A5057186704- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Alzheimer's disease research and treatments
- Air Quality and Health Impacts
- Coffee research and impacts
- Cardiac Ischemia and Reperfusion
- Climate Change and Health Impacts
- Nuclear Receptors and Signaling
- Cholesterol and Lipid Metabolism
- Exercise and Physiological Responses
- Atherosclerosis and Cardiovascular Diseases
- Muscle metabolism and nutrition
- Eating Disorders and Behaviors
- Cardiac Fibrosis and Remodeling
- Autoimmune and Inflammatory Disorders Research
- Natural Antidiabetic Agents Studies
- Lipid metabolism and biosynthesis
- Medicinal Plants and Neuroprotection
- Inflammation biomarkers and pathways
- COVID-19 impact on air quality
- thermodynamics and calorimetric analyses
- Inflammasome and immune disorders
Universidade Federal do Rio Grande do Sul
2021-2024
Universidade do Extremo Sul Catarinense
2016-2023
Centro Universitário do Espírito Santo
2016-2023
Universidade Federal do Rio Grande
2023
University of Rio Grande and Rio Grande Community College
2022
Universidade Federal de Santa Catarina
2022
University of Coimbra
2022
Universidade do Sul de Santa Catarina
2020
Insulin resistance is the link between obesity and type 2 diabetes mellitus. The molecular mechanism by which obese individuals develop insulin has not yet been fully elucidated; however, inconclusive contradictory studies have shown that oxidative stress may be involved in process. Thus, this study aimed to evaluate effect of reactive species on diet-induced mice. Obese insulin-resistant mice were treated with N-acetylcysteine (NAC; 50 mg/kg per day, for 15 days) means oral gavage....
Maple Syrup Urine Disease (MSUD) is an autosomal recessive inherited disorder, caused by a deficiency on branched chain α‐ketoacid dehydrogenase complex activity, resulting in accumulation of branched‐chain amino acids (BCAA) (e.g. leucine). The treatment MSDU patients increases survival time and quality life. Thus, nowadays there are crescent number adolescents adults with MSUD. Relevant studies have been reported behavioral alterations these patients, i.e. high risk chronic...
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. We investigated the effect of prior 30 days voluntary exercise protocol on STZ-diabetic CF1 mice. Glycemia, and liver skeletal muscle glycogen, mitochondrial function, redox status were analyzed up to 5 after STZ injection. Animals engaged in following groups: Sedentary vehicle (Sed Veh), STZ), Exercise Vehicle (Ex STZ). prevented fasting hyperglycemia Ex group. In liver, there was decreased glycogen level Sed group...
Abstract Familial hypercholesterolemia (FH) is caused by mutations in the gene that encodes low‐density lipoprotein (LDL) receptor, which leads to an excessive increase plasma LDL cholesterol levels. Previous studies have shown FH associated with gliosis, blood–brain barrier dysfunction, and memory impairment, but mechanisms these events are still not fully understood. Therefore, we aimed investigate role of microgliosis neurochemical behavioral changes using receptor knockout (LDLr −/− )...
ABSTRACT Hypercholesterolemia has been associated with cognitive dysfunction and neurodegenerative disease. Moreover, this metabolic condition disrupts the blood-brain barrier, allowing Low-Density Lipoprotein (LDL) to enter Central Nervous System. Thus, we investigated effects of LDL exposure on mitochondrial function in a mouse hippocampal neuronal cell line (HT-22). HT-22 cells were exposed human (50 300 μg/mL) for 24 hours. After this, intracellular lipid droplet (LD) content, viability,...
Abstract Caffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported mechanism caffeine through neuronal A 2A R antagonism central nervous system [1]. We now demonstrate that striatum rules effects neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) twenty-four C57BL/6J 23.9 0.4 adult male mice were studied behaviorly electrophysiologically using energy metabolism was SH-SY5Y cells. Systemic (15 mg/kg, i.p.) or striatal (bilateral, 15...
Abstract Background Familial hypercholesterolemia (FH) is a clinical condition characterized by increased plasma cholesterol levels, due to mutation in the gene encoding low‐density lipoprotein receptor (LDLr) cells [Brown and Goldstein, 1984] . Importantly, evidence indicates that FH negatively affects cognition favors development of neuropathologies [Ariza et al., 2016; Zambón al, 2010] , however, mechanisms behind this relationship are still not fully understood. In study we aimed...
Abstract Background Low‐density lipoprotein (LDL) is responsible for the transport of cholesterol to peripheric tissues (Cortes et al. 2014), and it enters cells via LDL receptors (LDLr) (Luo, Yang, Song 2020). Cholesterol metabolism alterations, i.e., hypercholesterolemia are well‐known cardiovascular risk factors have also been linked cognitive behavioral alterations (De Oliveira 2011, Sparks 1990, WHO 2008). Familial (FH) a prevalent disease caused by dysfunctions (Akioyamen 2017),...