A5011015630- Titanium Alloys Microstructure and Properties
- Intermetallics and Advanced Alloy Properties
- Endoplasmic Reticulum Stress and Disease
- Metal and Thin Film Mechanics
- Metallurgy and Material Forming
- Liver Disease Diagnosis and Treatment
- Advanced materials and composites
- Epoxy Resin Curing Processes
- Healthcare and Venom Research
- Advanced Polymer Synthesis and Characterization
- Carbon Dioxide Capture Technologies
- Sirtuins and Resveratrol in Medicine
- Photopolymerization techniques and applications
- Additive Manufacturing Materials and Processes
- Cell Adhesion Molecules Research
- Alzheimer's disease research and treatments
- Carbon Nanotubes in Composites
- PARP inhibition in cancer therapy
- Microstructure and Mechanical Properties of Steels
- Metal Alloys Wear and Properties
- Polymer composites and self-healing
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- High Temperature Alloys and Creep
- Neuroendocrine Tumor Research Advances
Sunchon National University
2017-2025
St. Jude Children's Research Hospital
2020-2025
Leon Wiltse Memorial Hospital
2013-2025
Chungbuk National University
2010-2024
Hokkaido University
2019-2023
Sungkyunkwan University
2022
Korea University
2014-2020
Ajou University
2020
Chonbuk National University Hospital
2012-2016
Korea Institute of Materials Science
2009-2016
Murine models of Alzheimer's disease (AD) are crucial for elucidating mechanisms but have limitations in fully representing AD molecular complexities. Here we present the comprehensive, age-dependent brain proteome and phosphoproteome across multiple mouse amyloidosis. We identified shared pathways by integrating with human metadata prioritized components multi-omics analysis. Collectively, two commonly used (5xFAD APP-KI) replicate 30% protein alterations; additional genetic incorporation...
SIRT1 (silent mating-type information regulation 2 homologue 1) expression has been reported to predict poor survival in some cancers. We therefore investigated the levels of and its negative regulator, DBC1 (deleted breast cancer 1), gastric patients.We evaluated immunohistochemical DBC1, SIRT1, p53 using 3-mm tumor cores from 177 patients for tissue microarray.Positive expressions were seen 62% (109 177) 73% (130 patients, respectively. Expression was significantly correlated with stage (P...
Stress that impairs endoplasmic reticulum (ER) function leads to an accumulation of unfolded or misfolded proteins in the ER (ER stress) and triggers protein response (UPR). Recent studies suggest stress is involved idiopathic pulmonary fibrosis (IPF). The present study was undertaken determine role on myofibroblastic differentiation fibroblasts. Fibroblasts fibroblastic foci IPF showed immunoreactivity for GRP78. To α-smooth muscle actin (α-SMA) collagen type I expression fibroblasts, mouse...
BACKGROUND: Clear cell renal carcinoma (CRCC) is the most common malignant tumor of kidney, and clinical outcome CRCC related with metastatic potential CRCC. A significant proportion remains incurable. Recently, immunotherapy against specific targets such as programmed death 1 (PD1) has been adapted for fatal cases MATERIALS AND METHODS: In this study, we aimed to evaluate tumor-infiltrating PD1-positive lymphocytes or FoxP3-positive regulatory T cells (Tregs) predictors prognosis...
Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, it suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma. Therefore, we investigated prevalence and prognostic impact expression diffuse large B-cell lymphoma (DLBCL). Immunohistochemical SIRT1, p53, bcl2, CD10, bcl6, multiple myeloma-1 (MUM1) were evaluated by using 2 mm core from 104 DLBCL patients for tissue microarray. Positive was seen 74% (77/104)...
In Brief Successful rhinoplasty depends on nasal tip support and its influence projection. It is generally agreed that the components of include attachment between upper lower lateral cartilages, crus cartilage pyriform aperture, paired domes medial crural to caudal septum. However, these structures are still not clearly determined, there was no anatomic study supporting in Asia. The purpose this determine find out differences white Asian people. Ten noses fresh cadavers were investigated....
The purpose of this pilot study was to compare proliferation, collagen synthesis, and growth factor production, which are important contributing factors for wound healing, the bone marrow stromal cells (BSCs) with those dermal fibroblasts in vitro. Cultured human BSCs from same patients were seeded 96-well culture plates. At 1, 3, 5 days postincubating, cell secretion basic fibroblast (bFGF), vascular endothelial (VEGF), transforming beta (TFG-beta) compared. We did not observe great...
Abstract Stress that impairs endoplasmic reticulum (ER) function leads to an accumulation of unfolded or misfolded proteins in the ER (ER stress). Autophagy is a lysosomal pathway involved turnover cellular macromolecules and organelles, which emerging data indicate stress also potent inducer autophagy. autophagy are human cancer. We examined expression stress‐related [GRP78 C/EBP homologous protein (CHOP)] autophagic (Beclin‐1 LC3) non‐small cell lung carcinomas (NSCLCs), bronchioloalveolar...
A retrospective cohort study.New vertebral compression fracture (NVCF) is a highly potential risk after percutaneous vertebroplasty (PVP). The study aimed at analyzing the incidence and factors of NVCF preventing its development.PVP widely used effective technique for reducing pain caused by an osteoporotic fracture. However, there great deal debate about whether PVP associated with NVCF, many have been hypothesized.From January to December 2008, total 198 patients (176 women, 22 men; mean...
Ingestion of a high-fat (HF) diet is known to enhance bile acid (BA) secretion, but precise information about the BA molecular species lacking, especially on conjugated BAs in enterohepatic circulation. As cholesterol precursor BAs, we analyzed alterations entire metabolic pathway response HF without addition and diet. Additionally, evaluated relationships between metabolism some disorders, such as plasma transaminase activities glucose intolerance induced by Acclimated WKAH/HkmSlc male rats...
Tandem mass tag (TMT) spectrometry is a mainstream isobaric chemical labeling strategy for profiling proteomes. Here we present 29-plex TMT method to combine the 11-plex and 18-plex strategies. The was examined with pooled sample composed of 1×, 3×, 10× Escherichia coli peptides 100× human background peptides, which generated two E. datasets (TMT11 TMT18), displaying distorted ratios 1.0:1.7:4.2 1.0:1.8:4.9, respectively. This ratio compression from expected 1:3:10 caused by co-isolated...
Purpose The success of basic molecular research using biospecimens strongly depends on the quality specimen. In this study, we evaluated effects delayed freezing time stability DNA and RNA in fresh frozen tissue from patients with colorectal cancer. Methods Tissues were at 10, 30, 60, 90 minutes after extirpation cancer 20 cases. Absorbance ratio 260 to 280 nm (A260/A280) agarose gel electrophoresis evaluated. addition, integrity number (RIN) was assayed for analysis integrity. Results...