mount an effective antiviral response and prime adaptive immunity. Although a crucial role of CD169+ cells during vesicular stomatitis virus (VSV) infections increasingly recognized, factors regulating viral remain unclear. Here, we show that tumor necrosis factor produced by CD11b+ Ly6C+ Ly6G+ following infection with VSV. The absence TNF or receptor 1 (TNFR1) resulted in reduced numbers type I interferon (IFN-I) production VSV infection, severe...
The detection of microbes and damaged host cells by the innate immune system is essential for defense against infection tissue homeostasis. However, how distinct positive negative regulatory signals from receptors are integrated to tailor specific responses in complex scenarios remains largely undefined. Clec12A a myeloid cell-expressed inhibitory C-type lectin receptor that can sense cell death under sterile conditions. detects uric acid crystals limits proinflammatory pathways...
Abstract Immune-mediated effector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironment restricts antitumour immunity. New therapeutic approaches that induce a strong and prolonged would represent major immunotherapeutic advance. Here we show arenaviruses lymphocytic choriomeningitis virus (LCMV) clinically used Junin vaccine (Candid#1) preferentially replicate cells variety murine human models. Viral replication leads to local activation,...
Helicobacter pylori colonizes half of the global population and causes gastritis, peptic ulcer disease or gastric cancer. In this study, we were interested in human annexin (ANX), which comprises a protein family with diverse partly unknown physiological functions, but potential role microbial infections possible involvement We demonstrate here for first time that H . is able to specifically bind ANXs. Binding studies purified LPS specific mutant strains indicated binding ANXA5 lipid A, was...
•LCMV infection activates NF-κB signaling in hepatocytes.•Macrophages, TNFR1 do not induce LCMV-driven hepatocyte NF-κB-activation.•IkkβΔHep mice display increased viral infection/replication and lower ISG induction.•IfnarΔHep recapitulate aberrant virus replication as observed IkkβΔHep mice.•NF-κB is required for efficient induction HBV-/HDV-infected HepaRG. Background & AimsHepatic innate immune control of infections has largely been attributed to Kupffer cells, the liver-resident...
Helicobacter pylori (H. pylori) is a bacterial pathogen that exclusively colonizes the human gastric mucosa and can cause persistent infection. In this process, H. employs various strategies to avoid recognition by immune system. These range from passive defense (e.g., altered LPS or flagellin structures) prevent pattern receptors (PRRs) more active approaches, such as inhibition of IL-2 secretion proliferation T cells via VacA. Despite growing evidence actively manipulates system for its...
Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver macrophages. However, also hepatocytes, parenchymal cells liver, possess potent immunological functions in addition their known metabolic functions. Owing abundance and functions, we aimed investigate direct anti-viral mechanisms employed by hepatocytes.