A5092492358- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Autoimmune and Inflammatory Disorders Research
- Hereditary Neurological Disorders
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- HER2/EGFR in Cancer Research
Hospital for Special Surgery
2023-2025
It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in the synovium; however, recent studies reveal scores patients do not correlate with synovial inflammation. We developed a machine-learning approach (graph-based gene expression module identification or GbGMI) identify an 815-gene associated biopsy samples from established RA who had limited at arthroplasty. then validated this finding independent cohort of early untreated little Single-cell RNA...
Objective Fatigue is important for patients with rheumatoid arthritis (RA) but poorly understood. We sought to study associations of fatigue clinical features, disease activity, and synovial histology. Methods Patients meeting the American College Rheumatology/EULAR 1987 and/or 2010 RA criteria were recruited before elective total joint replacement. Demographics, characteristics, tender swollen joints, erythrocyte sedimentation rate (ESR) C‐reactive protein, patient‐reported fatigue,...
Objective We sought to develop computer vision methods quantify aggregates of cells in synovial tissue and compare these with clinical gene expression parameters. Methods assembled a pipeline five features encompassing cell density compared pathologist scores, disease classification, autoantibody status, RNA cohort 156 patients rheumatoid arthritis (RA) 149 osteoarthritis (OA). Results All were associated scores lymphocytic inflammation ( P < 0.0001). Three that related the per unit...
Abstract It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in the synovium; however, recent studies reveal scores patients do not correlate with synovial inflammation. We identified a module of 815 genes associated pain, using novel machine learning approach, Graph-based Gene expression Module Identification (GbGMI), samples from longstanding RA, but limited at arthroplasty, and validated this finding an independent cohort biopsy early, untreated RA...