A5043414368- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Homelessness and Social Issues
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Family and Disability Support Research
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Infant Development and Preterm Care
- Pancreatitis Pathology and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cannabis and Cannabinoid Research
- Food Security and Health in Diverse Populations
- Autism Spectrum Disorder Research
- Pharmacological Effects and Toxicity Studies
- Hepatitis B Virus Studies
- Sex work and related issues
- Alcohol Consumption and Health Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic and Hepatic Oncology Research
- Patient Safety and Medication Errors
Boston University
2016-2025
Massachusetts Department of Public Health
2021
Boston Medical Center
2017-2018
The Coordinating Center
2017
Beth Israel Deaconess Medical Center
2017
University of California, San Francisco
2016
Studies have demonstrated an association between anti-TNF/immunomodulator agents used in inflammatory bowel disease (IBD) and impaired hepatitis B virus (HBV) vaccine immunogenicity, but little data exist on whether specific medication types affect protective HBsAb titers. Our aim was to analyze this association. This is a retrospective cohort study. Inclusion criteria: age ≥18, diagnosis of Crohn's (CD) or ulcerative colitis (UC), previous HBV vaccination series and/or ≥1 positive HBsAb,...
<h3>Importance</h3> Early identification of autism spectrum disorder (ASD) is associated with improved cognitive and behavioral outcomes. Targeted strategies are needed to support equitable access diagnostic services ensure that children from low-income racial/ethnic minority families receive the benefits early ASD treatment. <h3>Objective</h3> To test efficacy family navigation (FN), an individually tailored, culturally informed care management strategy, increase likelihood achieving...
Venous thromboembolism after abdominal surgery occurs in 2% to 3% of patients with Crohn's disease and ulcerative colitis. However, no evidence-based guidelines currently exist guide postdischarge prophylactic anticoagulation.We sought determine the use postoperative venous chemical prophylaxis, 90-day rates, factors associated thromboembolic events IBD following surgery.This was a retrospective evaluation an administrative database.Data were obtained from Optum Labs Data Warehouse, large...
People living with HIV (PLWH) on antiretroviral therapy (ART) who use substances were examined to (a) describe those virologic control and (b) determine which substance use-factors are associated lack of control. Participants adult PLWH taking ART either past 12-month DSM-IV dependence or 30-day alcohol illicit drug use. Substance factors included number criteria specific Associations viral load (HVL) (<200 vs. ≥200 copies/mL) tested using logistic regression models. Multivariable analyses...
Background: Cigarette smoking has been associated with liver fibrosis in the setting of hepatitis C virus (HCV) infection but not studied among people HIV (PWH) who consume alcohol. Methods: This is a cross-sectional study PWH heavy drinking and daily St. Petersburg, Russia. The primary independent variable was past 30-day cigarettes per day (cpd), secondary pack-years at entry. Advanced defined as FIB-4 > 3.25. Analyses were adjusted for gender, body mass index (BMI), number days, HCV...
Low-income and minority mothers experience a disproportionate incidence of depression lack access to treatment services. Development prevention strategies in accessible community-based venues is potentially important public health strategy.To determine the efficacy strategy embedded Head Start.This randomized clinical trial was performed from February 15, 2011, through May 9, 2016, at 6 Start agencies serving families or below federal poverty level. Participants included with depressed mood,...
Cigarette smoking and risky alcohol consumption co-occur are undertreated. Nicotine receptor partial agonists nicotine replacement therapy (NRT) treat but unproven for alcohol, clinical trials rarely include individuals with HIV, substance use, mental health conditions.
Of the 12 million people who inject drugs worldwide, 13% live with HIV. Whether opioid use impacts HIV pathogenesis and latency is an outstanding question. To gain insight into whether influences proviral landscape latent reservoir, we performed intact DNA assays (IPDA) on peripheral blood mononuclear cells (PBMCs) from antiretroviral therapy (ART)-suppressed living (PWH) or without current use. No differences were observed between PWH in frequency of defective genomes. evaluate activated...
Although people with HIV infection (PLWH) are at higher risk of polypharmacy and substance use, there is limited knowledge about potential harms associated such as falls fractures in this population. The study objective was to determine whether polypharmacy, measured by the number type medication, among PLWH DSM-IV dependence past year or ever injection drug use (IDU). We identified medications electronic medical record review following categories: (i) systemically active, (ii)...
Background Biomarkers of monocyte activation (soluble CD14 [sCD14]), inflammation (interleukin-6 [IL-6]), and altered coagulation (D-dimer) are associated with increased mortality risk in people HIV. The objective the Russia Alcohol Research Collaboration on HIV/AIDS (ARCH) study was to evaluate association between heavy alcohol use inflammatory biomarkers over time. Methods sought antiretroviral therapy naive participants HIV (n = 350) assessed them at baseline, 12 24 months. Linear mixed...
Reasons for resident underutilization of adverse event (AE) reporting systems are unclear, particularly given frequent exposure to AEs and near misses (NMs). Residents at an academic medical center were surveyed about AEs/NMs, barriers reporting, patient safety climate, educational interventions. A total 350 527 eligible residents (66%) completed the survey; 77% respondents reported involvement in AE/NM, though only 43% had used system. Top not knowing what or how report. Surgeons more than...
Background People living with HIV ( PLWH ) commonly have low bone mineral density BMD (low mass and osteoporosis) are at high risk for fractures. Fractures significant causes of morbidity mortality, increasingly relevant as age. Alcohol use is common among known to affect health. The association between alcohol changes in not well understood. Methods We conducted a 3.5‐year prospective cohort study 250 substance disorder or ever injection drug use. Annual consumption was measured mean grams...
HIV-positive people who inject drugs (PWID) are stigmatized and face more challenges in accessing ART. The natural course of stigma its role on ART initiation this population is unclear. We examined 1] whether HIV changes over time 2] substance use associated with a prospective cohort PWID St. Petersburg, Russia.We used data from 165 were ART-naïve at enrollment andgeneralized estimating equations to assess between baseline, 12- 24-month study visits. Logistic regression estimated...
Low bone mineral density (BMD) is common in people living with HIV infection (PLWH), increasing fracture risk. Alcohol use also PLWH and a modifiable risk factor for both disease progression low BMD. In PLWH, alcohol's effect on BMD not well understood. We studied adult substance dependence. measured lifetime alcohol (kg) recent (i.e., past 30-day) (categorized as: abstinent, risk, or high risk). adjusted multivariable regression analyses, we tested associations between (i) mean (g/cm2) at...
Abstract Background The multifactorial mechanisms driving negative health outcomes among risky drinkers with HIV may include immunosenescence. Immunosenescence, aging of the immune system, be accentuated in and leads to poor outcomes. liver regulates innate immunity adaptive tolerance. HIV-infected people have high prevalence liver-related comorbidities. We hypothesize that advanced fibrosis/cirrhosis is associated alterations T-cell subsets consistent Methods ART-naïve a recent history...
Objective: The authors sought to determine whether a multicomponent, community-based program for preventing maternal depression also promotes engagement with mental health services individuals persistent symptoms. Methods: Mothers of children enrolled in Head Start were randomly assigned between February 2011 and May 2016 Problem-Solving Education (PSE) (N=111) or usual (N=119) assessed every two months 12 months. Results: Among 230 participants, 66% Hispanic; 223 participants included the...