A5070909204- Vibrio bacteria research studies
- Escherichia coli research studies
- Child Nutrition and Water Access
- Gut microbiota and health
- Microbial Metabolism and Applications
- Enzyme Production and Characterization
- Aquatic Ecosystems and Biodiversity
- Advanced Glycation End Products research
- Aquaculture disease management and microbiota
University of Pennsylvania
2018-2022
SignificanceIn a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword shield of commensal microbes in competition with invading pathogens each other. The identification an
Vibrio cholerae, the aetiological agent of cholera, possesses multiple iron acquisition systems, including those for transport siderophores. How these systems benefit V. cholerae in low-iron, polymicrobial communities environmental settings or during infection remains poorly understood. Here, we demonstrate that iron-limiting conditions, co-culture with a number individual siderophore-producing microbes significantly promoted growth vitro . We further show host environment low iron,...
Vibrio cholerae is the etiologic agent of severe human diarrheal disease cholera. To colonize mammalian hosts, this pathogen must defend against host-derived toxic compounds, such as nitric oxide (NO) and NO-derived reactive nitrogen species (RNS). RNS can covalently add an NO group to a cysteine thiol on target proteins, process called protein S-nitrosylation, which may affect bacterial stress responses. better understand how V . regulates nitrosative responses, we profiled S-nitrosylation...
Purpose. The gastrointestinal tract is home to thousands of commensal bacterial species. Therefore, competition for nutrients paramount successful pathogen invasion intestinal ecosystems. human Vibrio cholerae, the causative agent severe diarrhoeal disease, cholera, able colonize small intestine, which protected by mucus. However, it unclear metabolic pathways or V. cholerae utilizes during colonization and growth. Methodology. In this study, we investigated effect various key genes,...