A5017232900- Bone fractures and treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- Orthopedic Surgery and Rehabilitation
- Ovarian function and disorders
- Shoulder Injury and Treatment
- Elbow and Forearm Trauma Treatment
- Shoulder and Clavicle Injuries
- Orthopedic Infections and Treatments
- Medical Practices and Rehabilitation
- Tracheal and airway disorders
- Trauma Management and Diagnosis
- Reproductive Health and Technologies
- Cardiac electrophysiology and arrhythmias
- Voice and Speech Disorders
- Reproductive Physiology in Livestock
- Infectious Diseases and Tuberculosis
- Hip disorders and treatments
- Head and Neck Surgical Oncology
- Ectopic Pregnancy Diagnosis and Management
- Cervical Cancer and HPV Research
- Genetic and phenotypic traits in livestock
- Prenatal Screening and Diagnostics
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
University Hospital Schleswig-Holstein
2016-2022
University of Lübeck
2016-2022
Universitäres Kinderwunschzentrum Lübeck
2017-2021
Orthopädische Praxis
2021
Klinik für Frauenheilkunde
2020
Technical University of Applied Sciences Lübeck
2017
Saarland University
2014
German Centre for Cardiovascular Research
2014
Heart Foundation
2014
Heidelberg University
2009-2014
Although research suggests that diastolic Ca(2+) levels might be increased in atrial fibrillation (AF), this hypothesis has never been tested. Diastolic leak from the sarcoplasmic reticulum (SR) increase and play a role triggering or maintaining AF by transient inward currents through Na(+)/Ca(2+) exchange. In ventricular myocardium, ryanodine receptor type 2 (RyR2) phosphorylation Ca(2+)/calmodulin-dependent protein kinase (CaMK)II is emerging as an important mechanism for SR leak.We tested...
Background— Transgenic (TG) Ca/calmodulin-dependent protein kinase II (CaMKII)δ C mice have heart failure and isoproterenol (ISO)-inducible arrhythmias. We hypothesized that CaMKII contributes to arrhythmias underlying cellular events inhibition of reduces cardiac arrhythmogenesis in vitro vivo. Methods Results— Under baseline conditions, isolated myocytes from TG showed an increased incidence early afterdepolarizations compared with wild-type ( P <0.05). (AIP) completely abolished these...
Background— Ca 2+ -dependent signaling through CaM Kinase II (CaMKII) and calcineurin was suggested to contribute adverse cardiac remodeling. However, the relative importance of CaMKII versus for remodeling remained unclear. Methods Results— We generated double-knockout mice (DKO) lacking 2 genes δ γ specifically in cardiomyocytes. show that both isoforms redundantly phosphorylation not only phospholamban, ryanodine receptor 2, histone deacetylase 4, but also calcineurin. Under baseline...
Twenty-four unicondylar fractures of the distal femur were treated at Trauma Center "Bergmannsheil," University Bochum, Germany, between 1981 and 1990. All patients sustained their injuries from severe direct trauma. There 16 lateral condylar fractures, five medial three tangential posterior ("Hoffa-type") fractures. Twenty-three closed one grade IIIB open fracture are included. Nine (37.5%) concomitant to skeleton. with reduction internal fixation screws within 8 h admission. Postoperative...
Use of real-time ultrasonography in meat animal improvement programs has increased largely as a result the perceived accuracy such instruments measuring longissimus muscle area (LMA) and fat depth (BF). The objective this study was to examine operator effects for ultrasonic determination BF LMA market-weight cattle, sheep pigs. day prior slaughter, five persons scanned 45 pigs, 32 18 cattle at last rib using an A-mode Ithaco Model 731AM101 body composition meter (ABF) Johnson Ultrasound...
