A5002285635- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Mesenchymal stem cell research
- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Treatment of Major Depression
- Respiratory Support and Mechanisms
- Epilepsy research and treatment
- 3D Printing in Biomedical Research
- Birth, Development, and Health
- Pluripotent Stem Cells Research
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Genetics and Neurodevelopmental Disorders
- Mental Health and Psychiatry
- Tissue Engineering and Regenerative Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Interference and Gene Delivery
Hospital São Rafael
2010-2024
D’Or Institute for Research and Education
2021-2024
Instituto do Cérebro
2017-2022
Pontifícia Universidade Católica do Rio Grande do Sul
2010-2021
Universidade Federal de Santa Maria
2021
Fundação Oswaldo Cruz
2010
Universidade Federal do Rio Grande do Sul
2010
Inflammation could be a risk factor for the development of depression and change outcome this common chronic-recurrent mental disorder.This study aimed to investigate if bone marrow mononuclear cell (BMMC) transplantation is effective in restoring sucrose preference rats subjected chronic stress (CS), it has an anti-inflammatory effect able restore damaged DNA.The BMMC was studied controlled protocol (compared with control group selective serotonin reuptake inhibitor escitalopram group)...
Normal ageing results in brain selective neuronal and glial losses. In the present study we analyze changes Wistar rats at two different ages, 45 days (young) 420 (mature adult), using Nissl staining fibrillary acidic protein (GFAP) immunohistochemistry associated to Sholl analysis. Comparing mature adults with young noted former a decrease density cerebral cortex, corpus callosum, pyriform L.D.D.M., L.D.V.L., central medial thalamic nucleus zona incerta. A was found dorsomedial ventromedial...
It is well recognized that stress or glucocorticoids hormones treatment can modulate memory performance in both directions, either impairing enhancing it. Despite the high number of studies aiming at explaining effects on memory, this has not yet been completely elucidated. Here, we demonstrate a low daily dose methylprednisolone (MP, 5mg/kg, i.p.) administered for 10-days favors aversive persistence adult rats, without any effect exploring behavior, locomotor activity, anxiety levels and...
The global challenge posed by the prolonged COVID-19 pandemic underscores critical need for ongoing genomic surveillance to identify emerging variants and formulate effective public health strategies. This retrospective observational study, conducted in a reference hospital Northeast Brazil comprising 2116 cases, employed PCR genotyping together with epidemiological data elucidate impact of Gamma variant during its emergence, revealing distinct patterns hospitalization rates, severity...
Mesenchymal stromal cells are multipotent present in various tissues that widely studied for relevant therapeutic potential due to their paracrine immunomodulatory and tissue regenerating properties. Many mesenchymal cell-based products under investigation the treatment of different clinical conditions. Recently, extracellular vesicles released by these has been focus, with emphasis on translation. Sterility testing during manufacture before final release advanced therapy medicinal markets...
Abstract Undernourishment is a global issue, especially in developing countries, affecting newborns and children vulnerable period of brain development. Previous studies undernourishment models suggested relationship between epilepsy. The exposure to both recurrent seizures early life appears have detrimental effects on the brain. This study aims investigate neurobiological consequences life, investigating Long‐Term Potentiation (LTP) induction gene expression NMDA receptor subunits...
Abstract Background Extracellular vesicles (EVs) represent a new axis of intercellular communication that can be explored for therapeutic purposes; they have garnered considerable attention their potential as cell-free therapy. The clinical application mesenchymal stromal cell (MSC)-derived EVs is still in its infancy and faces many challenges. heterogeneity inherent to MSCs, differences among donors, tissue sources, variations manufacturing conditions may influence the release cargo, thus...