A5030038799- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Neurological disorders and treatments
- Gastroesophageal reflux and treatments
- HIV/AIDS Research and Interventions
- Quality and Safety in Healthcare
- Aortic Disease and Treatment Approaches
- Pluripotent Stem Cells Research
- Parkinson's Disease Mechanisms and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Syphilis Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Health Systems, Economic Evaluations, Quality of Life
- Patient Safety and Medication Errors
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Radiopharmaceutical Chemistry and Applications
- Liver physiology and pathology
Leiden University Medical Center
2017-2024
Leiden University
2023
Community Hospital
2001
University Hospital Frankfurt
1999-2001
Goethe University Frankfurt
1999-2001
Paul Scherrer Institute
2001
Sudbury Regional Hospital
1991
Penn State Milton S. Hershey Medical Center
1983
Background In patients with significant functional tricuspid regurgitation, timely detection of right ventricular (RV) dysfunction conventional 2-dimensional echocardiography is challenging, whereas speckle-tracking RV free wall longitudinal strain has been proposed as better prognosticator. We evaluated the prevalence and prognostic value impaired in comparison annular plane systolic excursion (TAPSE) fractional area change (FAC). Methods Eight hundred ninety-six (51.3% men, 71 years [62-78...
Background: In patients with significant (moderate and severe) tricuspid regurgitation (TR), the decision to intervene is influenced by right ventricular (RV) size function. RV remodeling in secondary TR has been underexplored. The aim of this study was characterize investigate its prognostic implications. Methods: characterized transthoracic echocardiography 1292 (median age 71 [62–78]; 50% male). Four patterns were defined according presence dilation (tricuspid annulus≥40 mm) systolic...
Atrial functional tricuspid regurgitation (atrial TR) has received growing recognition as a TR entity with distinct cause owing to its independence from valvular tethering the predominant mechanism underlying TR. However, characterization of atrial varies, and universal definition is lacking.In total, 651 patients significant were analyzed, including 438 conservatively treated individuals 213 who transcatheter valve repair (TTVR). Based on clustering approach, we defined (TV) tenting height...
Atrial functional tricuspid regurgitation (AFTR) has shown distinctive pathophysiological and anatomical differences compared with ventricular (VFTR) potential implications for interventions. However, little is known about the difference in long-term prognosis between these two FTR-aetiologies, which was investigated current study.Patients severe FTR were divided into aetiologies, based on echocardiography: AFTR VFTR. VFTR further subdivided (i) left-sided cardiac disease; (ii) pulmonary...
This study evaluated the prognostic value of staging right heart failure in patients with significant tricuspid regurgitation (TR) undergoing valve (TV) surgery.Patients TR who underwent TV surgery were divided into 4 stages according to presence ventricular (RV) dysfunction and clinical signs failure: stage 1 was defined as no RV failure; 2 indicated without 3 included refractory at rest.A total 278 [mean age 64 (12), 49% males] included, whom 34 (12%) classified 2, 141 (51%) 103 (37%)...
The prognostic impact of isolated tricuspid regurgitation (TR) in patients with atrial fibrillation (AF) has not been investigated. purpose this study was to investigate the implications significant TR AF without left-sided heart disease, pulmonary hypertension, or primary structural abnormalities valve.A total 63 moderate and severe were matched for age gender 116 TR. Patients followed occurrence all-cause mortality, hospitalization failure stroke. (mean 71 ± 8 years, 57% men) more often...
Secondary tricuspid regurgitation (TR) imposes a chronic volume overload on the right ventricle (RV) which can increase RV wall tension (RVWT). The aim of this study was to investigate prognostic implications increased RVWT in patients with significant secondary TR. A total 1,142 moderate-to-severe TR were included. Based simplified Laplace-Young's law, defined as product between pulmonary artery systolic pressure (PASP) and base-to-apex length. association risk all-cause death identified...
