A5021575415- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Genetic Neurodegenerative Diseases
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Biochemical and Molecular Research
- Antibiotic Use and Resistance
- Food Allergy and Anaphylaxis Research
- Healthcare Regulation
- S100 Proteins and Annexins
- Lysosomal Storage Disorders Research
- Neuroscience and Neuropharmacology Research
- Public Health in Brazil
- Neonatal Health and Biochemistry
- Neonatal and fetal brain pathology
- Immune Response and Inflammation
- Oral microbiology and periodontitis research
- Neonatal Respiratory Health Research
- Biochemical Acid Research Studies
- Metabolomics and Mass Spectrometry Studies
- Alcoholism and Thiamine Deficiency
- Traumatic Brain Injury and Neurovascular Disturbances
- IL-33, ST2, and ILC Pathways
- Folate and B Vitamins Research
Universidade Federal do Rio Grande do Sul
2019-2024
Arizona State University
2023
Universidade Federal do Rio Grande
2022
Universidade Regional Integrada do Alto Uruguai e das Missões
2017
Neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, where glial cells, such as microglia astrocytes, play key roles in activation maintenance inflammatory responses central nervous system. now known to involve neurometabolic shift, addition an increase energy consumption. We used two approaches (in vivo ex vivo) evaluate effects lipopolysaccharide (LPS)-induced neuroinflammation on reprogramming, modulation glycolytic pathway...
Metabolic dysfunction-associated fatty liver disease (MAFLD) has gained worldwide attention as a public health problem. Nonetheless, lack of enough mechanistic knowledge restrains effective treatments. It is known that thyroid hormone triiodothyronine (T3) regulates hepatic lipid metabolism, and mitochondrial function. Liver dysfunction type 3 deiodinase (D3) contributes to MAFLD, but its role not fully understood. Objective: To evaluate the D3 in progression MAFLD an animal model....
Tissue accumulation and high urinary excretion of ethylmalonic acid (EMA) are found in encephalopathy (EE), an inherited disorder associated with cerebral cerebellar atrophy whose pathogenesis is poorly established. The vitro vivo effects EMA on bioenergetics redox homeostasis were investigated rat cerebellum. For the studies, cerebellum preparations exposed to EMA, whereas intracerebellar injection was used for evaluation. reduced state 3 uncoupled respiration succinate-, glutamate-,...
A resistência bacteriana tem sido descrita como preocupação mundial e está relacionada a diversos fatores como: uso abusivo de antimicrobianos, automedicação, falta conhecimento e/ou descumprimento por parte dos profissionais envolvidos no tratamento. Frente isso, Agência Nacional Vigilância Sanitária (ANVISA) criou Resolução Diretoria Colegiada (RDC) 20/2011 com finalidade facilitar dispensação controlar o consumo antimicrobianos. O presente estudo analisar prescrições antimicrobianos orais...
Metabolic dysfunction associated fatty liver disease (MAFLD) has gained worldwide attention as a public health problem. Nonetheless, lack of enough mechanistic knowledge restrains effective treatments. It is known that T3 regulate hepatic lipid metabolism, and mitochondrial function. Liver contributes to MAFLD, but its role not fully understood. Objective: To evaluate the in progression MAFLD an animal model. Method-ology: Male/adult Sprague Dawley rats (n=20) were allocated control group...
Abstract Background Human exposure to pesticides is increasing, especially glyphosate‐based herbicides (GBH). Thus, it of great interest characterize whether glyphosate (Gly) exerts neurotoxic effects. Besides Gly, GBH formulations contain adjuvants, mainly POEA, a surfactant. We hypothesize adjuvants may enhance neurotoxicity. Therefore, we aimed at investigating the properties Gly and its adjuvants. Method Gly+POEA, were orally administered into male Wistar rats (90‐day‐old, n = 30) for 28...