A5082362795- Luminescence and Fluorescent Materials
- Catalytic Cross-Coupling Reactions
- Molecular Sensors and Ion Detection
- Synthetic Organic Chemistry Methods
- Organic Light-Emitting Diodes Research
- Catalytic C–H Functionalization Methods
- Organic Electronics and Photovoltaics
- Catalytic Alkyne Reactions
- Nanoplatforms for cancer theranostics
- Asymmetric Synthesis and Catalysis
- Conducting polymers and applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cyclopropane Reaction Mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Photochromic and Fluorescence Chemistry
- Organic Chemistry Cycloaddition Reactions
- Traditional and Medicinal Uses of Annonaceae
- Organoboron and organosilicon chemistry
- Oxidative Organic Chemistry Reactions
- Supramolecular Self-Assembly in Materials
- Synthesis and pharmacology of benzodiazepine derivatives
- Chemical Synthesis and Analysis
Institute of Chemistry, Academia Sinica
2002-2018
Academia Sinica
1992-2018
Institute of Chemistry
2011-2017
Michigan Technological University
2005-2010
Sichuan University
2003
Purdue University West Lafayette
1982-1986
Stanford University
1985
National Tsing Hua University
1982-1983
A series of novel highly water-soluble neutral BODIPY dyes have been obtained by functionalization with branched oligo(ethylene glycol)methyl ether groups at positions 8, 2 and 6 or 4 4′. Use an ortho-substituent group on the meso-phenyl ring replacement fluorine atoms 4′ methyloxy ethynyl subunits significantly enhance fluorescence quantum yields dyes.
Four near-infrared fluorescent probes (A, B, C and D) have been synthesized, characterized, evaluated for detection of lysosomal pH inside living cells. The display highly sensitive selective response to acidic as the results in drastic structural changes from spirocyclic (non-fluorescent) forms ring-opening (fluorescent) probes. fluorescence intensities (B, increase significantly by more than 200-fold 7.4 4.2. probe D bearing N-(2-hydroxyethyl) ethylene amide residue possesses advantages...
Three BODIPY-based near-infrared fluorescent probes have been synthesized, characterized, and evaluated for the sensing imaging of lysosomal pH inside living cells.
The Pd-catalyzed cross-coupling reaction of e i t h r m a y l z n c derivatives w unsaturated organic halides o org reagents g Zn A1 can produce cleanly and regiospec f the correspondingcarbo-substitutedhetemaromatic conpounds'in high d s .h cmss-coupling orgimic presence Ni 2 3 Pd catalysts has as v useful synthetic complemnt Cubased ~d .~
Three uncommon morpholine-based fluorescent probes (
A zinc(II) chelator bis(pyridin-2-ylmethyl)amine moiety has been incorporated into three different highly water-soluble dyes, 2-formyl-BODIPY, 2,6-diformyl BODIPY, and 2,6-diformyl-1,7-distyryl-BODIPY, at 2-position 2,6-positions, resulting in BODIPY-based fluorescent probes A, B C for ions. Fluorescent display sensitive responses with significant fluorescence enhancement to ions pH 7.0 while probe shows two distinct measurable signals 521 nm 661 nm, displays ratiometric quenching nm. These...
Abstract Mapping surface hydrophobic interactions in proteins is key to understanding molecular recognition, biological functions and central many protein misfolding diseases. Herein, we report synthesis application of new BODIPY-based sensors (HPsensors) that are stable highly fluorescent for pH values ranging from 7.0 9.0. Surface measurements (BSA, apomyoglobin myoglobin) by these HPsensors display much stronger signal compared 8-anilino-1-naphthalene sulfonic acid (ANS), a commonly used...
A novel fluorescent cassette consisting of a TPE donor and cyanine acceptor was developed for sensitive detection pH changes in live cells.
Five fluorescent probes bearing coumarin moieties with spirolactam ring structures have been developed to detect pH changes in visible and near-infrared channels.
We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide an effective three-nitrogen-atom one-oxygen-atom binding motif. large Stokes shifts offer sensitive selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring concentration changes in living cells, detecting intracellular released...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective carbon-carbon bond formation via transition-metal catalysis. 33. Palladium-catalyzed cross-coupling reaction of .alpha.-heterosubstituted alkenylmetals. A stereoselective route to heterosubstituted dienes suitable for the Diels-Alder reactionEiichi Negishi and Fentair LuoCite this: J. Org. Chem. 1983, 48, 9, 1560–1562Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1...
Three BODIPY-based ratiometric fluorescent probes (1, 2 and 3), with two being highly soluble in aqueous solution, were prepared by the condensation of 2-formyl-BODIPY dyes 2,3,3-trimethyl-1-propyl-3H-indolium iodide 2,3,3-trimethyl-1-(3-sulfonatepropyl)-3H-indolium for selective sensitive responses to cyanide ions.
Two water-soluble near-infrared luminescent probes, which possess both conventional intense Stokes fluorescence and unique single-photon frequency upconversion luminescence (FUCL), were developed for sensitive selective detection of pH changes in live cells. The water solubility biocompatibility these probes achieved by introducing mannose residues through 2,2'-(ethylenedioxy)diethylamine tethered spacers to a (CF) FUCL organic fluorophore. At higher than 7.4, the have ring-closed...
Formyl groups at 6- and 2,6-positions initiated Knoevenagel reactions of the methyl 7, 1,7-positions 1,3,5,7-tetramethyl BODIPY dyes with aromatic aldehydes. Formation vinyl bonds 7-, facilitates further 3,5-positions. This approach offers fast, facile versatile ways to prepare potential novel building blocks for conjugated oligomers, dendrimers, highly water-soluble, near-infrared emissive sensing materials.
Two near-infrared luminescent probes with Stokes-shift and single-photon anti-Stokes-shift fluorescence properties for sensitive determination of pH variance in lysosomes have been synthesized. A morpholine residue probe which serves as a targeting group viable cells was attached to the fluorophores via spirolactam moiety while mannose ligated B resulting increased biocompatibility solubility water. Probes contain closed moieties, show no or under neutral alkali conditions. However,...
Three highly water-soluble near-infrared emissive polymeric BODIPY dyes (polymers A–C) were prepared by the palladium-catalyzed Suzuki polymerization of 2,6-diiodo-3,5-distyryl-BODIPY with 1,4-phenyldiboronic acid and 2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9,9-di[1-[2-(2-methoxyethoxy)ethoxy]ethyl]fluorene, respectively. Partial replacement fluorine subunits cores at 4,4-positions polymer C ethynyl resulted in a dye (polymer D). Polymers A–D show solubility least 20 mg mL−1...
One-pot Knoevenagel self-condensation reaction of β-formyl BODIPY dye bearing a formyl group at 2-position offered dimeric, trimeric and tetrameric dyes containing capping end group, exhibiting panchromatic absorption.
A 2,6-diformyl-BODIPY dye has been modified by transforming its formyl groups at the 2,6-positions into different functional such as hydroxyl, carboxylic acid, cyano, nitro and oxime groups, resulting in a series of new BODIPY dyes. The optical properties dyes significantly depend on 2,6-positions.