A5048753757- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Folate and B Vitamins Research
- Phytochemicals and Antioxidant Activities
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Tea Polyphenols and Effects
- Fatty Acid Research and Health
- Regulation of Appetite and Obesity
- Tannin, Tannase and Anticancer Activities
- Phosphodiesterase function and regulation
- Histone Deacetylase Inhibitors Research
- Vitamin C and Antioxidants Research
- Immune Cell Function and Interaction
- Lipid metabolism and biosynthesis
- Vitamin D Research Studies
- Tryptophan and brain disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Kyushu University
2010-2024
Hokkaido University
1990-2023
New York University Press
2023
Cambridge University Press
2023
National Cerebral and Cardiovascular Center
2017
Waseda University
2007
There is an increasing need to explore the mechanism of progression non-alcoholic fatty liver disease. Steroid metabolism closely linked hepatic steatosis and steroids are excreted as bile acids (BAs). Here, we demonstrated that feeding WKAH/HkmSlc inbred rats a diet supplemented with cholic acid (CA) at 0.5 g/kg for 13 weeks induced simple without obesity. Liver triglyceride cholesterol levels were increased accompanied by mild elevation aminotransferase activities. no signs inflammation,...
For HTS (high-temperature superconductor) applications to electric power devices, superconductors are subjected short-circuit fault currents 10 30 times the normal operating current. These over-currents will drive conductors and degrade or burn-out conductors. Therefore it is important establish a novel thermal stability criterion for over-current pulse drive. In this study, we carried out preliminary experiments on damage caused by focusing limitation of temperature rise without...
Abstract Soyasaponins are triterpenoid glycosides found in soybean. We investigated whether soyasaponin ameliorates lipid metabolism and its possible mechanisms. In C57BL/6J mice fed a high‐fat diet (HFD), (SAP) was orally administered for 9 weeks. Additionally, we evaluated the effect of soyasapogenols on 3T3‐L1 adipocytes. HFD‐fed mice, SAP significantly reduced body weight by 7% relative adipose tissue 35%. X‐ray computed tomography demonstrated that visceral subcutaneous weights during...
Kurozu concentrated liquid (KCL) is used as a health-promoting supplement for the treatment of disorders such cancer, hyperlipidemia, and hypertension in Japan. We investigated possible anti-obesity effects KCL rats.Male Sprague Dawley rats were fed American Institute Nutrition 76 formula diet orally administrated or acetic acid at dose 100 mg/kg body weight deionized water 4 weeks. Adipocyte size, DNA content subcutaneous adipose tissue, lipid levels serum liver, rate fatty excretion...
The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling pathway plays a fundamental role in modulating diverse physiological processes including blood flow, fibrosis, inflammation, and metabolism.sGC stimulators are small-molecule, heme-dependent agonists of sGC that synergize with enhance endogenous NO signaling.As such, may provide therapeutic benefits both diseases associated impaired signaling where stimulation this will restore functional...
Difructose anhydride III (DFAIII) is a prebiotic involved in the reduction of secondary bile acids (BAs). We investigated whether DFAIII modulates BA metabolism, including enterohepatic circulation, rats fed with diet supplemented cholic acid (CA), one 12α-hydroxylated BAs. After acclimation, were control or DFAIII. 2 weeks, each group was further divided into two groups and without CA supplementation at 0.5 g/kg diet. levels analyzed aortic portal plasma, liver, intestinal content, feces....
Abstract We previously reported that dietary supplementation with cholic acid (CA), the primary 12α-hydroxylated (12αOH) bile (BA), reduces plasma adiponectin concentration in rats. The aim of this study was to examine distribution body CA-fed rats and its influence on mucosal immunoglobulin A intestine. Rats were fed a diet supplemented or without CA (0.5 g CA/kg diet) for 13 weeks. reduction level observed from week 3. At end experiment, reduced both portal aortic plasma. Accumulation...
Abstract Linoleic acid (LA) has a two-sided effect with regard to serum cholesterol-lowering and pro-inflammation, although whether this fatty reduces cholesterol the development of atherosclerosis under high-cholesterol conditions yet be ascertained. In study, we examine effects dietary LA on reducing conditions. Male female apoE-deficient (ApoE -/ -) mice were fed AIN-76-based diets containing 10% SFA 0·04 % cholesterol, 0·04% low (LALC), or 0·1% high (LAHC) for 9 weeks. The results...
Egg yolk is an important source of nutrients and contains different bioactive substances. In the present study, we studied benefits egg in preventing low-protein-diet-induced fatty liver rats. Rats were fed following diets, which based on AIN-76 formula, for 2 wk: adequate-protein diet containing 20% casein (C), a low-protein 5% (LP-C), supplemented with 12.5% (LP-EY), 4.1% oil (LP-EYO). The diets adjusted to contain 4.13% protein 4.7% lipids. LP-C resulted greater increase trigriceride (TG)...
