A5001698970- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Genetics and Neurodevelopmental Disorders
- Peroxisome Proliferator-Activated Receptors
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Metabolism, Diabetes, and Cancer
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Dietary Effects on Health
- Infant Nutrition and Health
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Cellular transport and secretion
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
Max Planck Institute for Multidisciplinary Sciences
2022-2023
National Chung Hsing University
2022
Trinity College Dublin
2015-2022
Leibniz Association
2022
National University of Singapore
2022
Smith College
2022
Heidelberg University
2022
University Medical Center of the Johannes Gutenberg University Mainz
2022
Johannes Gutenberg University Mainz
2022
German Cancer Research Center
2022
Blocking interaction of the immune checkpoint receptor PD-1 with its ligand PD-L1 is associated good clinical outcomes in a broad variety malignancies. High levels promote tumour growth by restraining CD8+ T-cell responses against tumors. Limiting expression and function therefore critical for allowing development anti-tumour effective clearance. PKM2 also key player regulating cancer as well responses. catalyzes final rate-limiting step glycolysis. Furthermore dimer translocates to nucleus,...
Tumor cells secrete not only a variety of soluble factors, but also extracellular vesicles that are known to support the establishment favorable tumor niche by influencing surrounding stroma cells.Here we show tumor-derived microvesicles (T-MV) directly influence enhancing their invasion in both autologous and heterologous manner.Neither respective vesicle-free supernatant nor MV from benign mammary mediate invasion.Uptake T-MV is essential for proinvasive effect.We further identify highly...
Obesity is one of the leading preventable causes cancer; however, little known about effects obesity on anti-tumor immunity. Here, we investigated CD8 T cells in mouse models and patients with endometrial cancer. Our findings revealed that cell infiltration suppressed obesity, which was associated a decrease chemokine production. Tumor-resident were also functionally obese mice, suppression amino acid metabolism. Similarly, found high BMI negatively correlated human cancer weight loss...
Abstract Cancer cells that are resistant to Bax/Bak-dependent intrinsic apoptosis can be eliminated by proteasome inhibition. Here, we show inhibition induces the formation of high molecular weight platforms in cytosol serve activate caspase-8. The activation complexes contain Fas-associated death domain (FADD) and receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Furthermore, TRAIL-receptor 2 (TRAIL-R2) but not (TRAIL-R1). While RIPK1 or depletion did affect inhibitor-induced...
Neuroligin-3 is a postsynaptic adhesion molecule involved in synapse development and function. It implicated rare, monogenic forms of autism, its shedding critical to the tumor microenvironment gliomas. While other members neuroligin family exhibit synapse-type specificity localization function through distinct interactions with scaffold proteins, neuroligin-3 synaptic remains largely unknown.
ABSTRACT Neuroligin-3 is a postsynaptic adhesion molecule involved in development, function, and pathologies of synapses the brain. It genetic cause autism potent component tumor microenvironment gliomas. There are four Neuroligins that operate at distinct synapse types, selectively interacting with presynaptic scaffold proteins. We investigated subcellular localization specificities synaptic demonstrate an unexpected pattern to excitatory cortical areas, inhibitory subcortical areas. Using...
Abstract BAMLET, a bovine α-lactalbumin - oleic acid complex, is novel and promising candidate for the treatment of cancer because its capacity to specifically kill tumor cells while leaving normal tissues relatively unharmed. While recent studies focused on direct tumoricidal effects we investigated potential BAMLET modulate anti-tumor immune responses, in combination with TLR7 agonist R848, which stimulates innate adaptive immunity. Consistent previous studies, induced killing B16 melanoma...
<h3>Objectives</h3> Endometrial cancer is the most common of female reproductive tract, and obesity greatest risk factor for endometrial cancer. We have recently found that in addition to enhancing tumor growth, also impairs anti-tumor immune response. Here, we investigated effect weight loss on landscape tumor, during an interventional treatment patients. <h3>Methods</h3> Metabolic surgery was performed 12 patients deemed suitable (>18 years, BMI 40 kg/m2 diagnosis grade 1 or 2...
Abstract Introduction Selection criteria for immunotherapy with checkpoint blockade in colorectal cancer are currently based on mismatch repair status. However, intra-tumoral T cell response varies among patients the same MMR Inhibitory expression tumour-infiltrating lymphocytes microsatellite stable and unstable CRC is unknown. Method Flow cytometric analysis single-cell RNA sequencing, using 10x genomic platform, were performed ex vivo tumour uninvolved colonic tissue samples from...