What are the plasma concentrations of dydrogesterone (DYD) and its metabolite, 20α-dihydrodydrogesterone (DHD), measured on day embryo transfer (ET) in programmed anovulatory frozen (FET) cycles using 10 mg per os ter-in-die (tid) oral DYD, what is association DYD DHD levels with ongoing pregnancy rate?DYD reach steady state by Day 3 intake, strongly correlated vary considerably between within individual subjects, women lowest quarter or FET have a reduced chance an pregnancy.DYD oral,...
Ionizing radiation (IR) is an integral part of modern multimodal anti-cancer therapies. IR involves the formation reactive oxygen species (ROS) in targeted tissues. This associated with subsequent cardiac dysfunction when applied during chest radiotherapy. We hypothesized that (i.e., ROS)-dependently impaired myocytes' Ca handling might contribute to IR-dependent cardiocellular dysfunction. Isolated ventricular mouse myocytes and mediastinal area anaesthetized mice (that included heart) were...
Objective What are the cost per live birth and incremental of preventing a miscarriage with preimplantation genetic testing for aneuploidy (PGT‐A) by polar body biopsy array‐based comprehensive genome hybridisation (aCGH) versus regular IVF/ICSI without PGT‐A infertility treatment in women 36–40 years age? Design Decision tree model. Population A randomised clinical trial on (ESTEEM study). Methods Two strategies were compared: one cycle or PGT‐A. Costs effects analysed this model four...
What are outcome and procedural differences when using the semi-automated closed Gavi® device versus manual open Cryotop® method for vitrification of pronuclear (2PN) stage oocytes within an IVF program?A gives similar clinical results as compared to exclusively manual, system but higher procedure duration less staff convenience.A has been introduced market, however, little evaluation its performance in a setting conducted so far.This prospective, randomised, non-inferiority trial was at...
Ziel: Das Ziel dieser Studie war, die Vorhersagegenauigkeit der präoperativen CT-Volumetrie für das verdrängungsvolumetrisch ermittelte Lebervolumen nach Lebertransplantation zu prüfen. Methodik: In einer retrospektiven wurde bei 52 Patienten vor auf Basis von Inkremental- und Spiral-CT-Untersuchungen mit unterschiedlichen Schwellenwertbereichen berechnet. Die ermittelten Werte wurden dem am Operationspräparat gemessenen verglichen. Ergebnisse: Für Gesamtkollektiv zeigten sich große...
Purpose: to evaluate functional MR imaging in patients with rheumatoid arthritis (RA) involving the cervical spine Material and Methods: We used a device that allows examination be made of infinitely variable degrees flexion extension. Dynamic was performed on 25 RA Results: Functional able show degree vertebral instability occipito-atlantal or atlanto-axial level as well subaxial level. by performing imaging, we were demonstrate extent synovial tissue around dens, impingement displacement...
Hintergrund: Die Therapie der Schädelbasis osteomyelitis (SBO) stellt nach wie vor eine Herausforderung dar. Standardtherapie umfasst die zielgerichtete Antibiose, Lokaltherapie und chirurgische Entfernung des nekrotischen Knochens. Diese Studie untersucht den Nutzen einer adjuvanten HBO-Therapie unter besonderer Beachtung funktionellen Ergebnisses. Weiterhin wird Wertigkeit einzelnen bildgebenden Verfahren untersucht.
Data from the World Health Organization (WHO) demonstrates an increasing prevalence of obesity in Western countries. This study investigates influence on mode delivery and occurrence hypoglycemia newborns.A retrospective analysis all deliveries at Department Gynecology Obstetrics University Lübeck, Germany was conducted over a period eleven years with primary outcome as non-elective C-sections newborns obese mothers. Patients were divided into six subgroups according to WHO weight...
Background The randomized ESTEEM trial reported that preimplantation genetic aneuploidy testing of oocytes by polar body biopsy (PGT-A) with array comparative genomic hybridization (aCGH) in women aged 36 - 40 years undergoing assisted reproduction treatment reduces the number embryo transfers and risk miscarriage while not impacting live birth rate. Method A decision tree model based on data from was created analyzed, using three cost scenarios for Germany (statutory health insurance [GKV]...