Rice α-globulin has been reported to have serum cholesterol-lowering activity in rats. However, it is still unclear whether exerts this effect when taken as one of the dietary components. In present study, we investigated two cultivars rice, low glutelin content (LGC)-1 and LGC-Jun, on reducing cholesterol exogenously hypercholesterolemic (ExHC) LGC-1 enriched (10.6 mg g-1 rice flour, which an approximately 1.5 times higher than Koshihikari a predominant cultivar Japan), whereas LGC-Jun...
Abstract Diabetes mellitus is a metabolic disease spreading worldwide that has been reported to worsen the development and progression of other diseases (cancer, vascular dementia). To establish functional rice lines with anti-postprandial hyperglycaemic effects, we developed mutant lines, which lack one or two gene(s) related starch synthesis, evaluated their effects. Powder grains was loaded rats fasted overnight (oral grain powder loading test). Incremental area under time-concentration...
Exogenously hypercholesterolemic (ExHC) rats develop diet-induced hypercholesterolemia (DIHC) when fed with dietary cholesterol. Previously, we reported that, under the high-sucrose-diet-feeding condition, a loss-of-function mutation in Smek2 results low activity of fatty acid synthase (FAS) followed by shortage hepatic triacylglycerol content ExHC and onset DIHC. However, relationship between FAS dysfunction is still unclear. Here, focused on carbohydrate metabolism, which provides...
A dietary symbiotic supplement of okara, a by-product tofu manufacturing with Bacillus coagulans lilac-01 found to reduce secondary bile acid (BA) in rat study and cholic (CA), primary 12α-hydroxylated (12αOH) BA, induces lipid accumulation rats. In this study, we investigated whether supplementation synbiotic okara improves CA-induced hepatic accumulation. Male Wistar/ST rats (4 weeks old) were fed or without CA-supplementation combined the for 2 weeks. The CA diet increased triglycerides...
A diet supplemented with cholic acid (CA), the primary 12α-hydroxylated bile acid, can induce hepatic lipid accumulation in rats without obesity. This study examined effects of a CA-supplemented on blood pressure (BP). After acclimation, WKAH/HkmSlc (3 weeks old) were divided into two groups and fed control AIN-93-based or (0.5 g CA/kg) for 13 weeks. The CA increased systolic diastolic BP as well concentrations rats. No changes found sodium concentration. Urinary albumin concentration CA-fed...
Suppressor of mek1 (Dictyostelium) homolog 2 (Smek2), was identified as one the responsible genes for diet-induced hypercholesterolemia (DIHC) exogenously hypercholesterolemic (ExHC) rats. A deletion mutation in Smek2 leads to DIHC via impaired glycolysis livers ExHC The intracellular role remains obscure. We used microarrays investigate functions with and ExHC.BN-Dihc2BN congenic rats that harbor a non-pathological allele from Brown-Norway on an background. Microarray analysis revealed...
In our previous study, enterohepatic 12α-hydroxylated (12α) bile acid (BA) levels were found to be correlated with hepatic triacylglycerol concentration in rats fed high-fat (HF) diet. Since BA composition is diverse depending on animal species, we evaluated whether such a relationship applicable mice response an HF C57BL/6JJmsSLC (B6) male diet for 13 weeks and analyzed triacylglycerol, cholesterol, oxysterols, other metabolites the liver. The was determined liver, small intestinal...
Abstract Background Inbred strains are characterized by less genetic variation, which suggests usefulness of inbred for evaluations various parameters. In this study, experimental reproducibility in several parameters was compared between an outbred Wistar rat and King A Hokkaido (WKAH/HkmSlc) rat, the strain that is originated from rats. Methods Difference variations investigated body compositions liver functions such as weight, triglycerides (TG), cholesterol plasma alanine...
Exogenously hypercholesterolemic (ExHC) rats develop hypercholesterolemia and low hepatic triacylglycerol (TAG) levels when dietary cholesterol is loaded. The responsible gene Smek2 was identified via linkage analysis using the original strain Sprague–Dawley (SD) rats. In this study, we compared SD ExHC to investigate a relationship between TAG observed in Male 4-weeks-old were fed 1% diet for 1 week. Serum liver parameters analyzed. Gene expression enzyme activities related metabolism also...
We had previously found plant sterols deposited in the bodies of stroke-prone spontaneously hypertensive rats (SHRSP)/Sea and Wistar Kyoto (WKY)/NCrlCrlj that a missense mutation Abcg5 cDNA sequence coded for ATP-binding cassette transporter (ABC) G5. used SHRSP/Izm, WKY/NCrlCrlj, WKY/Izm present study to determine mechanisms sterol deposition body. Jcl:Wistar were as control strain. A diet containing 0.5% fed resulted body but not or rats. Only single non-synonymous nucleotide change,...
Deficit of oxygen and nutrients in the tumor microenvironment (TME) triggers abnormal angiogenesis that produces dysfunctional leaky blood vessels, which fail to adequately perfuse tissues. Resulting hypoxia, exacerbation metabolic disturbances, generation an immunosuppressive TME undermine efficacy anticancer therapies. Use carefully scheduled inhibitors has been suggested overcome these problems normalize TME. Here, we propose alternative agonist-based normalization approach using a...