A5046021654- Neurobiology of Language and Bilingualism
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Action Observation and Synchronization
- Acute Ischemic Stroke Management
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Music Perception
- Vestibular and auditory disorders
- Spatial Neglect and Hemispheric Dysfunction
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Telemedicine and Telehealth Implementation
- Cerebral Palsy and Movement Disorders
- Advanced Neuroimaging Techniques and Applications
- Spatial Cognition and Navigation
- Photoreceptor and optogenetics research
- Artificial Intelligence in Healthcare and Education
- Cognitive Abilities and Testing
- Machine Learning in Healthcare
- Musculoskeletal pain and rehabilitation
- Hearing Loss and Rehabilitation
- Diverse Music Education Insights
- Diet and metabolism studies
Johns Hopkins University
2011-2023
Johns Hopkins Medicine
2017-2023
Medical University of South Carolina
2022
University of South Carolina
2022
Linus (Norway)
2022
Berenson Allen Center for Noninvasive Brain Stimulation
2016-2021
Beth Israel Deaconess Medical Center
2016-2021
Neurology, Inc
2020
Google (United States)
2018
University of Maryland, College Park
2014-2016
Objective Many stroke patients show remarkable recovery of language after initial severe impairment, but it is difficult to predict which will good recovery. We aimed identify patient and lesion characteristics that together the best naming outcome in 4 studies. Methods report 2 longitudinal studies identified variables at onset were strongly associated with (the most common residual deficit aphasia) first 6 months stroke: damage left posterior superior temporal gyrus (pSTG) and/or...
People with post-stroke aphasia may have some degree of chronic deficit for which current rehabilitative treatments are variably effective. Accumulating evidence suggests that transcranial direct stimulation (tDCS) be useful enhancing the effects behavioral treatment. However, it remains unclear brain regions should stimulated to optimize on language recovery. Here, we report therapeutic potential right cerebellar tDCS in augmenting recovery SMY, who sustained bilateral MCA infarct resulting...
Purpose Our goal was to evaluate an updated version of the “Cookie Theft” picture by obtaining norms based on descriptions healthy controls for total content units (CUs), syllables per CU, and ratio left–right CUs. In addition, we aimed compare these measures from obtained individuals with poststroke aphasia primary progressive (PPA) assess whether can capture impairments in efficiency communication. Method Using this picture, analyzed 50 develop numbers syllables, CUs, CU. We provide...
Background: Post-stroke aphasia is a chronic condition that impacts people's daily functioning and communication for many years after stroke. Even though these individuals require sustained rehabilitation, they face extra burdens to access care due shortages in qualified clinicians, insurance limitations geographic access. There need research alternative means intervention remotely, such as the case of this study using digital therapeutic. Objective: To assess feasibility clinical efficacy...
Type-2 diabetes mellitus (T2DM) accelerates cognitive aging and increases risk of Alzheimer's disease. Rodent models T2DM show altered synaptic plasticity associated with reduced learning memory. Humans also deficits, including memory, but the relationship these impairments to efficacy neuroplastic mechanisms has never been assessed.Our primary objective was compare cortical in humans without T2DM. Our secondary relate measures standard cognition.A prospective cross-sectional cohort study...
Impaired expression of emotion through pitch, loudness, rate, and rhythm speech (affective prosody) is common disabling after right hemisphere (RH) stroke. These deficits impede all social interactions. Previous studies have identified cortical areas associated with impairments expression, recognition, or repetition affective prosody, but not critical white matter tracts. We hypothesized that: 1) differences across patients in specific acoustic features correlate listener judgment prosody...
Hemispatial neglect is a heterogeneous and complex disorder that can be classified by frame of reference for "left" vs "right," including viewer-centered (VCN, affecting the contralesional side view), stimulus-centered (SCN, stimulus, irrespective its location with respect to viewer), or both. We investigated effect acute stroke lesions on connectivity neural networks underlie VCN SCN.
For stroke, traumatic brain injury (TBI), and other neurologic conditions associated with speech-language disorders, speech language therapy is the standard of care for promoting recovery. However, barriers such as clinician time constraints insurance reimbursement can inhibit a patient's ability to receive support needed optimize functional gain. Although digital rehabilitation has potential increase access by allowing patients practice at home, clinical demographic characteristics that...
<h3>Objective</h3> To test the hypothesis that severity of leukoaraiosis in noninfarcted hemisphere at onset is associated with poorer language outcome after poststroke aphasia independently volume infarct, damage to 3 critical areas (left inferior frontal gyrus, superior longitudinal fasciculus, and temporal gyrus), comorbid conditions, time since stroke. <h3>Methods</h3> In this cross-sectional study, we evaluated naming (>3 months stroke) 42 individuals who initially had We rated right...
