A5022295207- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Welding Techniques and Residual Stresses
- Diet, Metabolism, and Disease
- Advanced machining processes and optimization
- Cholesterol and Lipid Metabolism
- EEG and Brain-Computer Interfaces
- Peroxisome Proliferator-Activated Receptors
- Engineering and Environmental Studies
- Pancreatitis Pathology and Treatment
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Iron Metabolism and Disorders
- Color perception and design
- Cassava research and cyanide
- Microbial Metabolites in Food Biotechnology
- Gut microbiota and health
- ECG Monitoring and Analysis
- Diet and metabolism studies
- Olfactory and Sensory Function Studies
- Non-Destructive Testing Techniques
- Advanced Welding Techniques Analysis
- Trace Elements in Health
- Epoxy Resin Curing Processes
- Cancer, Lipids, and Metabolism
Hokkaido University
2016-2025
Daikin (Japan)
2024
Kyoto University
1950-2024
Osaka Metropolitan University
2023
Oita University
1993-2020
Japan Society for the Promotion of Science
2017
Kyushu University
1993-2015
Tokyo University of Agriculture and Technology
1996-2013
Tokyo University of Agriculture
2002-2003
Mitsubishi Electric (Japan)
2002
We have developed two different models of tumor angiogenesis by human brain tumors: one being tube formation bovine aortic endothelial (BAE) cells cocultured with in vitro, and other vivo mice when are transplanted into the dorsal sac. investigated whether could be induced BAE type I collagen gel these were seven glioma cell lines. Four lines, which had high levels basic fibroblast growth factor (bFGF) mRNA, cells. The was blocked coadministration anti-bFGF antibody. In model system mice,...
Ingestion of a high-fat (HF) diet is known to enhance bile acid (BA) secretion, but precise information about the BA molecular species lacking, especially on conjugated BAs in enterohepatic circulation. As cholesterol precursor BAs, we analyzed alterations entire metabolic pathway response HF without addition and diet. Additionally, evaluated relationships between metabolism some disorders, such as plasma transaminase activities glucose intolerance induced by Acclimated WKAH/HkmSlc male rats...
High-fat diet (HFD)-induced obesity is a primary risk factor for serious health problems. Although much research has been performed at the genomic level, lipidomic studies were limited. In this study, we aim to obtain comprehensive profile of circulating plasma lipids, which are altered in rodent rat by untargeted liquid chromatography–mass spectrometry. Rats fed with HFD 8 weeks had increased body weight, liver and adipose tissue weight. The analysis results revealed that polyunsaturated...
A high-fat diet increases 12α-hydroxylated (12αOH) bile acid (BA) secretion in rats, and secondary BAs are responsible for the leaky gut. This study aimed to examine role of primary 12αOH gut barrier impairment rats using dietary cholic (CA) supplementation (0.5 g/kg diet). The CA increased concentrations small large intestine, accompanied by impairment. Based on luminal concentrations, ex vivo leakiness was determined. Deoxycholic permeability whereas taurocholic (TCA) ileal permeability,...
There is an increasing need to explore the mechanism of progression non-alcoholic fatty liver disease. Steroid metabolism closely linked hepatic steatosis and steroids are excreted as bile acids (BAs). Here, we demonstrated that feeding WKAH/HkmSlc inbred rats a diet supplemented with cholic acid (CA) at 0.5 g/kg for 13 weeks induced simple without obesity. Liver triglyceride cholesterol levels were increased accompanied by mild elevation aminotransferase activities. no signs inflammation,...
We investigated whether marginal iron-deficiency (MID) without anemia influences liver lipid accumulation in rats. Ingestion of a MID diet which the iron concentration was half AIN-93 formulation (iron-adequate, IA) for 3 weeks decreased anemia. then evaluated influence on combination with high-sucrose (HS) and confirmed that HS-MID successfully Additionally, significant increase triglyceride found, accompanied by upregulation hepatic fatty acid synthase expression rats fed compared to those...
Difructose anhydride III (DFAIII) is a prebiotic involved in the reduction of secondary bile acids (BAs). We investigated whether DFAIII modulates BA metabolism, including enterohepatic circulation, rats fed with diet supplemented cholic acid (CA), one 12α-hydroxylated BAs. After acclimation, were control or DFAIII. 2 weeks, each group was further divided into two groups and without CA supplementation at 0.5 g/kg diet. levels analyzed aortic portal plasma, liver, intestinal content, feces....
