A5061412853- Immune cells in cancer
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Respiratory viral infections research
- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
- Advanced Numerical Methods in Computational Mathematics
- interferon and immune responses
- Autophagy in Disease and Therapy
- COVID-19 diagnosis using AI
- Cancer Immunotherapy and Biomarkers
- Insect Utilization and Effects
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- Numerical methods in engineering
- Ferroptosis and cancer prognosis
Carter Center
2023-2024
University of Virginia
2022-2024
Capital Medical University
2024
University of Minnesota
2024
Mayo Clinic in Arizona
2020-2023
Central South University of Forestry and Technology
2023
Central South University
2023
Mayo Clinic
2019-2023
Ruian People's Hospital
2020-2023
First Affiliated Hospital of Anhui Medical University
2023
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the circulation; however, it is currently unknown whether elicits effective immune responses respiratory tract, particularly against variants of concern (VOCs), including Omicron. We compared S-specific total neutralizing antibody responses, B T cell immunity, bronchoalveolar lavage fluid (BAL) blood COVID-19-vaccinated individuals hospitalized patients. Vaccinated had significantly lower levels D614G, Delta...
Identification of a CD4 + helper T cell population providing in situ help to B and CD8 cells the respiratory mucosa.
Respiratory tissue resident–like CD8 + T cells are associated with chronic lung sequelae post-acute COVID-19.
Lower respiratory viral infections, such as influenza virus and severe acute syndrome coronavirus 2 often cause pneumonia in aged individuals. Here, we report that leads to chronic nonresolving lung pathology exacerbated accumulation of CD8+ tissue-resident memory T cells (TRM) the tract hosts. TRM cell relies on elevated TGF-β present tissues. Further, show isolated from lungs lack a subpopulation characterized by expression molecules involved TCR signaling effector function. Consequently,...
The relationship between diabetes and coronavirus disease 2019 (COVID-19) is bidirectional: Although individuals with high blood glucose (hyperglycemia) are predisposed to severe COVID-19, acute respiratory syndrome 2 (SARS-CoV-2) infection can also cause hyperglycemia exacerbate underlying metabolic syndrome. Therefore, interventions capable of breaking the network SARS-CoV-2 infection, hyperglycemia, hyperinflammation, all factors that drive COVID-19 pathophysiology, urgently needed. Here,...
Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) represent an urgent public health challenge and are estimated to affect more than 60 million individuals globally. Although a growing body evidence suggests that dysregulated immune reactions may be linked with PASC symptoms, most investigations have primarily centered around blood-based studies, few focusing on samples derived from affected tissues. Furthermore, clinical studies alone often...
Cepharanthine (CEP) is a potential candidate for treatment of cerebral ischemia/reperfusion (I/R) injury, due to its anti-inflammatory and anti-oxidative properties. To investigate the effect CEP on I/R we established mouse model transient middle artery occlusion (tMCAO) microglia cell oxygen glucose deprivation/reoxygenation (OGD/R). Administration attenuated neurological deficits, reduced infarct volume edema, decreased activation in MCAO mice. Immunofluorescence staining showed an...
Abstract Influenza virus infection causes increased morbidity and mortality in the elderly. Aging impairs immune response to influenza, both intrinsically because of altered interactions with endothelial pulmonary epithelial cells. To characterize these changes, we performed single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, bulk (bulk RNA-seq) on lung tissue from young aged female mice at days 0, 3, 9 post-influenza infection. Our analyses identified dozens key genes...
Alveolar macrophages (AMs) are major lung tissue-resident capable of proliferating and self-renewal in situ. AMs vital pulmonary antimicrobial immunity surfactant clearance. The mechanisms regulating AM compartment formation maintenance remain to be fully elucidated currently. In this study, we have explored the roles mitochondrial transcription factor A (TFAM)-mediated fitness metabolism function. We found that TFAM deficiency mice resulted significantly reduced numbers impaired maturation...
Abstract Severe infection commonly results in immunosuppression, which leads to impaired pathogen clearance or increased secondary both humans and animals. However, the exact mechanisms remain poorly understood. Here, we demonstrate that IL-33 immunosuppression by inducing thymic involution-associated naive T cell dysfunction with aberrant expression of aging-associated genes impairs host control mouse disease models schistosomiasis sepsis. Furthermore, illustrate triggers excessive...
Cancer-associated fibroblasts (CAFs) play a role in ovarian cancer (OV) evolution, immunosuppression and promotion of drug resistance. Exploring the value CAFs-related biomarker OV is great importance. In present work, we developed index (CAFRI) based on an integrated analysis single-cell bulk RNA-sequencing highlighted CAFRI predicting clinical outcomes individuals with OV, tumour immune microenvironment (TIME) response to checkpoint inhibitors (ICIs). The GSE151214 cohort was used for cell...
Abstract Background We evaluated prevaccine pandemic period COVID-19 death risk factors among nursing home (NH) residents. Methods In a retrospective cohort study covering Medicare fee-for-service beneficiaries aged ≥65 years residing in US NHs, we estimated adjusted hazard ratios (HRs) using multivariate Cox proportional hazards regressions. Results Among 608251 elderly NH residents, 57398 (9.4%) died of COVID-19–related illness 1 April to 22 December 2020; 46.9% (26893) these deaths...
Alveolar macrophages (AMs) are resident innate immune cells that play vital roles in maintaining lung physiological functions. However, the effects of aging on their dynamics, heterogeneity, and transcriptional profiles remain to be fully elucidated. Through single cell RNA sequencing (scRNA-seq), we identified CBFβ as an indispensable transcription factor ensures AM self-renewal. Intriguingly, despite transcriptome similarities proliferating cells, AMs from aged mice exhibited reduced...
Mussels are a kind of economically valuable ocean bivalve shellfish. It has short harvest period and is susceptible to contamination during storage processing. Having proper preservation methods critical prevent quality deterioration. However, the effect low voltage variable frequency electric field compound preservative on freshness steamed mussels in ice-temperature still unknown. We utilized method coefficient variation weighting calculate overall scores stored under different conditions....
The development of CAR-T-cell immunotherapy has notably elevated the efficacy treating multiple myeloma. Currently, a variety targets, including BCMA, CS1, CD38, FcRH5, and GPRC5D, are being investigated. Despite these significant advancements, challenges such as antigen escape, limited persistence CAR-T cells, intricate nature tumor microenvironment persist, leading to relapses following treatment.