A5073183425- Pneumonia and Respiratory Infections
- COVID-19 Impact on Reproduction
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Reproductive System and Pregnancy
- Bacterial Infections and Vaccines
- Pregnancy and Medication Impact
- Ear Surgery and Otitis Media
- Gestational Diabetes Research and Management
- Hepatitis C virus research
- Streptococcal Infections and Treatments
- Pregnancy and preeclampsia studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- HIV/AIDS Research and Interventions
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Lipid Membrane Structure and Behavior
- Voice and Speech Disorders
- Advanced Drug Delivery Systems
- NF-κB Signaling Pathways
- Microbial infections and disease research
- Advancements in Transdermal Drug Delivery
Boston Medical Center
2013-2024
Boston University
2011-2024
Office of the Director
2024
University of Utah
2024
Duke University
2024
University of North Carolina at Chapel Hill
2024
University of Alabama at Birmingham
2024
MetroHealth Medical Center
2024
The Ohio State University
2024
Ohio University
2024
The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel blood proteome. Although thought be involved immune defense, net biological effect of remains unknown. As stimulated by diverse cytokines that activate either NF-κB or STAT3, we hypothesized it could eliminated hepatocyte-specific interruption both transcription factors. Here, report elimination mice p65 (RelA) and but neither alone, abrogated all responses measured....
A hydrogel drug delivery system allowed controlled, local of ciprofloxacin across the tympanic membrane to treat acute otitis media in chinchillas.
Glecaprevir/pibrentasvir (GLE/PIB) has shown high efficacy and safety in chronic HCV-infected adults adolescents; data children were limited. DORA part 2 is a phase 2/3, nonrandomized, open-label study evaluating the pharmacokinetics, efficacy, of pediatric formulation GLE PIB ages 3 to < 12 years.Children with HCV infection, genotype 1-6, or without compensated cirrhosis, divided into three cohorts by age-cohort (9 years), cohort (6 9 4 (3 6 years)-and given weight-based doses for 8, 12, 16...
OBJECTIVE: To estimate the rate of perinatal transmission hepatitis C virus (HCV) infection, to identify risk factors for HCV and determine viremic threshold transmission. METHODS: This was a prospective, multicenter, observational study pregnant individuals at less than 24 weeks gestation screened infection from 2012 2018 in Eunice Kennedy Shriver National Institute Child Health Human Development Maternal-Fetal Medicine Units Network. Individuals found be antibody–positive were followed...
Our objective was to develop a prediction model for hepatitis C virus (HCV) infection perinatal transmission improve triage neonatal follow-up. This secondary analysis of HCV antibody–positive participants who were enrolled in the Eunice Kennedy Shriver National Institute Child Health and Human Development Maternal-Fetal Medicine Units Network multicenter observational study pregnancy. Among 432 participants, rate 6.0% (95% CI, 4.0–8.7%). The developed included two factors: maternal RNA...
Otits media (OM) is the most frequent indication for antimicrobial prescription to US children. Streptococcus pneumoniae (S. pneumoniae) remains one of common pathogens causing OM. Successful eradication S. in middle ear can be achieved by adhering a 7–10 day regimen oral antibiotics. However, drug administration challenging parents. Lack adherence has been associated with treatment failure or early relapse. To overcome this challenge, we used noninvasive formulation achieve high...
ABSTRACT Strategies to limit complement deposition on Streptococcus pneumoniae are established as virulence features for invasive disease, but their role in respiratory tract infection requires further analysis. We evaluated C3 protein discordant S. isolates of the same serotype (6A) and capacity cause nasopharyngeal (NP) colonization experimental otitis media (EOM) an animal model. compared binding five 6A from asymptomatic NP carriers with strains that caused we observed less (∼10-fold...
Coronavirus disease 2019 [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] infection at varying time points during the pregnancy can influence antibody levels after delivery. We aimed to examine SARS-CoV-2 IgG, IgM and IgA receptor binding domain of spike protein nucleocapsid (N-protein) reactive concentrations in maternal blood, infant blood breastmilk birth 6 weeks early versus late gestation.Mothers with were enrolled between July 2020 May 2021. Maternal breast milk samples...
OBJECTIVE: To characterize breastfeeding behaviors and identify factors associated with initiation among people hepatitis C virus (HCV) infection. METHODS: We conducted a secondary analysis of multicenter observational cohort pregnant singleton gestations HCV seropositivity. This includes individuals data on excludes those human immunodeficiency (HIV) co-infection. The primary outcome was self-reported or provision expressed breast milk. Secondary outcomes included duration breastfeeding....
Objective SARS-CoV-2 infection during pregnancy has been linked with an increased risk of hypertensive disorders (HDP). The aim this study was to examine how both trimester and severity impact HDP.
The pneumococcal Pilus-1 enhances attachment to epithelial cells in the respiratory tract and subsequent invasion. expression is bi-stable positively regulated by RlrA transcriptional regulator. To delineate role of pilus-1 Experimental Otitis Media (EOM), we evaluated colonization disease due a Streptococcus pneumoniae (SP) wild type strain (Taiwan19F-14 wt) its otherwise isogenic pilus-2 deficient mutant ΔPI-1/PI-2-) as well potential for chimeric protein (RrgB321) vaccine candidate...
Abstract COVID-19 disease has been a pandemic caused by β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A life-threatening multisystem inflammatory (MIS), secondary to SARS-CoV-2 virus infection, sharing common features with Kawasaki shock syndrome, staphylococcal/streptococcal and macrophage activation in pediatric patients described. total of 27 cases adults (MIS-A) similar presentation have reported so far. Here we describe the case 21-year-old man admitted...
Objective This study aimed to describe maternal characteristics and clinical outcomes of infants born mothers with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests during pregnancy at an urban, safety-net hospital in Boston. Study Design We abstracted electronic chart data from 75 pregnant women SARS-CoV-2 any stage gestation until 72 hours after birth who delivered consecutively between March 31 August 6, 2020 our center. collected on infant characteristics,...