We constructed a near infrared spectroscopy-based real-time feedback system to estimate the subjects' emotional states using changes in oxygenated hemoglobin concentration [Δ(oxy-Hb)] prefrontal cortex (PFC). Using this system, we investigated influences of continual mild and equivocal stimuli consisting lights reconstructed waterfall sound on Δ[oxy-Hb] PFC. The visual (light) auditory (sound) changed randomly independently, depending individual subjects. induced by were examined via...
There are numerous reports of enhanced or emerged visual arts abilities in patients with semantic impairment. These led to the theory that a loss function on language side brain can result changes ability draw and/or paint. Further, left posterior middle temporal gyrus (l-pMTG) has been revealed contribute higher control mechanisms objects recognition and integration information, within widely distributed network hemisphere. Nevertheless, not fully studied neural bases. The aim this study is...
Thiocyanate hydrolase (SCNase) is a cobalt-containing enzyme with post-translationally modified cysteine ligand, gammaCys131-SO(2)H. When the SCNase alpha, beta and gamma subunits were expressed in Escherichia coli, assembled to form hetero-dodecamer, (alphabetagamma)(4), like native but exhibited no catalytic activity. Metal analysis indicated that was as an apo-form irrespective of presence cobalt medium. On contrary, co-expressed P15K, encoded just downstream genes, cobalt-enriched medium...
Previously, we found a significant relationship in rat study between energy intake and bile acid (BA) metabolism especially 12α-hydroxylated (12αOH) BAs. The present was designed to reveal relationships among BA metabolism, glucose tolerance, cecal organic acids rats fed high-fat high-sucrose diet (HFS) by using multivariate multiple regression analyses two types of tolerance tests (GTTs).Male WKAH/HkmSlc were with control or HFS for 13 weeks. Oral test (OGTT) intraperitoneal (IPGTT)...
Abstract We previously reported that dietary supplementation with cholic acid (CA), the primary 12α-hydroxylated (12αOH) bile (BA), reduces plasma adiponectin concentration in rats. The aim of this study was to examine distribution body CA-fed rats and its influence on mucosal immunoglobulin A intestine. Rats were fed a diet supplemented or without CA (0.5 g CA/kg diet) for 13 weeks. reduction level observed from week 3. At end experiment, reduced both portal aortic plasma. Accumulation...
In our previous study, enterohepatic 12α-hydroxylated (12α) bile acid (BA) levels were found to be correlated with hepatic triacylglycerol concentration in rats fed high-fat (HF) diet. Since BA composition is diverse depending on animal species, we evaluated whether such a relationship applicable mice response an HF C57BL/6JJmsSLC (B6) male diet for 13 weeks and analyzed triacylglycerol, cholesterol, oxysterols, other metabolites the liver. The was determined liver, small intestinal...
A dietary symbiotic supplement of okara, a by-product tofu manufacturing with Bacillus coagulans lilac-01 found to reduce secondary bile acid (BA) in rat study and cholic (CA), primary 12α-hydroxylated (12αOH) BA, induces lipid accumulation rats. In this study, we investigated whether supplementation synbiotic okara improves CA-induced hepatic accumulation. Male Wistar/ST rats (4 weeks old) were fed or without CA-supplementation combined the for 2 weeks. The CA diet increased triglycerides...
A diet supplemented with cholic acid (CA), the primary 12α-hydroxylated bile acid, can induce hepatic lipid accumulation in rats without obesity. This study examined effects of a CA-supplemented on blood pressure (BP). After acclimation, WKAH/HkmSlc (3 weeks old) were divided into two groups and fed control AIN-93-based or (0.5 g CA/kg) for 13 weeks. The CA increased systolic diastolic BP as well concentrations rats. No changes found sodium concentration. Urinary albumin concentration CA-fed...
Abstract Background Inbred strains are characterized by less genetic variation, which suggests usefulness of inbred for evaluations various parameters. In this study, experimental reproducibility in several parameters was compared between an outbred Wistar rat and King A Hokkaido (WKAH/HkmSlc) rat, the strain that is originated from rats. Methods Difference variations investigated body compositions liver functions such as weight, triglycerides (TG), cholesterol plasma alanine...
Most traditional studies regarding arrhythmia detection using electrocardiogram (ECG) have proposed general methods applicable to various patients.Because patients their own unique ECG patterns, abnormalities undetected by can be detected if a new method tailored each patient is developed.Furthermore, the effectively support doctors in diagnosis it provide basis for determining abnormalities.Herein, we propose an individualized abnormality judgment autoencoder and convolutional neural...