A5021858189- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Cardiac Ischemia and Reperfusion
- Cardiac tumors and thrombi
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular and Diving-Related Complications
- Ion channel regulation and function
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Mechanical Circulatory Support Devices
- Heat shock proteins research
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac Fibrosis and Remodeling
University of Göttingen
2009-2020
Nephrologisches Zentrum Goettingen
2019
Universitätsmedizin Göttingen
2009-2018
German Centre for Cardiovascular Research
2017
University of Kentucky
2004
Tufts Medical Center
2004
University of Vermont
2003-2004
The influence of age on baseline demographics and outcomes patients selected for MitraClip has not been previously investigated.Baseline acute in 1,064 from the German TRAMI registry were stratified by (525 ≥76 years 539 <76 years). In elderly patients, logistic EuroSCORE was higher (25[15-40]% vs. 18[10-31]%, p<0.0001) proportion women greater (47.2% 29.3%, p<0.0001). Elderly more likely to have preserved left ventricular ejection fraction >50% (40.1% 21.8%, degenerative mitral...
Transcatheter aortic valve implantation (TAVI) represents a less invasive treatment option for elderly patients. Therefore, we aimed to determine the impact of frailty measured by Katz Index activities daily living (ADL) on short- and long-term mortality after TAVI.Our study included 300 consecutive patients (mean age, 82±5 years) who had undergone TAVI at our institution (158 transapical, 142 transfemoral procedures). At baseline, 144 were impaired in least one ADL therefore defined as...
Transcatheter aortic valve implantation (TAVI) has recently developed into an accepted alternative to conventional surgery in high-risk patients. According current data, post-TAVI prosthetic endocarditis (PVE) seems occur very rarely.We followed the first 180 consecutive patients who underwent TAVI at our institution assess safety and efficacy of procedure. During follow-up (median, 319 days), PVE was seen more frequently than expected. By applying modified Duke criteria five cases could be...
Aims Mitral valve regurgitation plays a significant role in the aetiology and course of heart failure. We investigated impact learning curve on outcomes after percutaneous mitral repair with MitraClip. Methods results Outcomes first 75 consecutive patients treated MitraClip at our centre were stratified by subsequent treatment periods (25 each). Median total procedure time device decreased from 180 105 min period 1 to 95 55 3 (P < 0.005 There was an excess safety events (n = 16) that 2 6 3,...
MitraClip implantation is evolving as a potential alternative treatment to conventional surgery in high-risk patients with significant mitral regurgitation (MR). However, outcome predictors are under-investigated. The aim of this study was identify midterm mortality and heart failure rehospitalisation after percutaneous valve repair MitraClip.A total 150 consecutive were followed for median 463 days. Survival analyses performed baseline characteristics, risk scores acute procedural success...
Background — Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics patients with congestive heart failure. We assessed the influence on systolic diastolic myocardial its subcellular mode action from end-stage failing human hearts. Methods Results In muscle strip preparations, concentration-dependent effects developed force (n=6), aequorin light emission reflecting intracellular Ca 2+ transients rapid cooling contractures sarcoplasmic...
While early pneumonia is common in patients after out-of-hospital cardiac arrest (OHCA), little known about the impact of and optimal timing antibiotic therapy OHCA.We conducted a 5-year retrospective cohort study, including who suffered from OHCA were treated with therapeutic hypothermia. ICU treatment was strictly standardized defined goals procedures. Medical records, chest radiographic images microbiological findings reviewed.Within study period, 442 admitted to our medical successfully...
Background— The contribution of the sarcomere’s thin filament to contractile dysfunction human cardiomyopathy is not well understood. Methods and Results— We have developed techniques isolate functionally characterize intact (native) filaments obtained from failing nonfailing ventricular tissue. By use in vitro motility force assays, native tissue exhibited a 19% increase maximal velocity but 27% decrease compared with myocardium. Native isolated myocardium after left assist device support...
Ionizing radiation (IR) is an integral part of modern multimodal anti-cancer therapies. IR involves the formation reactive oxygen species (ROS) in targeted tissues. This associated with subsequent cardiac dysfunction when applied during chest radiotherapy. We hypothesized that (i.e., ROS)-dependently impaired myocytes' Ca handling might contribute to IR-dependent cardiocellular dysfunction. Isolated ventricular mouse myocytes and mediastinal area anaesthetized mice (that included heart) were...
Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced pressure overload by transthoracic aortic constriction (TAC) or volume aortocaval shunt D2-expressing and WT mice. Although expression dramatically improved survival following TAC, it did not confer a advantage shunt. Cardiac function decreased TAC...
Pyruvate was shown to increase cardiac performance in isolated human and animal myocardium patients with chronic heart failure. We sought investigate the effects of pyruvate acute failure.Patients presenting cardiogenic shock because myocardial infarction were subjected standard care primary PCI intra-aortic balloon pump (IABP). Then, a Swan-Ganz catheter placed pulmonary artery hemodynamics analyzed before, during after intracoronary administration 300 mmol/L (360 ml/h). induced significant...
Positive results of MitraClip in terms improvement clinical and left ventricular parameters have been described detail. However, long-term effects on secondary pulmonary hypertension were not investigated a larger patient cohort to date. 70 patients with severe mitral regurgitation, additional hypertension, right heart failure as result disease treated the centers Hamburg Göttingen. Immediately after successful implantation, reduction RVOT diameter from 3.52 cm 3.44 was observed reaching...
Reports on cardiac problems with oral proton pump inhibitors have caused extensive safety reviews by the US Food and Drug Administration. We provide additional data acute effects of an intravenous application.
We tested the hypothesis that economy and efficiency are independent of length in intact cardiac muscle over its normal working range. measured force, force-time integral, force-length area, myocardial oxygen consumption eight isometrically contracting rabbit right ventricular papillary muscles. 2,3-Butanedione monoxime was used to partition nonbasal into tension-independent tension-dependent components. Developed area increased by factors 2.4, 2.7, 4.8, respectively, as from 90% 100%...
Sirs, Sudden cardiac arrest is a leading cause of death in developed nations and about 40% victims present with ventricular fibrillation at the time first heart rhythm analysis [4]. Acute myocardial ischemia generally considered to be most common factor triggering fatal arrhythmias [5]. We report rare case sudden due patient whom diagnostic follow-up led diagnosis primary lymphoma (PCL).
<b>Hintergrund: </b>Zur Behandlung von Patienten mit nachweisbaren Transit-Thromben gibt es wenig Evidenz. Berichtet wird hier über drei konsekutive Patientinnen akuter Lungenembolie und gleichzeitigem Nachweis flottierender rechtskardialer Raumforderungen. <b>Anamnese klinischer Befund: </b>Drei im Alter 75, 72 52 Jahren wurden innerhalb 3 Monaten progedienter Dyspnoesymptomatik V. a. in unserem Haus stationär aufgenommen. <b>Untersuchungen: </b>In allen Fällen erfolgte der...
Nitric oxide (NO) has influence on various cellular functions. Little is known of the NO myocardial energetics. In present study oxygen consumption and mechanical parameters isometrically contracting rabbit papillary muscles (1 Hz stimulation frequency) were investigated at varying interventions while maintaining physiological conditions (37 degrees C; 2.5 mM Ca(2+)) to effects The donor sodium nitroprusside (SNP) showed a negative inotropic effect. SNP decreased maximal force in normal...