A5035462021- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- HIV-related health complications and treatments
- Homelessness and Social Issues
- Cannabis and Cannabinoid Research
- Sex work and related issues
- HIV/AIDS drug development and treatment
- Food Security and Health in Diverse Populations
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Substance Abuse Treatment and Outcomes
- Smoking Behavior and Cessation
- Pneumocystis jirovecii pneumonia detection and treatment
- Opioid Use Disorder Treatment
- Adolescent Sexual and Reproductive Health
- Pharmacological Effects and Toxicity Studies
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Pharmacological Receptor Mechanisms and Effects
- Global Public Health Policies and Epidemiology
- Reproductive Health and Contraception
- Cancer, Stress, Anesthesia, and Immune Response
- HIV, TB, and STIs Epidemiology
- Sexuality, Behavior, and Technology
Boston Medical Center
2016-2025
Boston University
2013-2024
University of California, Los Angeles
2020
Background: Cigarette smoking has been associated with liver fibrosis in the setting of hepatitis C virus (HCV) infection but not studied among people HIV (PWH) who consume alcohol. Methods: This is a cross-sectional study PWH heavy drinking and daily St. Petersburg, Russia. The primary independent variable was past 30-day cigarettes per day (cpd), secondary pack-years at entry. Advanced defined as FIB-4 > 3.25. Analyses were adjusted for gender, body mass index (BMI), number days, HCV...
<h3>Importance</h3> Zinc supplementation can reduce alcohol-related microbial translocation and inflammation. <h3>Objective</h3> To assess whether zinc reduces markers of mortality risk cardiovascular disease, levels inflammation translocation, slows HIV disease progression in people with heavy alcohol use who are living HIV/AIDS. <h3>Design, Setting, Participants</h3> This study is a double-blinded placebo-controlled randomized clinical trial among participants recruited from 2013 to 2015....
Cigarette smoking and risky alcohol consumption co-occur are undertreated. Nicotine receptor partial agonists nicotine replacement therapy (NRT) treat but unproven for alcohol, clinical trials rarely include individuals with HIV, substance use, mental health conditions.
Of the 12 million people who inject drugs worldwide, 13% live with HIV. Whether opioid use impacts HIV pathogenesis and latency is an outstanding question. To gain insight into whether influences proviral landscape latent reservoir, we performed intact DNA assays (IPDA) on peripheral blood mononuclear cells (PBMCs) from antiretroviral therapy (ART)-suppressed living (PWH) or without current use. No differences were observed between PWH in frequency of defective genomes. evaluate activated...
In the Russian Federation (Russia), an elevated burden of premature mortality attributable to non-communicable diseases (NCDs) has been observed since country's economic transition. NCDs are largely related preventable risk factors such as unhealthy diets.
Background Biomarkers of monocyte activation (soluble CD14 [sCD14]), inflammation (interleukin-6 [IL-6]), and altered coagulation (D-dimer) are associated with increased mortality risk in people HIV. The objective the Russia Alcohol Research Collaboration on HIV/AIDS (ARCH) study was to evaluate association between heavy alcohol use inflammatory biomarkers over time. Methods sought antiretroviral therapy naive participants HIV (n = 350) assessed them at baseline, 12 24 months. Linear mixed...
Objective: To determine whether the Linking Infectious and Narcology Care strengths-based case management intervention was more effective than usual care for linking people who inject drugs (PWID) to HIV improving outcomes. Design: Two-armed randomized controlled trial. Setting: Participants recruited from a narcology hospital in St. Petersburg, Russia. Participants: A total of 349 HIV-positive PWID not on antiretroviral therapy (ART). Intervention: Strengths-based over 6 months. Main...
The human immunodeficiency virus (HIV) epidemic in Russia, driven by injection drug use, has seen a steady rise the past two decades. Hepatitis C (HCV) infection is highly prevalent people who inject drugs (PWID). study aimed to describe current frequency of HCV testing and treatment among HIV-infected PWID St. Petersburg, Russia. This examined baseline data from "Linking Infectious Narcology Care" (LINC) "Russia Alcohol Research Collaboration on HIV/AIDS" (Russia ARCH) studies. Participants...
