A5000757390- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Synthesis and Biological Evaluation
- Legume Nitrogen Fixing Symbiosis
- Plant chemical constituents analysis
- Antimicrobial Resistance in Staphylococcus
- Advanced Glycation End Products research
- Nematode management and characterization studies
- Enzyme Production and Characterization
- Probiotics and Fermented Foods
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Synthesis of Organic Compounds
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Neonatal and Maternal Infections
- Microbial Fuel Cells and Bioremediation
- Helicobacter pylori-related gastroenterology studies
- Plant-Microbe Interactions and Immunity
Children's Hospital of Philadelphia
2023-2024
University of Pennsylvania
2022-2024
The University of Texas Medical Branch at Galveston
2024
Northeastern University
2019-2020
Abstract In Bacillus subtilis , robust biofilm formation requires large quantities of ferric iron. Here we show that this process preferential production a siderophore precursor, 2,3-dihydroxybenzoate, instead the bacillibactin. A proportion iron is associated extracellularly with matrix. The biofilms are conductive, extracellular potentially acting as electron acceptor. relatively small internalized and boosts iron-containing enzymes involved in respiratory transfer establishing strong...
infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccine targeting
Bacteriocins are peptides or proteins synthesized by bacterial ribosomes that show killing inhibitory activities against different groups of bacteria. considered potential alternatives to traditional antibiotics, preservatives in pharmaceutical and food industries. A strain L-Q11 isolated from orchard soil was phylogenetically characterized as Bacillus subtilis based on 16S rRNA gene sequencing analysis. novel class I bacteriocin (Subtilin L-Q11), identified purified cell-free supernatant a...
Background : Staphylococcus aureus is a leading cause of healthcare-associated infection and one the most common pathogens causing serious invasive in neonatal intensive care unit (NICU). Asymptomatic colonization by S. presents significant risk for subsequent colonized infant patient-to-patient transmission. Transmission more virulent strains NICU could increase this vulnerable population. Methods We performed three-year, unit-wide screening Children's Hospital Philadelphia (CHOP) NICU,...
ABSTRACT Toxin production by Clostridioides difficile damages the colonic epithelium and leads to a robust inflammatory response. This disruption of epithelial barrier markedly alters nutritional landscape in C. difficile- infected gut. The impact toxin-mediated remodeling during infection (CDI) on resident microbiota remains largely unexplored. One group opportunistic pathogens, enterococci, thrive CDI, but it is unclear what strategies they employ survive this altered environment. Here, we...
Environmental strains of the soil bacterium Bacillus subtilis have valuable applications in agriculture, industry, and biotechnology; however, environmental are genetically less accessible. This reduced accessibility is sharp contrast to laboratory strains, which well known for their natural competence, a limitation applications. In this study, we observed that robust biofilm formation by B. greatly frequency competent cells biofilm. By using model strain 3610, revealed cross-pathway...
Vibrio cholerae is the etiologic agent of severe human diarrheal disease cholera. To colonize mammalian hosts, this pathogen must defend against host-derived toxic compounds, such as nitric oxide (NO) and NO-derived reactive nitrogen species (RNS). RNS can covalently add an NO group to a cysteine thiol on target proteins, process called protein S-nitrosylation, which may affect bacterial stress responses. better understand how V . regulates nitrosative responses, we profiled S-nitrosylation...
Abstract Environmental strains of the soil bacterium Bacillus subtilis have valuable applications in agriculture, industry, and biotechnology. They are capable forming robust biofilms demonstrate excellent biological control activities plant protection. However, environmental genetically less accessible, a sharp contrast to laboratory well known for their natural competence limitation toward application. In this study, we observed that biofilm formation greatly reduces rate competent cells...