A5015769149- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Genomics and Chromatin Dynamics
- Porphyrin and Phthalocyanine Chemistry
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Steroid Chemistry and Biochemistry
- RNA modifications and cancer
- Chemical Synthesis and Analysis
- Estrogen and related hormone effects
- Lipid Membrane Structure and Behavior
- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Photochemistry and Electron Transfer Studies
- Pharmaceutical Practices and Patient Outcomes
- Patient Safety and Medication Errors
- Cancer-related gene regulation
- Amyotrophic Lateral Sclerosis Research
The University of Texas Health Science Center at San Antonio
2022-2024
University of Michigan
2020-2023
Purbanchal University
2021
Michigan Technological University
2016-2020
Houghton University
2017
Five fluorescent probes bearing coumarin moieties with spirolactam ring structures have been developed to detect pH changes in visible and near-infrared channels.
We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide an effective three-nitrogen-atom one-oxygen-atom binding motif. large Stokes shifts offer sensitive selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring concentration changes in living cells, detecting intracellular released...
Two near-infrared luminescent probes with Stokes-shift and single-photon anti-Stokes-shift fluorescence properties for sensitive determination of pH variance in lysosomes have been synthesized. A morpholine residue probe which serves as a targeting group viable cells was attached to the fluorophores via spirolactam moiety while mannose ligated B resulting increased biocompatibility solubility water. Probes contain closed moieties, show no or under neutral alkali conditions. However,...
The residue lysine 28 (K28) is known to form an important salt bridge that stabilizes the Aβ amyloid structure, and acetylation of (K28Ac) slows Aβ42 fibrillization rate but does not affect fibril morphology. On other hand, 16 (K16Ac) greatly diminishes property peptide also affects its toxicity. This due fact acetylated beta forms amorphous aggregates instead fibrils. likely a result increased hydrophobicity K16-A21 region K16 acetylation, as confirmed by molecular dynamic simulation...
Family B2 or adhesion G protein-coupled receptors (AGPCRs) are distinguished by variable extracellular regions that contain a modular protease, termed the GPCR autoproteolysis-inducing domain self-cleaves receptor into an N-terminal fragment (NTF) and C-terminal (CTF), seven transmembrane (7TM). The NTF CTF remain bound after cleavage through noncovalent interactions. binding to ligand(s) presented nearby cells, matrix anchors NTF, such cell movement generates force induce NTF/CTF...
SUMMARY Alternative splicing is a fundamental process that contributes to the functional diversity and complexity of proteins. The regulation each alternative event involves coordinated action multiple RNA-binding proteins, creating diverse array alternatively spliced products. Dysregulation associated with various diseases, including neurodegeneration. Here we demonstrate CELF2, regulator GWAS-identified risk factor for Alzheimer’s disease, binds mRNAs neurodegenerative specific interaction...
<b>Abstract ID 17396</b> <b>Poster Board 478</b> The second largest group of G protein coupled receptors (GPCRs) is the class B2 or adhesion GPCRs (AGPCRs). AGPCRs are distinguished by variable extracellular regions that contain a membrane-proximal GPCR autoproteolysis-inducing (GAIN) domain self cleaves to generate two receptor fragments, N-terminal fragment (NTF) and C-terminal (CTF), seven transmembrane (7TM). fragments remain non-covalently bound after self-cleavage. We hypothesize...
Summary Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that Androgen Receptor (AR), a steroid hormone-regulated transcription factor, forms condensates through multivalent interactions androgen orchestrate assembly. We demonstrate the intrinsically disordered N-terminal domain (NTD) AR drives 1,6-Hexanediol-sensitive condensate formation...