A5000289894- Prostate Cancer Treatment and Research
- Muscle metabolism and nutrition
- Prostate Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Exercise and Physiological Responses
- Sepsis Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Acute Kidney Injury Research
- Reproductive Biology and Fertility
- High Altitude and Hypoxia
- Male Reproductive Health Studies
- Cardiovascular and exercise physiology
- RNA Interference and Gene Delivery
- Intensive Care Unit Cognitive Disorders
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Women's cancer prevention and management
- Sports injuries and prevention
- Plant-derived Lignans Synthesis and Bioactivity
- Neonatal and Maternal Infections
- Paleopathology and ancient diseases
- Apelin-related biomedical research
Universidade Federal de Ciências da Saúde de Porto Alegre
2012-2025
Universidade Federal do Rio Grande do Sul
2008-2022
Santa Casa de Misericórdia de Marília
2022
Universidade Estadual Paulista (Unesp)
2021
Weatherford College
2021
Hospital de Clínicas de Porto Alegre
2017
Abstract Introduction: Acute kidney injury (AKI) in the setting of COVID-19 is associated with worse clinical and renal outcomes, limited long-term data. Aim: To evaluate critically ill patients AKI that required nephrologist consultation (NC-AKI) a tertiary hospital. Methods: Prospective single-center cohort adult NC-AKI from May 1st, 2020, to April 30th, 2021. Kidney replacement therapy (KRT), recovery function, death at 90-day 1-year follow-up were evaluated. Results: 360 included, 60.6%...
Resumo Introdução: IRA no contexto da COVID-19 associa-se a piores desfechos clínicos e renais, com dados limitados de longo prazo. Objetivo: Avaliar pacientes críticos necessidade consultoria nefrológica (IRA-CN) em hospital terciário. Métodos: Coorte prospectiva centro único adultos IRA-CN 01/05/2020 30/04/2021. Avaliou-se terapia renal substitutiva (TRS), recuperação função óbito 90 dias 1 ano. Resultados: Incluímos 360 pacientes, 60,6% homens, idade mediana 66,0 (57,0-72,0) anos, 38,1%...
Progesterone is a neuroactive hormone with non‐genomic effects on GABA A receptors (GABA R). Changes in the expression of R subunits are related to depressive‐like behaviors rats. Moreover, sex differences and depressive have been associated prefrontal brain asymmetry rodents humans. Thus, our objective was investigate effect progesterone α 1 γ 2 mRNA right left cortex diestrus female male rats exposed forced swimming test (FST). Male ( n = 8/group) were randomly selected receive daily dose...
<b><i>Background/Aim:</i></b> Granulosa cells are the source of most important ovarian steroids. Even in patients without significant improvement metabolic parameters, metformin has apparently an effect on ovary. The aim this study was to evaluate gene and protein expression insulin receptor (IR), insulin-like growth factor-1 (IGF1) (IGF1R) aromatase granulosa treated with insulin. <b><i>Methods:</i></b> Luteinized were collected from 27 during...
The role of molecular changes in the androgen receptor (AR) as AR variants (AR-Vs) is not clear pathophysiology benign prostatic hyperplasia (BPH) and hormone-naïve PCa. aim current work was to identify presence isoforms tissue primary PCa, evaluate possible association with tumor aggressiveness biochemical recurrence mRNA levels full length (AR-FL) AR-Vs (AR-V1, AR-V4 AR-V7) were measured using RT-qPCR. protein expression AR-FL (AR-CTD AR-NTD) AR-V7 evaluated by H-Score immunohistochemistry...
Uterine leiomyomas are the most common benign smooth muscle cell tumors in women. Estrogen (E2), progesterone (P4) and environmental factors play important roles development of these tumors. New treatments, such as mifepristone, have been proposed. We evaluated gene expression total (PRT) B (PRB) receptors, histone acetyltransferase (HAT) deacetylase (HDAC) activity after treatment with E2, P4 mifepristone (RU486) primary cultures from uterine leiomyoma normal myometrium. Compared to...
Abstract Hypotension is one of the main characteristics systemic inflammation, basically caused by endothelial dysfunction. Studies have shown that amino acid L‐kynurenine (KYN) causes vasodilation in mammals, leading to hypotensive shock. In shock, when activated KYN, voltage‐gated potassium channel encoded family KCNQ (Kv7) gene can cause vasodilation. Fructose‐1,6‐bisphosphate (FBP) it being considered studies an anti‐inflammatory, antioxidant, immunomodulator, and a modulator some ion...
Introduction The diagnosis of sepsis is based on expert consensus and does not yet have a “gold standard.” With the aim improving standardizing diagnostic methods, there already been three major consensuses subject. However, are still few studies in middle-income countries comparing methods. This study describes characteristics patients diagnosed with evaluates compares performance Sepsis-1, 2, 3 criteria predicting 28 days, in-hospital mortality. Patients Methods A retrospective...
Aim: To evaluate the impact of exercise training plasma on in vitro prostate cancer cell viability and proliferation. Methods: PC3 cells were incubated with obtained from young men high low physical fitness (PF) (high PF, n = 5; 5) collected institutionalized older adults (n 8) before after multimodal training. Cell proliferation, mitochondria membrane polarization, reactive oxygen species (ROS) generation, apoptosis evaluated treatment plasma. Systemic cytokines submitted to an protocol....
Prostate cancer (PCa) is one of the most prevalent male tumours. Stanniocalcin-1 (STC1) a glycoprotein and, although role STC1 in human poorly understood, it suggested to be involved development and progression different neoplasms. This study investigated protein expression profile PCa benign prostatic hyperplasia (BPH) samples signalling during cell proliferation death vitro using lines. We found higher levels when compared BPH tissue that inhibited forskolin stimulation cAMP PC-3 cells. A...
Abstract Fructose‐1,6‐bisphosphate (F1,6 BP ), an intermediate of the glycolytic pathway, has been found to play a promising anticancer effect; nevertheless, mechanisms involved remain poorly understood. The present study aimed evaluate effect and F1,6 in human endometrial cancer cell line (Ishikawa). showed antiproliferative non‐cytotoxic on cells. These effects are related increase reactive oxygen species (ROS) levels mitochondrial membrane potential (ΔΨm). harmful stimuli trigger...
Objectives The aim of this study was to ascertain whether pattern cutaneous lesions, age, sex, ethnicity, long-term medication use, arterial oxygen saturation at the first examination, setting care, and number medications used treat SARS-CoV-2 infection are associated with mortality in patients a confirmed diagnosis coronavirus disease 2019 (COVID-19) manifestations. In addition, evaluate occurrence manifestations COVID-19 through review medical records in-person evaluation by dermatologist....
This study aimed to describe sepsis progression in critical COVID-19 patients using the SOFA score and investigate its relationship with mortality.Three researchers collected analyzed retrospective clinical laboratory data found electronic health records from all admitted a severe exclusive intensive care unit March 2020 October 2020. Mixed-effect logistic regression was used evaluate (Sepsis-3) variables as mortality prediction markers, while Kaplan-Meier survival curves were compare...