Background and aims Liver disease in people living with HIV co-infected hepatitis C virus is a source of morbidity mortality Russia. accelerates liver fibrosis the setting HCV co-infection alcohol use. Zinc deficiency common among may be factor that facilitates underlying mechanisms fibrosis. We investigated association between zinc advanced cohort HIV/HCV persons reporting heavy drinking Methods This secondary data analysis baseline from 204 anti-retroviral treatment naïve Russians were...
Engaging people who drink alcohol or inject drugs in HIV care can be challenging, particularly Eastern Europe. Healthcare facilities Russia are organized by specialty; therefore linking patients from addiction to hospitals has been difficult. The cascade outlines stages of (e.g., linkage care, prescribed antiretroviral therapy [ART], and achieving viral suppression). We hypothesized that unhealthy use, injection drug opioid craving associated with unfavorable outcomes. analyzed data a cohort...
Background Russia continues to have an uncontrolled HIV epidemic and its per capita alcohol consumption is among the highest in world. Alcohol use HIV-positive individuals common associated with worse clinical outcomes. each lead microbial translocation, which turn results inflammation. Zinc supplementation holds potential for lowering levels of biomarkers inflammation, possibly as a consequence impact on intestinal permeability. This paper describes protocol double-blinded randomized...
Russia and Eastern Europe have one of the fastest growing HIV epidemics in world. While countries this region implemented testing within addiction treatment systems, linkage to care from these settings is not yet standard practice. The Linking Infectious Narcology Care (LINC) intervention utilized peer-led strengths-based case management motivate HIV-infected patients obtain care. This paper describes protocol a randomized controlled trial evaluating effectiveness LINC St. Petersburg,...
HIV-positive people who inject drugs (PWID) are stigmatized and face more challenges in accessing ART. The natural course of stigma its role on ART initiation this population is unclear. We examined 1] whether HIV changes over time 2] substance use associated with a prospective cohort PWID St. Petersburg, Russia.We used data from 165 were ART-naïve at enrollment andgeneralized estimating equations to assess between baseline, 12- 24-month study visits. Logistic regression estimated...
To estimate the effects on pain of two medications (low-dose naltrexone and gabapentin) compared to placebo among people with HIV (PWH) heavy alcohol use chronic pain.
Abstract Background The multifactorial mechanisms driving negative health outcomes among risky drinkers with HIV may include immunosenescence. Immunosenescence, aging of the immune system, be accentuated in and leads to poor outcomes. liver regulates innate immunity adaptive tolerance. HIV-infected people have high prevalence liver-related comorbidities. We hypothesize that advanced fibrosis/cirrhosis is associated alterations T-cell subsets consistent Methods ART-naïve a recent history...
Abstract Background Alcohol use has been linked to worse human immunodeficiency virus (HIV) immunologic/virologic outcomes, yet few studies have explored the effects of alcohol disorder (AUD). This study assessed whether AUD severity is associated with HIV viral suppression and CD4 count in three cohorts Uganda Russia Boston Network for Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium. Methods People (PWH) ( n = 301), 400), 251), selected in‐part based their use, were included...
Abstract Background and aim In 2018, the country of Georgia legalized cannabis for recreational use decriminalized limited possession. This study aimed to assess whether increased among young adults (ages 18–29 years) in after national policy changes evaluate perceived access became easier legalization current risk factors adult use. Methods We used data from Georgian nationally representative survey administered 2015 ( n = 1308) 2022 758), before decriminalization. performed appropriate...
HIV, heavy drinking, and smoking are all pro-inflammatory increase risk for coronary heart disease (CHD). Interventions that reduce alcohol use, smoking, or both in HIV-positive people could lower inflammation, CHD death risk. Varenicline cytisine proven therapies cessation may also consumption. The comparative efficacy of varenicline to consumption has not been tested, nor their effectiveness reported smoking.This paper describes the protocol Studying Partial agonists Ethanol Tobacco...