A5031405223- Natural product bioactivities and synthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phytochemistry Medicinal Plant Applications
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Traditional and Medicinal Uses of Annonaceae
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Fungal Infections and Studies
- Carbohydrate Chemistry and Synthesis
- Analytical Chemistry and Chromatography
- Plant Pathogens and Fungal Diseases
- Plant and animal studies
- Phytochemicals and Antioxidant Activities
- Biochemical Analysis and Sensing Techniques
- Bioactive Compounds and Antitumor Agents
- Synthesis of Organic Compounds
- Plant and Fungal Species Descriptions
- Fermentation and Sensory Analysis
- Synthesis and biological activity
- Analytical chemistry methods development
- Microbial Natural Products and Biosynthesis
Universidade Federal de Goiás
2015-2024
University of Copenhagen
2019
Universidade Estadual de Campinas (UNICAMP)
1996-2003
Narrow-leafed lupin (NLL, Lupinus angustifolius) is a promising legume crop that produces seeds with very high protein content. However, NLL accumulates toxic quinolizidine alkaloids (QAs) in most of its tissues, including the seeds. To determine level situ biosynthesis seeds, we compared accumulation QAs expression biosynthetic gene lysine decarboxylase (LDC) developing and pods bitter (high-QA) variety NLL. While accumulated steadily until drying phase, LDC was comparatively low throughout...
The great potential of plants as Hymenaea courbaril L (jatoba) has not yet been throughly explored scientifically and therefore it is very important to investigate their pharmacological toxicological activities establish real efficacy safety. This study investigated the cytotoxicity xylem sap its bioactivity against fungi Cryptococcus neoformans species complex dermatophytes. fresh H. was filtered resulting in an insoluble brown color precipitate identified fisetin. In filtrate mixture...
Indole alkaloids and synthetic indole derivatives are well known for their therapeutic importance. In fact, preclinical clinical studies had already demonstrated several pharmacological activities these compounds. Here, we overview the multifunctional potential of molecules inhibition enzymes related to neurodegenerative disease: acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidases A B (MAO-A MAO-B). focus will be given on Psychotria L. genus, considering its...
A atividade antioxidante, avaliada pelo método DPPH (1,1-difenil-2-picrilidrazila), e o teor em compostos fenólicos totais do extrato bruto metanólico frações das folhas da espécie Palicourea rigida Kunth, Rubiaceae, foram quantificadas neste trabalho. Apesar baixa apresentada (500 ppm), a fração acetato de etila apresentou moderada (192 ppm) maior dentre as ensaiadas. Assim, foi submetida procedimentos cromatográficos que resultou no isolamento dos flavonoides quercetina 3-O-β-D-glicosídeo,...
Protein tyrosine phosphatase 1B (PTP1B) is an intracellular enzyme responsible for deactivation of the insulin receptor, and consequently acts as a negative regulator signal transduction. In recent years, PTP1B has become important target controlling resistance type 2 diabetes. present study, ethyl acetate extract leaves Miconia albicans (IC50 = 4.92 µg/mL) was assessed by high-resolution inhibition profiling combined with HPLC-HRMS-SPE-NMR identification antidiabetic compounds. This...
ABSTRACT Paracoccidioides is the agent of paracoccidioidomycosis. Malate synthase plays a crucial role in pathogenicity and virulence various fungi, such as those that are human pathogens. Thus, an inhibitor this enzyme may be used powerful antifungal without side effects patients once these enzymes absent humans. Here, we searched for compounds with inhibitory capacity against malate species ( Pb MLS). The three-dimensional (3D) structure MLS was determined using I-TASSER server. Compounds...
The dimorphic fungus Paracoccidioides spp. is responsible for paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America, causing serious public health problems. Adequate treatment of mycotic infections difficult, since fungi are eukaryotic organisms with a structure and metabolism similar to those hosts. In this way, specific targets have become important search new antifungal compound. role glyoxylate cycle its enzymes microbial virulence has been reported many fungal...
The leaves of Hyptis ovalifolia Benth. (Lamiaceae) were subjected to hydrodistillation and the resulting volatiles investigated by GC/MS. main constituent representing 60% essential oil was isolated column chromatography identified spectroscopic methods as (R)-6-[(Z)-1-heptenyl]-5,6-dihydro-2H-pyran-2-one (1). This compound showed strong in vitro activity against four dermatophyte fungi Microsporum canis, gypseum, Tricophyton mentagrophytes, rubrum (a total 60 strains) with a minimal...
O estudo químico de Aloysia gratissima (Gillies & Hook.) Tronc. e virgata (Ruiz Pav.) Pers., Verbenaceae, resultou no isolamento quatorze substâncias. Suas estruturas foram determinadas com base nos dados IV, RMN ¹H 13C uni bidimensionais comparação da literatura. A atividade antibacteriana do extrato bruto das folhas caules frações A. virgata, bem como as substâncias hoffmaniacetona seu monoacetato, verbascosídeo arenariosídeo, avaliadas através método bioautografia a antiedematogênica foi...
The biological activity of crude extract and fractions Hymenaea martiana was evaluated against a panel human pathogenic fungi. extracts hydroalcoholic (E) showed high Cryptococcus neoformans species complex isolates with MICs between 2 64 μg ml(-1). methanolic (C) butanolic (D) were the most active Trichopyton rubrum, mentagrophytes Microsporum canis 8 256 None yeast Malassezia furfur, obtusa sympodialis.
The genus Banisteriopsis (Malpighiaceae) comprises 77 genera and 1,300 species. Despite efforts to provide detailed information about the chemical wealth of B. laevifolia, this article provides identification characterization compounds from ethanolic extracts leaves flowers using advanced methodologies which include high-performance liquid chromatography coupled tandem mass spectrometry, contribute knowledge present in Banisteriopsis. dereplication aided by Global Natural Products Social...