A5012926126- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- CRISPR and Genetic Engineering
- Chronic Myeloid Leukemia Treatments
- RNA Research and Splicing
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Cancer, Lipids, and Metabolism
- T-cell and B-cell Immunology
- Caveolin-1 and cellular processes
- Metabolism, Diabetes, and Cancer
Shandong First Medical University
2023-2024
Affiliated Hospital of Taishan Medical University
2023-2024
California Institute of Technology
2022-2023
<div>Abstract<p>Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with wide range of biological functions. In 30% acute myeloid leukemia (AML), the terminal exon <i>NPM1</i> often found mutated, resulting in addition nuclear export signal and shift to cytoplasm (NPM1c). AMLs carrying this mutation have aberrant expression <i>HOXA/B</i> genes, whose overexpression leads leukemogenic transformation. Here, for first time, we comprehensively...
<div>Abstract<p>Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with wide range of biological functions. In 30% acute myeloid leukemia (AML), the terminal exon <i>NPM1</i> often found mutated, resulting in addition nuclear export signal and shift to cytoplasm (NPM1c). AMLs carrying this mutation have aberrant expression <i>HOXA/B</i> genes, whose overexpression leads leukemogenic transformation. Here, for first time, we comprehensively...
<p>Supplementary Figure S1 is associated with Figure1 and it shows the NPM1-WT binds to rDNA arrays NPM1c non-repetitive genomic regions. Supplementary S2 NPM1c’s chromatin binding association gene expression. S3 Figure2 regulates transcription of its target genes BRU-seq. S4 characterization condensate biochemical assay imaging assay. S5 figure 3. The landacpe dymanics during dTag-13 treatment wash-off. S6 4. It supplemental data HOXB8-NPM1c-knock-in model. S7 5. XPO1's in various...
<p>Supplementary Figure S1 is associated with Figure1 and it shows the NPM1-WT binds to rDNA arrays NPM1c non-repetitive genomic regions. Supplementary S2 NPM1c’s chromatin binding association gene expression. S3 Figure2 regulates transcription of its target genes BRU-seq. S4 characterization condensate biochemical assay imaging assay. S5 figure 3. The landacpe dymanics during dTag-13 treatment wash-off. S6 4. It supplemental data HOXB8-NPM1c-knock-in model. S7 5. XPO1's in various...
Summary Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that Androgen Receptor (AR), a steroid hormone-regulated transcription factor, forms condensates through multivalent interactions androgen orchestrate assembly. We demonstrate the intrinsically disordered N-terminal domain (NTD) AR drives 1,6-Hexanediol-sensitive condensate formation...
Abstract Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with wide range of functions including ribosome biogenesis, mRNA processing, and maintenance genomic stability. In acute myeloid leukemia (AML), the terminal exon NPM1 often mutated (~30% adult AMLs), changing localization signal into nuclear export signal, which results in shift to cytoplasm (NPM1c). AMLs carrying this mutation have an aberrant expression HOXA genes, whose overexpression leads leukemogenic...