A5059741867- Cancer Genomics and Diagnostics
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Genetic factors in colorectal cancer
- Retinal Development and Disorders
- Ovarian cancer diagnosis and treatment
- Traumatic Brain Injury Research
- Biotin and Related Studies
- Glaucoma and retinal disorders
- SARS-CoV-2 detection and testing
- BRCA gene mutations in cancer
- Williams Syndrome Research
- Retinopathy of Prematurity Studies
- Developmental Biology and Gene Regulation
- Mitochondrial Function and Pathology
- Prenatal Screening and Diagnostics
- Colorectal Cancer Treatments and Studies
- Advanced Proteomics Techniques and Applications
- Biochemical effects in animals
- Pregnancy and preeclampsia studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Respiratory viral infections research
- Biosensors and Analytical Detection
- Retinal Imaging and Analysis
Cedars-Sinai Medical Center
2016-2024
Cedars-Sinai Smidt Heart Institute
2024
Johns Hopkins University
2008-2022
Johns Hopkins Medicine
2014-2022
Cancer Genetics (United States)
2015-2022
Sidney Kimmel Comprehensive Cancer Center
2022
Osaka University
2020
Howard Hughes Medical Institute
2014-2015
Sidney Kimmel Cancer Center
2015
Heidelberg University
2013
Abstract The global scientific response to COVID 19 highlighted the urgent need for increased throughput and capacity in bioanalytical laboratories, especially precise quantification of proteins that pertain health disease. Acoustic ejection mass spectrometry (AEMS) represents a much-needed paradigm shift ultra-fast biomarker screening. Here, quantitative AEMS assays is presented, employing peptide immunocapture enrich (i) 10 acute phase (APR) protein markers from plasma, (ii) SARS-CoV-2...
Pregnancies resulting from fresh in vitro fertilization (IVF) cycles exposed to supraphysiologic estrogen levels have been associated with higher rates of low birth weight and small for gestational age babies. We identified GATA3, a transcription factor selectively expressed the trophectoderm during blastocyst stage embryo development, an upstream analysis genes that were differentially methylated chorionic villus samples between IVF non-IVF infertility treatment pregnancies. In this study,...
SLC1A1, which encodes the neuronal and epithelial glutamate transporter, is a promising candidate gene for obsessive-compulsive disorder (OCD). In this study, we conducted capillary electrophoresis single-strand conformation polymorphism (CE-SSCP) screen all 12 identified exons, including coding regions approximately 50 bp of flanking introns human SLC1A1 in 378 OCD-affected individuals. Full sequencing was completed on samples that showed an aberrant SSCP tracing identification underlying...
Purpose.: To define the role of hypoxia and vascular endothelial growth factor (VEGF) in modifying pattern, density, permeability retinal vasculature mouse models which Norrin/Frizzled4 signaling is impaired. Methods.: Retinal structure was analyzed mice with mutation Ndp (the gene coding for Norrin) or Frizzle4 (Fz4) without three additional perturbations: (1) hyperoxia reduction VEGF, (2) reduced induction VEGF response to hypoxia, (3) responsiveness cells (ECs) VEGF. These perturbations...
Abstract Several clinical and genetic studies have reported gender differences in obsessive–compulsive disorder (OCD). Previously, we conducted a linkage genome scan using multipoint allele‐sharing methods to test for 219 families participating the OCD Collaborative Genetics Study. When these were stratified by proband's gender, suggestive chromosome 11p15 at marker D11S2362 (KAC all = 2.92, P 0.00012) was detected with male probands, but not ones female probands. We since fine mapping...
Abstract Background: Despite evidence that obsessive‐compulsive disorder (OCD) is a familial neuropsychiatric condition, progress aimed at identifying genetic determinants of the has been slow. The OCD Collaborative Genetics Study (OCGS) identified several susceptibility loci through linkage analysis. Methods: In this study we investigate two regions on chromosomes 15q and 1q by first refining region using additional short tandem repeat polymorphic (STRP) markers. We then performed...
A novel strategy for delivering functionalised superparamagnetic iron oxide nanoparticles to the outer surface of pancreatic islet grafts, using chemically modified polymeric nanolayers, has been developed tracking engrafted islets by magnetic resonance imaging.
Rationale The b n −1 ion of a peptide, as well [ + 18] ion, can be observed not only normal product ions, but also prominent metastable ions in reflectron‐embedded matrix‐assisted laser desorption ionization time‐of‐flight spectrometer. m / z values for the peaks are slightly shifted compared with ordinary and appear relatively broad peaks, which permits them to discriminated from other ions. Methods A standard protein mixture gel‐derived proteins digested LysN protease, cleaves peptide...