A5102976564- Advanced Glycation End Products research
- Neuroscience and Neuropharmacology Research
- Human Pose and Action Recognition
- Antiplatelet Therapy and Cardiovascular Diseases
- Corneal Surgery and Treatments
- Parasites and Host Interactions
- Vestibular and auditory disorders
- Retinal Diseases and Treatments
- Text and Document Classification Technologies
- Nutrition, Genetics, and Disease
- Acute Myocardial Infarction Research
- Vacuum and Plasma Arcs
- Nuclear Receptors and Signaling
- Landslides and related hazards
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Eosinophilic Esophagitis
- Emotion and Mood Recognition
- Lymphatic System and Diseases
- Hearing, Cochlea, Tinnitus, Genetics
- Chemokine receptors and signaling
- Retinal Imaging and Analysis
- Immune Cell Function and Interaction
- Statistical Methods in Clinical Trials
- Global Public Health Policies and Epidemiology
- Bone Metabolism and Diseases
Nanjing Medical University
2020-2025
Shaoxing University
2025
Guangzhou Medical University
2024
Guangzhou Women and Children Medical Center
2024
Shanghai Tongji Urban Planning and Design Institute
2023
Tongji University
2023
Shenyang Anorectal Hospital
2023
Yanbian University
2010-2022
Zhengzhou University
2022
The University of Tokyo
2011-2022
Abstract Severe infection commonly results in immunosuppression, which leads to impaired pathogen clearance or increased secondary both humans and animals. However, the exact mechanisms remain poorly understood. Here, we demonstrate that IL-33 immunosuppression by inducing thymic involution-associated naive T cell dysfunction with aberrant expression of aging-associated genes impairs host control mouse disease models schistosomiasis sepsis. Furthermore, illustrate triggers excessive...
Abstract Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality life. High-salt diet (HSD) has long been closely associated with occurrence development depression, but whether or how HSD causes remains unclear. In this study, induces depression-like behavior in mice accompanied by an increase IL-17A production. RORγt deficiency abolishes HSD-induced mice. Furthermore, γδT17 cells are...
Vitamin D status is closely related to blood glucose and bone metabolism in patients with type 2 diabetes (T2DM). affects density metabolism, leading osteopenia osteoporosis. Insulin resistance increases the risk of osteoporosis T2DM. Our previous studies have shown a negative correlation between insulin 25-hydroxy vitamin [25(OH)D] levels. The aim present study was determine association T2DM.A retrospective cross-section research carried out among 109 non-osteoporosis Their fasting (FBG),...
<b><i>Aims:</i></b> Oxidative damage plays a vital role in the pathogenesis of age-related macular degeneration (AMD). Exendin-4 (EX4), glucagon-like peptide-1 receptor agonist, possesses several pharmacological functions, such as anti-inflammatory and antioxidative properties. However, effects mechanism EX4 on oxidative stress retinal pigment epithelial (RPE) cells induced by hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) remain unclear. The...
Infection with schistosome results in immunological changes that might influence the skeletal system by inducing states affecting bone metabolism. We investigated relationships between chronic infection and metabolism using a mouse model of schistosomiasis, millions humans worldwide. Results showed resulted aberrant osteoclast-mediated loss, which was accompanied an increased level receptor activator nuclear factor-κB (NF-κB) Ligand (RANKL) decreased osteoprotegerin (OPG). The blockade RANKL...
The present study investigated the clinical significance of mannose-binding lectin 2 (MBL2), cluster differentiation 14 (CD14) and tumour necrosis factor-α (TNF-α) gene polymorphisms in patients with spinal tuberculosis (TB) Chinese population.A total 240 TB were enrolled from May 2013 to August 2016 at Hangzhou Red Cross Hospital. A 150 age- sex-matched healthy subjects as controls. genomic DNA was extracted peripheral blood all subjects, MBL2, CD14 TNF-α detected by direct sequencing.(1)...
Schistosomiasis is a serious and neglected disease with high prevalence in tropical subtropical countries. The primary pathology of hepatic schistosomiasis caused by Schistosoma japonicum (S. japonicum) or mansoni mansoni) infection egg-induced granuloma subsequent fibrosis the liver. Activation stellate cells (HSCs) central driver liver fibrosis. Macrophages (Mφ), making up 30% granulomas, directly indirectly regulate HSC activation paracrine mechanisms, via secreting cytokines chemokines....
