A5004616846- Breast Cancer Treatment Studies
- Phytochemistry Medicinal Plant Applications
- Vitamin C and Antioxidants Research
- Breast Lesions and Carcinomas
- Antioxidant Activity and Oxidative Stress
- Cardiac Ischemia and Reperfusion
- Coenzyme Q10 studies and effects
- Cancer Treatment and Pharmacology
- Natural product bioactivities and synthesis
- Cardiovascular Function and Risk Factors
- Skin Protection and Aging
- Hormonal and reproductive studies
- Sirtuins and Resveratrol in Medicine
- Allergic Rhinitis and Sensitization
- Natural Compounds in Disease Treatment
- Biochemical effects in animals
- Advanced Breast Cancer Therapies
- Pulmonary Hypertension Research and Treatments
- Chromatography in Natural Products
- Electrospun Nanofibers in Biomedical Applications
- Contact Dermatitis and Allergies
- Advances in Oncology and Radiotherapy
- Advanced Radiotherapy Techniques
- Salivary Gland Disorders and Functions
- Cardiovascular Issues in Pregnancy
Universidade Federal do Rio Grande do Sul
2016-2025
University of Perugia
2023
Universidade Federal do Rio Grande
2023
University of Florence
2016-2022
University of Pisa
1986-2021
Instituto de Ciências Farmacêuticas
2020
Azienda Ospedaliero-Universitaria Careggi
1994-2017
Procter & Gamble (Italy)
2017
University of Parma
2014
Istituto di Fisiologia Clinica
2011-2013
Oxidative stress arises from an imbalance between the production of free radicals and antioxidant defences. Several studies have suggested that dietary antioxidants (such as polyphenols berberine) may counteract oxidative through involvement Sirtuin 1/Adenosine Monophosphate-Activated Protein Kinase (SIRT1/AMPK) pathway. The aim this study was to evaluate direct specific activity some natural compounds, well their ability modulate expression SIRT1 activation AMPK. Quercetin, tyrosol, ferulic...
Achyrocline satureioides, popularly known as "marcela", is a medicinal plant found in South America. This rich flavonoids, which have been reported to exert numerous biological activities. The aim of this study was purify, identify and evaluate the mechanisms underlining anticancer activity A. satureioides flavonoids glioma cell lines (U87, U251 C6) well their comparative toxicity normal brain cells (primary astrocytes, neurons organotypic hippocampal cultures). main present are luteolin,...
The objective of this study was to explore the therapeutic effect blueberries on hematological parameters, oxidative stress, and interleukin-10 levels in acute hemolytic anemia induced by administration an intraperitoneal injection 40 mg/kg phenylhydrazine. Male Wistar rats were divided into three groups: Control, (PHZ), plus (PHZ+BB). Blueberries administered via oral gavage (250 mg/day). erythrocyte osmotic fragility, splenomegaly, iron metabolism, analysis, reactive oxygens species,...
Background/Objectives: Our group has been trying to bring scientific rationale the quality, safety and efficacy of Brazilian medicinal plants. This work was first step a broader project evaluating potential Monteverdia ilicifolia capsules for managing dyspepsia in randomized, double-blind clinical trial. M. is native species widely used traditional medicine treating gastric disturbances. The central aim present develop containing an standardized spray-dried extract (SDP) on lab scale...
Objective: To investigate whether the regular administration of blueberry extract and low-intensity resistance exercise training (RT), either alone or in combination, during development monocrotaline (MCT)-induced severe pulmonary arterial hypertension (PAH) rats protect left ventricle (LV) from redox dysregulation pathological remodeling. Methods: Groups seven male Wistar were formed for experiment: sedentary control; hypertensive; hypertensive blueberry; blueberry. PAH was experimentally...
To evaluate the prognostic significance of oxidative stress on rate major adverse cardiovascular events (MACEs: cardiac and all-cause death, nonfatal myocardial infarction, coronary revascularization-PTCA/CABG) in CAD.We studied 97 angiographically proven CAD patients (78 males, age: 67±11 years, mean± SD). Reactive oxygen metabolites total antioxidant status, assessed by commercially assays (d-ROMs OXY-Adsorbent Test; Diacron, Grosseto, GR, Italy), were used to calculate oxidant/antioxidant...
Background: Enhanced oxidative stress has been associated with atherosclerosis and coronary artery disease (CAD). However, the predictive value of circulating biomarkers for cardiovascular events (CE) in patients CAD remained poorly understood.
Abstract Background and Purpose In cor pulmonale , the increased afterload imposed on right ventricle (RV) generates a maladaptive response, impairing contractile cardiac function. Oxidative mechanisms play an important role in pathophysiology progression of this disease. The administration pterostilbene (PTS), phytophenol with antioxidant potential, may represent therapeutic option. present study, we evaluated effect PTS complexed hydroxypropyl‐β‐cyclodextrin (HPβCD) hypertrophy, function...
Polymers are often used to coat tablets for controlled drug release. The purpose of this study is evaluate the solubility HPMC and PVA blend compared isolated polymers in solutions with a pH biological fluids (6 1.2) dissolution capsules obtained using theophylline granules produced HPMC/PVA 25/75 as matrix coating. completely solubilized medium that simulates stomach intestine, polymer allows controlling medium, differents pH. time was monitored by UV absorbance maximum at 269 nm. released...
Oxidative stress alters signalling pathways for survival and cell death favouring the adverse remodelling of postmyocardial remnant cardiomyocytes, promoting functional impairment. The administration pterostilbene (PTS), a phytophenol with antioxidant potential, can promote cardioprotection represents therapeutic alternative in acute myocardial infarction (AMI). present study aims to explore effects oral PTS complexed hydroxypropyl-β-cyclodextrin HPβCD (PTS:HPβCD complex) on glutathione...
This study explored the effect of pterostilbene (PTS) complexed with hydroxypropyl-β-cyclodextrin (HPβCD) on right heart function, glutathione and glutaredoxin systems, expression redox-sensitive proteins involved regulation calcium levels in experimental model pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). After 7 days PAH induction, rats received daily doses PTS:HPβCD complex (corresponding to 25, 50, or 100 mg·kg −1 PTS) vehicle (control group, CTR0) (an aqueous...
ABSTRACT The Patient and Observer Scar Assessment Scale ( POSAS ) is one of the most robust instruments to assess scar quality, but there no Italian version, other competing are available in Italian. aim this study was translate validate an version ‐I). POSASv2 .0 culturally adapted accordance with international standards. psychometric assessment included acceptability/feasibility, internal consistency, reproducibility, construct validity sensitivity change. Cultural equivalence ‐I English...
Abstract Introduction Phenolic compounds present in Achyrocline satureioides are known to have therapeutic benefits like antioxidant, anti‐inflammatory, and antitumour properties. The main polyphenols the plant quercetin (QCT), luteolin (LUT), 3‐ O ‐methylquercetin (3 MQ), achyrobichalcone (ACB). However, effective isolation purification of these from A. inflorescences not an easy task. Objective To develop efficient high‐performance counter‐current chromatography (HPCCC) method for quick...
Background: Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. Materials & methods: Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 5 kg/m2) and 306 over- normal-weight subjects (112 194 24 3 kg/m2). Results: d-ROMs levels higher than (395 104 vs 362 102 351 84 arbitrary units (AU); p < 0.001), women males (390 327 68 AU; with those without...