A5053051194- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Birth, Development, and Health
- Anesthesia and Neurotoxicity Research
- Fatty Acid Research and Health
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Early Childhood Education and Development
- Resilience and Mental Health
- Science and Education Research
- Child Abuse and Trauma
- Neonatal and fetal brain pathology
- Neurological Disease Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Neurogenesis and neuroplasticity mechanisms
- Coffee research and impacts
- Zebrafish Biomedical Research Applications
- Regulation of Appetite and Obesity
- Mental Health Research Topics
Universidade Federal do Rio Grande do Sul
2014-2024
University of Minho
2023-2024
Universidade Federal de Ciências da Saúde de Porto Alegre
2012
Grooming behavior is an adaptation to a stressful environment that can vary in accordance with stress intensity. Direct and indirect GABAA receptor agonists decrease duration, frequency, incorrect transitions uninterrupted bouts of grooming. Hormonal variation during the different phases estrous cycle female rats also changes grooming behavior. It known endogenous hormones change anxiety-like behaviors observed elevated plus maze test, classical animal model anxiety. This study was designed...
Neonatal handling (H) and maternal separation (MS) both induce changes in care, but the contribution of these to behavioral neurochemical outcomes offspring remains unclear, as studies often find opposite results concerning frequency behaviors, particularly MS paradigm. In this study, behavior displayed by H, non-handled (NH) Wistar rat dams were observed during first 10days after birth. A tentative assessment quality care was made, using a previously reported score that reflects...
Cocaine sensitization is a marker for some facets of addiction, greater in female rats, and may be influenced by their sex hormones. We compared the modulatory effects endogenous or exogenous estradiol progesterone on cocaine-induced behavioral 106 rats. Ovariectomized rats received (0.5 mg/mL), (0.05 plus estradiol, oil vehicle. Sham-operated control females oil. Control acute subgroups injections saline, while repeated group cocaine (15 mg/kg, ip) 8 days. After 10 days, groups challenge...
Early life experiences program lifelong responses to stress. In agreement, resilience and vulnerability psychopathologies, such as posttraumatic stress disorder (PTSD), have been suggested depend on the early background. New therapies targeted memory reconsolidation a strategy modify emotional valence of traumatic memories. Here, we used animal models study molecular mechanism through which may later affect aversive reconsolidation. Handling (H)-separation pups from dams for 10 min-or...
Among the public health recommendations for supporting mental during COVID-19 pandemic, many strategies had an impact on biological rhythms, like sleep hygiene, physical exercise and healthy eating habits. Considering known relationship between circadian organization health, our aim was to test association behavioral regularity its interaction with chronotype, in a large sample surveyed Brazil. We collected longitudinal data using online questionnaires that assessed sociodemographic...
Alterations in GABA(A) receptor expression have been associated with the allopregnanolone (3α-hydroxy-5α-pregnan-20-one; 3α,5α-THP) antidepressant-like effect rats. The present study aimed to verify of bilateral, intra-nucleus accumbens core (intra-AcbC) administration neurosteroid on behaviors forced swim and grooming microstructure tests δ γ2 subunit mRNA right left hippocampus results this showed that intra-AcbC (5μg/rat) presented activity test concomitant an increase climbing....
Abstract Childhood and adolescence are sensitive periods of development, marked by high brain maturation plasticity. Exposure to early life stress, such as social isolation, is able prompt changes in circuitries, essentially the mesolimbic dopaminergic system increase risk for addictive behaviors later life. Post‐weaning isolation can stimulate consumption rewarding substances, like drugs abuse palatable foods. However, most studies analyze long very little known about effects a brief period...
Abstract Several environmental factors affect child development, such as the intrauterine environment during embryonic and fetal development early postnatal provided by maternal behavior. Although mechanistic effects of exercise on offspring health improvement are not yet completely understood, number reports published demonstrating positive influence have increase. Herein, we addressed issues related to behavior developmental physical landmarks, sensorimotor reflexes, motor movements...
Objective: To assess the adherence to a set of evidence-based recommendations support mental health during coronavirus disease 2019 (COVID-19) pandemic and its association with depressive anxiety symptoms. Methods: A team workers researchers prepared recommendations, formatted into three volumes (1: COVID-19 prevention; 2: Healthy habits; 3: Biological clock sleep). Participants were randomized receive only Volume 1 (control), Volumes 2, 3, or all volumes. We used convenience sample...
Chronic cerebral hypoperfusion (CCH) leads to memory and learning impairments associated with degeneration gliosis in the hippocampus. Treatment physical exercise carries different therapeutic benefits for each sex. We investigated effects of acrobatic training on astrocyte remodeling CA1 CA3 subfields hippocampus spatial impairment male female rats at stages two-vessel occlusion (2VO) model.
Early life stress may lead to lifelong impairments in psychophysiological functions, including emotional and reward systems. Unpredicted decrease magnitude generates a negative state (frustration) that be involved with susceptibility psychiatric disorders. We evaluated, adolescents adult rats of both sexes, whether maternal separation (MS) alters the ability cope an unexpected reduction later life. Litters Wistar were divided into controls (non handled − NH) or subjected MS. Animals trained...
Neonatal handling has an impact on adult behavior of experimental animals and is associated with rapid increased palatable food ingestion, impaired behavioral flexibility, fearless to novel environments. These symptoms are characteristic features impulsive trait, being controlled by the medial prefrontal cortex (mPFC). Impulsive a key component many psychiatric disorders such as attention deficit hyperactivity disorder (ADHD), manic behavior, schizophrenia. Others have reported...
Abstract Prenatal and early postnatal periods are important for brain development neural function. Neonatal insults such as hypoxia‐ischemia (HI) causes prolonged metabolic dysregulation, affecting central nervous system maturation. There is evidence that hypometabolism could increase the risk of adult‐onset neurodegenerative diseases. However, impact non‐pharmacologic strategies to attenuate HI‐induced glucose dysfunction still underexplored. This study investigated long‐term effects...
Exposure to artificial sweeteners, such as aspartame, during childhood and adolescence has been increasing in recent years. However, the safe use of aspartame questioned owing its potentially harmful effects on developing brain. The aim this study was test whether chronic consumption leads a depressive-like phenotype investigate possible mechanisms underlying these behavioral changes.Adolescent male female rats were given unlimited access either water, solutions or sucrose their home cages...
We investigated the effect of a chronic palatable diet rich in simple sugars on memory different degrees emotionality male adult rats, and hippocampal plasticity markers stages development. On postnatal day (PND) 21, 45 Wistar rats were divided two groups, according to their diet: (1-Control) receiving standard lab chow or (2-Palatable Diet) both plus ad libitum. At PND 60, behavioral tests performed investigate distinct tasks. Hippocampal at 28 half animals, after tests. Palatable...