Purpose The aim of this study is to apply deep learning techniques for the development and validation a system that categorizes various phases dry age-related macular degeneration (AMD), including nascent geographic atrophy (nGA), through analysis optical coherence tomography (OCT) images. Methods A total 3,401 OCT images obtained from 338 patients admitted Shenyang Aier Eye Hospital in 2019–2021 were collected classification model. We adopted convolutional neural network (CNN) model...
In spoken dialog systems, it is important to reduce the delay in generating a response user's utterance. We investigate use of incremental recognition results which can be obtained from speech engine before input utterance ends. To enable system respond correctly end utterance, desired utilize effectively, although they are not reliable enough. formulate this problem as decision making task, makes choices iteratively either answer based on previous observations, or wait until next...
Long-term synaptic plasticity in the cerebellar cortex is a possible mechanism for motor learning. Previous studies have demonstrated induction of mossy fiber-granule cell (MF-GrC) under vitro and vivo conditions, but mechanisms underlying sensory stimulation-evoked long-term MF-GrC living animals are unclear. In this study, we investigated potentiation (LTP) transmission cerebellum induced by train facial stimulation at 20 Hz urethane-anesthetized mice using electrophysiological recording,...
In this study, we evaluated the impact of preoperative high mobility group box 1 (HMGB1) on myocardial injury post-percutaneous coronary intervention. We 302 consecutive patients who underwent percutaneous They were divided into equal tertiles based their HMGB1 levels. Creatine kinase-MB and troponin I levels measured at baseline, 8- 24-hours after procedure, while clinical outcomes followed up for year. The occurrence post-procedural was significantly higher in tertile comprising with...
Evaluating the accuracy (ie, estimating sensitivity and specificity) of new diagnostic tests without presence a gold standard is practical meaning has been subject intensive study for several decades. Existing methods use 2 or more under basic assumptions then estimate parameters via maximum likelihood estimation. One conditional independence given disease status. This assumption impractical in many real applications veterinary research. Several have proposed with various dependence models...
Chemokine receptor CXCR5-mediated control of B cell trafficking in the lymphoid tissues plays a central role orchestrating function, which not only guides colocalization cells with follicular helper T mantle zone but also determines position germinal center dark and light zones. However, mechanisms that regulate expression CXCR5 remain unclear. Here, we show level was substantially reduced vitro culture conditions, while being maintained presence CD40 signals. Furthermore, signaling promotes...
With the development of human-computer interaction, gesture recognition is becoming more and important. At same time, mobile applications are developing rapidly, it a trend to implement interaction technology on terminal. An improved YOLOv4-tiny algorithm proposed. Firstly, basis network, Spatial Pyramid Pooling(SPP) module added integrate local global features image enhance accurate positioning ability network. Secondly, 1×1 convolution after 3 maximum pooling layers original network newly...
Objective: To explore the effect of Balint group on emotional labor and job burnout nurses in cardiology, to provide a reference for improving mental health cardiology. Methods: A total 78 pediatric were randomly divided into observation control by random number table, 39 received general nursing training intervention 8- week group, not anything intervention. Before after 8 weeks, The Emotional Labor Scale(ELS) Maslach Burnout Inventory(MBI) used evaluate nurses. Results: age was(26.3±2.7)...
<title>Abstract</title> The primary cause of branchio-oto-renal syndrome (BORS) is mutations in the EYA1 gene. This study aimed to explore impact and underlying mechanisms on podocyte injury. We collected clinical genetic data from a 4-year-old girl diagnosed with BORS her family. Induced pluripotent stem cells (iPSC) were derived peripheral blood mononuclear both patient healthy individuals, which differentiated into podocytes vitro. RNA-seq was used analyze differentially expressed genes...
The surge protective device (SPD), as buildings over-voltage device, has been widely used in building’s power distribution system. A novel SPD based on hollow cathode effects is designed. In both air and nitrogen gas, the relationship of discharging voltage gas pressure are measured, critical ranges determined condition U p pulse protection level). results indicate that, gap distance D=3 mm small hole diameter φ=3 mm, operating from 50 to 5×10 4 Pa. With D increasing, level decreasing...