Objective Severe secondary tricuspid regurgitation (STR) causes significant right atrial (RA) volume overload, resulting in structural and functional RA-remodelling. This study evaluated whether patients with severe STR reduced RA function, as assessed by RA-reservoir-strain (RASr), show lower long-term prognosis. Methods Consecutive patients, from a single centre, first diagnosis of RASr measure available, were included. Extensive echocardiographic analysis comprised measures cardiac...
The pathophysiological mechanisms linking tricuspid regurgitation (TR) and chronic kidney disease (CKD) remain unknown. This study aimed to determine which related TR are independently associated with renal dysfunction evaluate the impact of impairment on long-term prognosis in patients significant (≥ moderate) secondary TR.
Assessment of right ventricular (RV) systolic function in patients with significant secondary tricuspid regurgitation (STR) remains challenging. In severe aortic stenosis treated transcatheter valve implantation (TAVI), STR and RV enlargement have been associated poor outcomes. these patients, speckle tracking echocardiography (STE) may detect dysfunction better than 3-dimensional (3D) ejection fraction (EF). The purpose this study was to investigate the prevalence when assessed STE (≥3+)...
Conventional approaches for the assessment of secondary tricuspid regurgitation (STR) severity do not correct right heart dimensions. The authors hypothesized that STR can be proportional or disproportional to dilation annulus (TA) and investigated prognostic impact this novel definition.A total 334 patients with moderate severe preserved left ventricular systolic function were included. ratio between vena contracta (VC) width annular diameter was calculated. cutoff value VC/TA associated...
Objective Parameters of a pharmacokinetic‐pharmacodynamic (PK‐PD) model levodopa have been claimed to reflect the magnitude dopaminergic deficit in patients with Parkinson's disease. The aim this study was correlate such parameters positron emission tomography (PET) tagged 6‐fluorine 18, an established imaging method for striatal neurons. Methods Twenty‐three different disease stages (Hoehm and Yahr stage 2.5–5 [Hoehn MM, MD. Parkinsonism: onset, progression mortality. Neurology...
•Obesity is associated with RV dilation in patients TR.•RV function similar across BMI groups.•Higher related to fewer events significant TR.•This confirms the obesity paradox TR. BackgroundObesity may cause right ventricular (RV) remodeling due volume overload. However, also better prognosis compared normal weight various cardiac diseases. The aim of this study was assess impact on and long-term (moderate severe) tricuspid regurgitation (TR).MethodsA total 951 TR (median age, 70 years;...
In patients with primary mitral regurgitation (MR), concomitant tricuspid valve (TV) annuloplasty at the time of left-sided surgery is indicated in case a dilated TV annulus ≥40 mm independent presence or severity (TR). However, long-term impact on right ventricular (RV) adverse remodeling less well established and benefit preventive remains controversial. The aim study was to assess differences RV development significant TR those patients. total, 98 (mean age 65 ± 11 years, 85% men) MR...
Abstract Introduction Severe tricuspid regurgitation (TR) is associated with increased mortality if left untreated. Recently, the Tricuspid Valve Academic Research Consortium (TVARC) has published standardized definitions of disease aetiology and severity, as well endpoints for future clinical trials. Right ventricular (RV) function assessment represents one cornerstones risk stratification in these patients, but current guidelines do not propose specific cut-off values echocardiographic...
Abstract Funding Acknowledgements Type of funding sources: None. Background Atrial functional tricuspid regurgitation (A-FTR), defined as TR due to prominent right atrial (RA) dilatation without significant ventricular (RV) remodelling, has recently emerged a distinct subtype FTR, and can be distinguished from FTR (V-FTR), by RV remodelling leading annular leaflet tethering. However, so far no data been reported on the values RA strain in these patients. Purpose To evaluate potential...
Numerous studies have shown that a substantial number of patients suffer from adverse events (AEs) as result hospital care. However, specific data on AEs in acute cardiac care are scarce. The current manuscript describes the development and validation instrument to evaluate patient safety predefined track for with myocardial infarction (AMI).Retrospective record review study.A total 879 admissions treated tertiary centre an AMI (age 64±12 years, 71% male).In first phase, medical records...