Amit Lakhanpal
A5083922662- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Spectroscopy and Quantum Chemical Studies
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Cancer Genomics and Diagnostics
- Apelin-related biomedical research
- Gene expression and cancer classification
- Diffusion and Search Dynamics
- Genomics and Rare Diseases
- Inflammasome and immune disorders
- Statistical Methods in Clinical Trials
- interferon and immune responses
- Dermatological and COVID-19 studies
- Biosimilars and Bioanalytical Methods
- CAR-T cell therapy research
- Chronic Kidney Disease and Diabetes
- Genetic Associations and Epidemiology
Hospital for Special Surgery
2020-2025
Cornell University
2020-2025
Weill Cornell Medicine
2022-2025
Center for Rheumatology
2020-2023
University of California, Los Angeles
2007
To report the clinical experience with anakinra in preventing mechanical ventilation patients coronavirus disease 2019 (COVID-19), symptoms of cytokine storm syndrome, and acute hypoxemic respiratory failure.To be included this retrospective case series, must have had severe syndrome 2 (SARS-CoV-2), fever, ferritin levels >1,000 ng/ml 1 additional laboratory marker hyperinflammation, failure. Acute failure was defined as requiring 15 liters supplemental oxygen via a nonrebreather mask...
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA repertoire sequencing on paired synovial tissue blood samples from 12 seropositive RA patients. We identify clonally expanded CD4 + cells, including CCL5+ cells peripheral helper (Tph) which show a prominent transcriptomic signature of recent activation effector function. CD8 higher oligoclonality than with the largest clones enriched in GZMK+ possibly...
Abstract Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation these yet to be defined. Here, we examine genome-wide open chromatin at single-cell resolution 30 samples, including 12 samples with transcriptional data multimodal experiments. We identify 24 classes and predict their associated transcription factors,...
Summary Rheumatoid arthritis (RA) is a prototypical autoimmune disease that causes destructive tissue inflammation in joints and elsewhere. Clinical challenges RA include the empirical selection of drugs to treat patients, inadequate responders with incomplete remission, lack cure. We profiled full spectrum cells inflamed synovium from patients goal deconstructing cell states pathways characterizing pathogenic heterogeneity RA. Our multicenter consortium effort used multi-modal CITE-seq,...
Delayed detection of LN associates with worse outcomes. There are conflicting recommendations regarding a threshold level proteinuria at which biopsy will likely yield actionable management. This study addressed the association urine protein:creatinine ratios (UPCR) clinical characteristics and investigated incidence proliferative membranous histology in patients UPCR between 0.5 1.A total 275 SLE (113 first biopsy, 162 repeat) were enrolled multicentre multi-ethnic/racial Accelerating...
Fibroblasts play critical roles in tissue homeostasis, but pathologic states they can drive fibrosis, inflammation, and destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform RNA sequencing identify a gene expression program healthy synovial fibroblasts characterized by enhanced fatty acid metabolism lipid transport. We cortisol as key driver fibroblast phenotype that depletion adipocytes, which express high levels Hsd11b1, results loss...
We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced complement-mediated vascular injury thrombosis, consistent prior reports. Serial aPL testing demonstrated high levels anticardiolipin (aCL) that declined to insignificant over period 5 weeks. RNA was detected in nasopharyngeal swab on serial assays performed the same 5-week...
Immune checkpoint inhibitors (ICI) can potentially cause ICI-inflammatory arthritis (ICI-IA), which often resembles rheumatoid (RA). In this study, we examined the degree of anticitrullinated peptide antibodies (ACPA) epitope expansion in CCP+ICI-IA and patients with RA.
We propose a stochastic process wherein molecular transport is mediated by asymmetric nucleation of domains on one-dimensional substrate, in contrast with motors that hydrolyze nucleotide triphosphates and undergo conformational change. show hydrolysis waves track can also result directed motion an attached particle. Asymmetrically cooperative kinetics between hydrolyzed unhydrolyzed states each lattice site generate moving domain walls push particle sitting the track. use novel...
Abstract In rheumatoid arthritis (RA), macrophages represent key therapeutic targets due to their ability drive inflammation. Interestingly, new subtypes of RA have been identified, based on distinct patterns cell types in the joint, wherein one-third patients demonstrate an enrichment pro-fibrotic SPP1hiCLEC5Ahi macrophages. We set out understand what drives formation these joints, and how anti-inflammatory medications used treat may differentially affect joints with versus pro-inflammatory...