A5027960489- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
- interferon and immune responses
- Metabolism and Genetic Disorders
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Systemic Sclerosis and Related Diseases
- Peripheral Artery Disease Management
- Fetal and Pediatric Neurological Disorders
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
Université de Sherbrooke
2021-2023
University of Liège
2020-2021
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2021
Université Toulouse III - Paul Sabatier
2015-2016
Centre National de la Recherche Scientifique
2015-2016
Inserm
2015-2016
Centre de Physiopathologie de Toulouse-Purpan
2015-2016
Congenital infection by human cytomegalovirus (HCMV) is a leading cause of permanent sequelae the central nervous system, including sensorineural deafness, cerebral palsies or devastating neurodevelopmental abnormalities (0.1% all births). To gain insight on impact HCMV neuronal development, we used both neural stem cells from embryonic (NSC) and brain sections infected fetuses investigated outcomes Peroxisome Proliferator-Activated Receptor gamma (PPARγ), transcription factor critical in...
Background and Aims Therapeutic strategies against HBV focus, among others, on the activation of immune system to enable infected host eliminate HBV. Hypoxia‐inducible factor 1 alpha (HIF1α) stabilization has been associated with impaired responses. pathogenesis triggers chronic hepatitis‐related scaring, leading inter alia modulation liver oxygenation transient activation, both factors playing a role in HIF1α stabilization. Approach Results We addressed whether interferes immune‐mediated...
•LCMV infection activates NF-κB signaling in hepatocytes.•Macrophages, TNFR1 do not induce LCMV-driven hepatocyte NF-κB-activation.•IkkβΔHep mice display increased viral infection/replication and lower ISG induction.•IfnarΔHep recapitulate aberrant virus replication as observed IkkβΔHep mice.•NF-κB is required for efficient induction HBV-/HDV-infected HepaRG. Background & AimsHepatic innate immune control of infections has largely been attributed to Kupffer cells, the liver-resident...
Congenital infection by human cytomegalovirus (HCMV) is a leading cause of congenital abnormalities the central nervous system. Placenta HCMV allows for viral spread to fetus and may result in intrauterine growth restriction, preeclampsia-like symptoms, or miscarriages. We previously reported that activates peroxisome proliferator-activated receptor gamma (PPARγ) its own replication cytotrophoblasts. Here, we investigated molecular bases PPARγ activation infected cytotrophoblasts.We show...
Immune-mediated induction of cytidine deaminase APOBEC3B (A3B) expression leads to HBV covalently closed circular DNA (cccDNA) decay. Here, we aimed decipher the signalling pathway(s) and regulatory mechanism(s) involved in A3B related control. Differentiated HepaRG cells (dHepaRG) knocked-down for NF-κB components, transfected with siRNA or micro RNAs (miRNA), primary human hepatocytes ± HBVΔX HBV-RFP, were treated lymphotoxin beta receptor (LTβR)-agonist (BS1). The biological outcomes...
Congenital infection of the central nervous system by human cytomegalovirus (HCMV) is a leading cause permanent sequelae, including mental retardation or neurodevelopmental abnormalities. The most severe complications include smooth brain polymicrogyria, which are both indicative abnormal migration neural cells, although underlying mechanisms remain to be determined. To gain better insight on pathogenesis such we assessed expression levels set neurogenesis-related genes, using HCMV-infected...
Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver macrophages. However, also hepatocytes, parenchymal cells liver, possess potent immunological functions in addition their known metabolic functions. Owing abundance and functions, we aimed investigate direct anti-viral mechanisms employed by hepatocytes.
Abstract Background The esophagus is in constant contact with the austere environment caused by food and gastric reflux. It protected a squamous epithelium which maintenance provided rare subpopulation of basal cells: Keratin 15+ (Krt15+) stem cells. However, little known about mechanisms underlying expansion function these was shown that transcription factor ASCL2 strongly upregulated Krt15+ cells compared to Krt15- Interestingly, gene target Wnt/β-catenin pathway, acts as regulator...
Abstract Background The stratified epithelium of the esophagus includes Krt15+ basal stem cells that display self-renewing and regenerative capacity, multipotency. However, mechanisms specifically control their functions remain unknown. Interestingly, RNA sequencing GSEA revealed an enrichment a gene set associated with DNA repair in vs Krt15- cells. We also observed Msh2 (DNA mismatch pathway) is most significantly upregulated Aims To determine effect loss on self-renewal differentiation...
Abstract Background The esophagus is lined by a stratified epithelium in which basal cells can proliferate and undergo differentiation while migrating towards the lumen. In layer, we also find Krt15+ stem that are multipotent, self-renewing have regenerative capacity. However, mechanisms specifically control their functions remain unknown. Interestingly, RNA sequencing gene set enrichment analysis (GSEA) revealed an of associated with DNA repair comparison to Krt15- cells. We observed Msh2...