A5032952340- Immune Response and Inflammation
- Particle physics theoretical and experimental studies
- Immunotherapy and Immune Responses
- Astrophysics and Cosmic Phenomena
- interferon and immune responses
- Antifungal resistance and susceptibility
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Noncommutative and Quantum Gravity Theories
- Neutrino Physics Research
- RNA modifications and cancer
- Inflammasome and immune disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Acute Ischemic Stroke Management
- Biotin and Related Studies
- IL-33, ST2, and ILC Pathways
- Escherichia coli research studies
- Cerebral Venous Sinus Thrombosis
- Peptidase Inhibition and Analysis
- Tuberculosis Research and Epidemiology
- Cosmology and Gravitation Theories
- Cardiac tumors and thrombi
Cedars-Sinai Medical Center
2020-2024
Tianjin Medical University
2023
Second Hospital of Tianjin Medical University
2023
Institute of High Energy Physics
2022
Chinese Academy of Sciences
2011-2022
Klinikum rechts der Isar
2019
Technical University of Munich
2019
German Center for Infection Research
2019
München Klinik
2016
Xiamen University
2015
The detection of microbes and damaged host cells by the innate immune system is essential for defense against infection tissue homeostasis. However, how distinct positive negative regulatory signals from receptors are integrated to tailor specific responses in complex scenarios remains largely undefined. Clec12A a myeloid cell-expressed inhibitory C-type lectin receptor that can sense cell death under sterile conditions. detects uric acid crystals limits proinflammatory pathways...
The aim of this study was to evaluate the efficacy recombinant adenovirus p53 agent (rAd-p53) injection combined with cisplatin (CDDP) for treatment malignant pleural or peritoneal effusion. After puncture drainage, patients in group (n = 27) received intracavitary administration rAd-p53 (2 x 10(12) virus particles) once a week 4 weeks. At 48 h after each injection, were given 60 mg/m(2). This procedure continued control 21) same therapy as but without therapy. Efficacy evaluated by clinical...
OBJECTIVES: To investigate the possibility of culturing dendritic cells (DCs) and cytokine-induced killer (CIK) cells, obtained at initial diagnosis AML in elderly patients, to safety efficacy treatment with autologous DCs CIK when administered these patients combination low-dose chemo therapy. METHODS: were cultured used therapy treat (immunotherapy group). Elderly treated only chemotherapy served as control. Before on day 7 after T cell subsets cytokine levels evaluated immunotherapy...
Tumor vascular targeting is one of the most promising strategies in tumor therapy. Here we used E.coli to express a recombinant SP5.2/tTF fusion protein, which, as agent, consists SP5.2 (a peptide selectively binding and VEGFR-1 on endothelial cells) truncated tissue factor (tTF)and aimed explore its anti-tumor activities.The expression construct was synthesized by polymerase chain reaction (PCR) recombined into plasmid pET22b(+). The gene verified restriction mapping sequencing. expressed...
Abstract Hypoxia-inducible factor 1α (Hif1α) is a key regulator of cellular adaptation and survival under hypoxic conditions. In pancreatic ductal adenocarcinoma (PDAC), it has been recently shown that genetic ablation Hif1α accelerates tumour development by promoting tumour-supportive inflammation in mice, questioning its role as the downstream target many oncogenic signals PDAC. Likely, context-dependent tumorigenesis. To further analyse this, murine PDAC cell lines with reduced expression...
Dectin-1 recognizes β-glucan in fungal cell walls, and activation of dendritic cells (DCs) influences immune responses against fungi. Although many studies have shown that DCs activated via induce different subsets T helper according to cytokine milieus, the mechanisms underlying such differences remain unknown. By harnessing polymorphic Candida albicans polystyrene beads sizes, we find target size production cytokines control differentiation subsets. Hyphal C. large activate but cannot be...
is an important intestinal parasite that mainly transmitted through the fecal-oral route. Human infection may occur following ingestion of water and food contaminated by