A5063540692- Organ Transplantation Techniques and Outcomes
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Plant pathogens and resistance mechanisms
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Cerebral Venous Sinus Thrombosis
- Bioenergy crop production and management
- Biochemical Acid Research Studies
- Cassava research and cyanide
- Meningioma and schwannoma management
- Plant Genetic and Mutation Studies
- Science, Research, and Medicine
- Neurofibromatosis and Schwannoma Cases
- Photosynthetic Processes and Mechanisms
- Retinal Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Plant Disease Resistance and Genetics
- Cancer, Hypoxia, and Metabolism
- Plant and animal studies
- Acute Myeloid Leukemia Research
Taisho Pharmaceutical (Japan)
2025
Nihon University
2023
Kyoto University
2000-2023
KeyGene (Netherlands)
2022
Palmetto Hematology Oncology
2019
Tohoku University
2004-2007
Japanese Red Cross Society Wakayama Medical Center
2000-2001
Ludwig-Maximilians-Universität München
1998
Radish (Raphanus sativus L., n = 9) is one of the major vegetables in Asia. Since genomes Brassica and related species including radish underwent genome rearrangement, it quite difficult to perform functional analysis based on reported genomic sequence rapa. Therefore, we performed sequencing radish. Short reads sequences 191.1 Gb were obtained by next-generation (NGS) for a inbred line, 76,592 scaffolds ≥300 bp constructed along with bacterial artificial chromosome-end sequences. Finally,...
Ozoralizumab (OZR) is a next-generation anti-TNF NANOBODY® compound. The primary objective was to evaluate the efficacy of OZR in patients with rheumatoid arthritis (RA) varying factor (RF) and anti-citrullinated peptide antibody (ACPA) titres. secondary changes RF ACPA titres following treatment. A post hoc analysis conducted on data from Phase II/III OHZORA trial, which included 381 Japanese RA who were treated either 30 or 80 mg over 52 weeks after demonstrating an inadequate response...
Summary Brassica napus is an amphidiploid species with the A genome from rapa and C oleracea . Although B. , artificially synthesized amphidiploids AC are self‐incompatible, self‐compatible. Six S genotypes were identified in five of which had class I haplotypes one a II haplotype other species, mutations causing self‐compatibility three these genotypes. The most predominant genotype ( BnS‐1;BnS‐6 ), that cv. ‘Westar’, similar to S‐47 BrS‐47 ) S‐15 BoS‐15 ). stigmas ‘Westar’ rejected pollen...
Prokaryotes that can oxidize carbon monoxide (CO oxidizers) use this gas as a source of or energy. They with dehydrogenases (CODHs): these are divided into nickel-containing CODH (Ni-CODH), which sensitive to O2, and molybdenum-containing (Mo-CODH), function aerobically. The oxygen conditions required for CO oxidizers may be limited, those have been isolated characterized so far contain either Ni- Mo-CODH. Here, we report novel oxidizer, Parageobacillus sp. G301, is capable oxidation using...
In self-incompatibility, a number of S haplotypes are maintained by frequency-dependent selection, which results in trans-specific haplotypes. The region several kilobases (approximately 40-60 kb) from SP6 to SP2, including self-incompatibility-related genes and some adjacent Brassica rapa, has high nucleotide diversity due the hitchhiking effect, therefore we call this "S-locus complex." Recombination S-locus complex is considered be suppressed. We sequenced regions >50 kb three B. rapa...
Abstract The recognition specificity of the pollen ligand self-incompatibility (SP11/SCR) was investigated using Brassica rapa transgenic plants expressing SP11 transgenes, and Raphanus sativus S-21 found to have same as that B. S-9. In a set three S haplotypes, whose sequence identities SRK are fairly high, R. S-6 showed oleracea S-18 slightly different from S-52. S-18, however, Using these similar chimeric proteins were produced by domain swapping. Bioassay revealed incompatibility...
Nine eyeballs were enucleated from nine patients with excessive myopia, secondary retinochoroidal atrophy, absolute glaucoma, uveal malignant melanoma, Behçet's disease and sympathetic ophthalmia. The retina choroid studied light electron microscopes. results were: In marked blockade of choriocapillaries was accompanied by progressive retinal degeneration. atrophy induced retrobulbar fibrosis, the partially blocked had markedly degenerated. disease, exudative inflammation recognized in...
Brassica rapa is an important model crop in the genus Brassica, which includes various vegetable crops such as Chinese cabbage and turnip, closely related to Arabidopsis thaliana (Arabidopsis). B. var. trilocularis (yellow sarson), a rapid-cycling population of rapa, commonly used for genetic research expected bridge gap between plant crops. In this study, 940 M2 mutagenized lines yellow sarson were produced using ethylmethanesulfonate (EMS) mutagenesis, these plants examined alterations...
Browning of plant tissue is generally considered attributable to enzymatic oxidation by polyphenol oxidase (PPO). Electrophoresis followed activity staining has been used as an effective procedure visually detect and isolate isozymes; however, it not applied for examination various PPO isozymes in lettuce. Our study demonstrated that different lettuce could be detected at pH active staining, multiple were only under alkaline conditions. As a result, we concluded with approximately 8 enabled...
Although several intravital fluorescence microscopic studies demonstrated that microcirculatory derangement is induced during liver ischemia-reperfusion, these data were obtained from randomly selected microvascular areas and microvessels. Repeated observation of the identical microvessels has not been performed yet. Using a specially designed cover glass, it now possible to relocate desired sites repeatedly over whole reperfusion time. The aim this study was determine impact time on hepatic...
RNase H-dependent gapmer antisense oligonucleotides (ASOs) are a promising therapeutic approach via sequence-specific binding to and degrading target RNAs. However, the efficacy mechanism of antiviral ASOs have remained unclear. Here, we investigated inhibitory effects containing locked nucleic acids (LNA gapmers) on proliferating mosquito-borne flavivirus, Japanese encephalitis virus (JEV), with high mortality. We designed several LNA gapmers targeting 3' untranslated region JEV genomic In...
Background: GATA2 is the most frequently mutated gene in childhood AML. These patients have germline mutations one allele of and a high predisposition for MDS/AML. Also, mouse, Gata2 required embryonic HSC generation survival complete deletion lethal at day (E)10, while haploinsufficiency results severe reduction formation HSCs. The first HSCs are formed E10.5 through process called endothelial-to-hematopoietic transition (EHT) from specialized hemogenic endothelial cells dorsal aorta...
Abstract Prokaryotes, known as carbon monoxide (CO) oxidizers, use CO the or energy source with dehydrogenases (CODHs), which are divided into nickel-containing CODH (Ni-CODH) that sensitive to O 2 and molybdenum-containing (Mo-CODH) capable of aerobic functioning. The oxygen conditions for oxidizers oxidize may be limited because isolated characterized so far have either Ni- Mo-CODH. Here, we report a novel oxidizer oxidation both types based on genomic physiological characterization...