A5023193135- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cannabis and Cannabinoid Research
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Mitochondrial Function and Pathology
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Cardiovascular Effects of Exercise
- Chemotherapy-induced cardiotoxicity and mitigation
- Amino Acid Enzymes and Metabolism
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Biochemical effects in animals
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac electrophysiology and arrhythmias
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
- Transplantation: Methods and Outcomes
- Signaling Pathways in Disease
- Biochemical Acid Research Studies
- Advanced battery technologies research
- Extracellular vesicles in disease
- Pharmacogenetics and Drug Metabolism
- Nicotinic Acetylcholine Receptors Study
Brown University
2022-2025
Lifespan
2024-2025
Rhode Island Hospital
2024-2025
Providence VA Medical Center
2022-2024
Universidade Federal do Rio Grande do Sul
2000-2023
St. Boniface Hospital
2018
University of Manitoba
2018
Life & Brain (Germany)
2012-2015
University of Bonn
2010-2015
Vanderbilt University
2014
Reduced exercise capacity in pulmonary hypertension (PH) significantly impacts quality of life. However, the cause reduced PH remains unclear. The objective this study was to investigate whether intrinsic skeletal muscle changes are causative using preclinical rat models with different severity. induced adult Sprague-Dawley (SD) or Fischer (CDF) rats one dose SU5416 (20 mg/kg) injection, followed by 3 weeks hypoxia and additional 0-4 normoxia exposure. Control s were injected vehicle housed...
ABSTRACT Pulmonary vascular disease is not a single condition; rather it can accompany variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat increasingly possible with growing accessibility powerful clinical research tools. Nevertheless, challenges exist in implementing these tools optimal effect. The 2023 Grover Conference Series reviewed landscape summarize current state art provide...
Oxidative stress alters signalling pathways for survival and cell death favouring the adverse remodelling of postmyocardial remnant cardiomyocytes, promoting functional impairment. The administration pterostilbene (PTS), a phytophenol with antioxidant potential, can promote cardioprotection represents therapeutic alternative in acute myocardial infarction (AMI). present study aims to explore effects oral PTS complexed hydroxypropyl-β-cyclodextrin HPβCD (PTS:HPβCD complex) on glutathione...
Abstract Pulmonary hypertension (PH) results in RV hypertrophy, fibrosis and dysfunction resulting failure which is associated with impaired metabolism mitochondrial respiration. Mitochondrial supercomplexes (mSC) are assemblies of multiple electron transport chain (ETC) complexes that consist physically complex I, III IV may enhance respiration lower ROS generation. The goal this study was to determine if mSCs reduced PH. We induced PH Sprague-Dawley rats by Sugen/Hypoxia (3 weeks) followed...
Nódulos de tireóide são uma condição clínica comum e em seu diagnóstico diferencial inclui-se o câncer tireóide. Como é raro, importante conhecer a prevalência nódulos grupos fortemente pre-dispostos para dimensionar impacto adequar estratégias diagnósticas. OBJETIVOS: O objetivo deste estudo foi verificar diagnosticados por ecografia mulheres na maturidade. MÉTODOS: Entre agosto 1996 dezembro 1997 foram avaliadas, forma consecutiva, pacientes do sexo feminino com idade 40 anos ou mais que...
The effects of exercise training on oxidative stress in gastrocnemius rats with pulmonary hypertension were studied. Four groups established: sedentary control (SC), monocrotaline (SM), trained (TC), (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session, at 60% VO2 max. Right ventricular (RV) pressures measured, heart and removed morphometric/biochemical analysis. Lipid peroxidation (LPO), H2O2, GSH/GSSG, activity/expression antioxidant enzymes evaluated. Increased RV...
Acute myocardial infarction (AMI) is one of the major causes heart failure and mortality. Glucocorticoids administration post-infarction has long been proposed, but it shown conflicting results so far. This controversy may be associated with glucocorticoid type period when administered. To elucidate these, present aims to evaluate if brief methylprednisolone acetate determinant for adaptation after AMI. Male Wistar rats were divided into 3 groups: sham-operated (SHAM); infarcted (AMI);...
Oxidative stress is involved in increased pulmonary vascular resistance (PVR) and right ventricular (RV) hypertrophy, characteristics of arterial hypertension (PAH). Copaiba oil, an antioxidant compound, could attenuate PAH damage. This study’s aim was to determine the effects copaiba oil on lung oxidative stress, PVR, mean pressure (mPAP) monocrotaline (MCT) model PAH. Male Wistar rats (170 g, n = 7/group) were divided into four groups: control, MCT, MCT + (MCT-O). induced by (60 mg/kg...
Isolating high-quality different cell types is a powerful approach for understanding cellular compositions and features in the heart, but it challenging. The available protocols typically focus on isolating one or two types. Here, we present protocol to simultaneously isolate high-quantity cardiomyocytes non-myocyte cells, including immune from adult rat hearts. We describe steps purifying cells using bovine serum albumin. also detail procedures viability analysis type identification...
What is the central question of this study? Does thyroid hormone treatment given after myocardial infarction preserve left ventricular function and treadmill exercise performance, improve parameters oxidative stress in right ventricle lungs Wistar rats? main finding its importance? Thyroid improved performance maximum test infarcted rats induced effects heart that were similar to those observed with training. This suggests there a significant value hormones for preserving tolerance...
Purpose: Inflammatory reaction has been experimentally associated with cardiac adaptation to pressure overload leading myocardial fibrosis and heart failure. We have recently demonstrated that endogenous cannabinoids the cannabinoid receptor 2 (CB2) are activated accompanied by persistent inflammation in myocardium of patients aortic valve stenosis. Therefore, we investigated role CB2 a mouse model.
Objectives: Inflammation has been suggested in human aortic aneurysms and associated with remodeling of the vessel wall. Endogenous cannabinoids their receptors have shown to modulate inflammatory response tissue many organs. Therefore, we investigated components endocannabinoid system, inflammation aneurysms.
Objectives: Pulmonary hypertension leads to myocardial adaptation and remodelling, but has deleterious long-term effects on right ventricular function. Endocannabinoid receptor CB2 been associated with protective in remodelling after ischemia. Therefore, we investigated the role of occlusion left pulmonary artery a novel murine model.