A5030766745- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Biomedical Ethics and Regulation
- Cancer survivorship and care
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Diversity and Career in Medicine
- Cell death mechanisms and regulation
- Surgical Simulation and Training
- Cancer, Hypoxia, and Metabolism
- Pelvic and Acetabular Injuries
- Enhanced Recovery After Surgery
- Phagocytosis and Immune Regulation
- Body Contouring and Surgery
- Pancreatic and Hepatic Oncology Research
- Telemedicine and Telehealth Implementation
- Glaucoma and retinal disorders
- DNA Repair Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Bladder and Urothelial Cancer Treatments
- HER2/EGFR in Cancer Research
- Physiological and biochemical adaptations
- Advanced Breast Cancer Therapies
- Erythrocyte Function and Pathophysiology
- Prostate Cancer Treatment and Research
Montefiore Medical Center
2021-2024
Jilin University
2024
Cornell University
2021
Albany Medical Center Hospital
2021
Duke University
2017-2020
Duke University Hospital
2019
Duke Medical Center
2018-2019
Universidade Federal de Ciências da Saúde de Porto Alegre
2019
Yahoo (United Kingdom)
2019
Duke Cancer Institute
2019
The tumor microenvironment within the breast is rich in adipose elements. interaction between cells and cancer poorly understood, particularly as it pertains to patients with genetic susceptibility cancer. This study focuses on phenotype of human adipose-derived stem BRCA1 mutation effect they may have cell behavior.CRISPR/Cas9 was used generate de novo BRCA1-knockdown cells. knockdown compared wild-type patient-derived known mutations. Interactions MDA-MB-231 line were...
ATM is a well-known master regulator of double strand break (DSB) DNA repair and the defective has been therapeutically exploited to develop PARP inhibitors based on synthetic lethality strategy. mutation found with increased prevalence in advanced metastatic castration-resistant prostate cancer (mCRPC). However, molecular mechanisms underlying mutation-driving disease progression are still largely unknown. Here, we report that contributes CRPC through metabolic rather than mechanism. We...
CD90 has been identified as a candidate marker of cancer stem cells (CSCs) for HCC, whereas it also considered tumor-associated fibroblasts (CAFs). OCT4, key transcription factor required to maintain pluripotency human embryonic cell and cells, characterized be involved in malignant transformation tumorigenesis various cancers. This study aimed examine expression patterns HCC investigate whether combination both OCT4 could provide more powerful predictor prognosis than either one alone.CD90...
Background: Revision procedures address contour irregularities and aesthetic concerns following autologous breast reconstruction. Mental health diagnoses are known to influence patient satisfaction with The authors aimed identify oncologic, reconstructive, demographic factors, including mental diagnoses, associated the number of revisions after Methods: medical records all adult women undergoing abdominal free flap–based reconstruction at a major academic institution between 2011 2016 were...
Background Breast implant placement is the most common method for postmastectomy reconstruction. For patients who develop complications associated with implant-based reconstruction, additional surgeries may be challenging. This study examined reconstruction failure in undergoing salvage abdominal free tissue transfer. Methods We conducted an Institutional Review Board approved, multicenter retrospective of primary breast followed by removal and subsequent transfer between 2006 2016. Patient...
Background Perforator mapping with computed tomography angiography (CTA) prior to autologous breast reconstruction reduces donor-site morbidity and operative time, but is costly. The aim of this study was evaluate whether pre-existing CT scans could be used for dominant perforator identification before reconstruction. Methods We identified all female patients who underwent mastectomy immediate or delayed abdominal free flaps at a single institution between 2006 2016. Medical records were...
Prostate cancer (PCa) is one of the most prevalent male tumours. Stanniocalcin-1 (STC1) a glycoprotein and, although role STC1 in human poorly understood, it suggested to be involved development and progression different neoplasms. This study investigated protein expression profile PCa benign prostatic hyperplasia (BPH) samples signalling during cell proliferation death vitro using lines. We found higher levels when compared BPH tissue that inhibited forskolin stimulation cAMP PC-3 cells. A...
Since the first documented case of coronavirus disease 2019 (COVID-19), greater New York City area quickly became epicenter global pandemic, with over 500,000 cases and 50,000 deaths. This unprecedented crisis affected all aspects health care, including plastic surgery residency training. The purpose this study was to understand specific impact COVID-19 pandemic on residencies.A survey training programs in conducted. during peak months infection (March April 2020) evaluated using resident...
Abstract Goals/Purpose The current standard of care for providing postoperative instructions to patients undergoing elective, ambulatory surgeries often falls short in efficiency, clarity, and patient-centeredness. Patients are given a single set written at the time discharge after their surgery, which leads confusion increased reliance on phone calls, urgent clinic appointments, even unnecessary visits emergency department. Recognizing this, we propose quality improvement initiative enhance...
Abstract Background Unplanned returns to the operating room (OR) may be necessary at times salvage a compromised free flap. The aim of this study was assess influence attending surgeon continuity on flap outcomes following return OR. Methods We retrospectively reviewed patients who underwent reconstruction and experienced an unplanned OR within 30 days from 2002 2017. Logistic regression modeling used determine factors that predict Results Of 1,177 were identified, 267 (22.5%) had these, 69...
INTRODUCTION: The tumor microenvironment can influence the progression of breast cancer. Targeting active pathways within may be especially beneficial for triple negative cancer (TNBC). Our study focuses on phenotype human adipose-derived stem cells (ASCs) with BRCA1 mutation and resulting effects cells. We hypothesize that BRCA1, a DNA damage response protein, induces cell senescence in ASCs promotes secretion inflammatory cytokines, which leads to increased invasion metastasis. METHODS:...
PURPOSE: We have previously shown that human breast adipose-derived stem cells (ASC) from BRCA mutation carriers behave differently non-mutation in regards to adipocyte differentiation and cytokine production. It is unknown if the impacts adipose tissue a manner promotes cancer. In this study we further investigate effects mutations on interaction between ASCs cancer cells. METHODS: BRCA1-knockout were generated using CRISPR/Cas9 system commercially available ASC lines. BRCA1 protein...
PURPOSE: Hospitals are evaluated for quality based on a number of metrics including the occurrence complications. Urinary tract infections (UTI) among most common healthcare-associated infections, with majority seen after prolonged urinary catheterization. The Enhanced Recovery After Surgery (ERAS) protocol calls early removal catheters. In this study, we compare rate UTI in patients who have undergone traditional recovery surgery (pre-ERAS) to those were enrolled ERAS (post-ERAS). We...
Purpose: Patient satisfaction after breast reconstruction is multifactorial. How prior aesthetic surgery affects patient reported outcome has not been reported. This study investigates the influence of on patients who undergo reconstruction. Methods: We retrospectively reviewed all underwent from 2014-2020. Patients were included in this if they had completed Breast-Q survey preoperatively, then 6 month, 1 year, and 2 years postoperatively. demographics, comorbidities, overall complications,...