To determine whether right ventral stream and limbic structures (including posterior superior temporal gyrus [STG], STG, pole, inferior frontal pars orbitalis, orbitofrontal cortex, amygdala, anterior cingulate, gyrus, the sagittal stratum) are implicated in emotional prosody identification.Patients with MRI scans within 48 hours of unilateral hemisphere ischemic stroke were enrolled. Participants presented 24 sentences neutral semantic content spoken happy, sad, angry, afraid, surprised, or...
Abstract BACKGROUND Gene fusion between TMPRSS2 promoter and the ERG proto‐oncogene is a major genomic alteration found in over half of prostate cancers (CaP), which leads to aberrant androgen dependent expression. Despite extensive analysis for biological functions CaP, there no systematic evaluation responsive proteome (ERP). ERP has potential define new biomarkers therapeutic targets tumors stratified by METHODS Global was performed using (+) (−) CaP cells isolated immunohistochemistry...
Evidence for shared processing of structure (or syntax) in language and music conflicts with neuropsychological dissociations between the two. However, while harmonic structural can be impaired patients spared linguistic syntactic abilities (Peretz, I. (1993). Auditory atonalia melodies. Cognitive Neuropsychology, 10, 21–56. doi:10.1080/02643299308253455), evidence opposite dissociation–preserved despite agrammatism–is largely lacking. Here, we report one such case: HV, a former musician...
Background The relationship between structural processing in music and language can be viewed from two perspectives: whether the neural of recruits shared resources, musical ability is associated with neuroplastic resilience against impairment.Aims This study investigated persons who developed aphasia (PWA) following left-hemisphere stroke, asked three questions: (1) structure compromised PWA, (2) there a linguistic structure, (3) if prior post-stroke task performance.Methods & Procedures...
Alzheimer's disease (AD) and type 2 diabetes (T2DM) are common causes of cognitive decline among older adults share strong epidemiological links. Distinct patterns cortical atrophy observed in AD T2DM, but robust comparisons between structure-function relationships across these two states lacking. To compare how within distributed brain networks is related to cognition the spectrum aging. The relationship structural MRI changes was studied 22 mild-to-moderate AD, 28 27 healthy participants....
Introduction: As the population ages, prevalence of cognitive impairment is expanding. Given recent pandemic, there a need for remote testing modalities to assess deficits in individuals with neurological disorders. Self-administered, remote, tablet-based assessments would be clinically valuable if they can detect and classify as effectively traditional in-person neuropsychological testing. Methods: We tested whether Miro application, neurocognitive platform, measured same domains...
While language characteristics of logopenic variant primary progressive aphasia (lvPPA) are well-defined, behavioral less understood. We investigated correlations between and scores across three variants (PPA) found performance disturbances correlated in lvPPA, but not other PPA subtypes. Results suggest that unlike variants, patients diagnosed with lvPPA do develop negative behaviors until deficits severe. This is consistent the underlying neuropathology Alzheimer's Disease. Such findings...
Background: It is estimated that ∼30% of stroke survivors have aphasia, a language disorder resulting from damage to left-hemisphere networks. In acute care settings, efficient identification aphasia critical, but there paucity bedside assessments. Objective: To determine whether objective measures on picture description task administered within 48 hours post (a) predict recovery, (b) estimate lesion volume and location, (c) correlate with other Method: Behavioral data were scored at chronic...
The behavioral state of a subject is hypothesized to be reflected in the oscillatory modulations spiking activity certain groups neurons. In particular, beta- and gamma-bands have been experimentally shown related movement motor cortex parts basal ganglia. Here, we analyze relationship between directional tuning oscillations neurons Globus Pallidus internus (GPi) two healthy nonhuman primates during radial center-out task. We find that, planning stages movement, percentage directionally...
Event Abstract Back to Cookie Theft Picture Description: Linguistic and Neural Correlates Lynsey M. Keator1*, Shannon Sheppard1, Andreia V. Faria2, Kevin Kim1, Sadhvi Saxena1, Amy Wright1 Argye E. Hillis1, 2, 3, 4 1 Johns Hopkins Medicine, Neurology, United States 2 University, The Russell H Morgan Department of Radiology Radiological Science, 3 Physical Medicine Rehabilitation, Cognitive Problem/Hypothesis: Expressive language deficits, such as word finding, are common following a stroke...