A5009706375- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Olfactory and Sensory Function Studies
- Nasal Surgery and Airway Studies
- Biochemical Analysis and Sensing Techniques
- Nerve injury and regeneration
- Surgical Simulation and Training
- Biochemical effects in animals
- Time Series Analysis and Forecasting
- Thyroid and Parathyroid Surgery
- Advanced Chemical Sensor Technologies
- Engineering Technology and Methodologies
- Cleft Lip and Palate Research
- Venous Thromboembolism Diagnosis and Management
- Mycobacterium research and diagnosis
- Parathyroid Disorders and Treatments
- Oral and Maxillofacial Pathology
- Esophageal and GI Pathology
- Neurobiology and Insect Physiology Research
- Anatomy and Medical Technology
- Radiology practices and education
- Vascular Malformations and Hemangiomas
- Airway Management and Intubation Techniques
- Infectious Diseases and Mycology
- Inflammatory Biomarkers in Disease Prognosis
Monell Chemical Senses Center
2021-2023
Jikei University School of Medicine
2014-2022
Dokkyo Medical University
2013-2020
Kyushu University
2016
Mizuho (Japan)
2016
Reverse transcription-quantitative polymerase chain reaction is a valuable and reliable method for gene quantification. Target expression usually quantified by normalization using reference genes (RGs), accurate critical producing data. However, stable RGs in nasal polyps sinonasal tissues from patients with chronic rhinosinusitis (CRS) have not been well investigated. Here, we used two-stage study design to identify RGs. We assessed the stability of 15 commonly candidate five...
Abstract Background The C‐reactive protein/albumin (CRP/Alb) ratio has been recently established as a prognostic indicator in various cancer types. However, few reports regarding the value of CRP/Alb head and neck exist. This study aimed to investigate significance clinical outcomes after invasive surgery involving laryngectomy for hypopharyngeal laryngeal cancer. Methods We evaluated 56 patients who underwent total or pharyngolaryngectomy between 2003 2012. Univariate multivariate analyses...
Abstract Background The prelacrimal approach, termed endoscopic modified medial maxillectomy (EMMM), has recently been applied for treatment of inverted papilloma (IP) in the maxillary sinus. EMMM provides wider access to sinus while preserving inferior turbinate and nasolacrimal duct. Methods We reviewed patients with IP compare surgical results obtained by conventional surgery (ie, antrostomy or combination Caldwell‐Luc approach) those EMMM. Results All had a T3 on Krouse staging system,...
A near loss of smell may result from conductive and/or neural olfactory disorders. However, an test to selectively detect disorders has not been established. We investigated whether onset latency sensory response intravenous odor injection can in humans and mice. showed that longer preoperative recognition patients with chronic rhinosinusitis predicted worse recovery symptoms following sinus surgery. The the neuron (OSN) using synaptopHluorin signals OSN axon terminals was delayed mice...
Loss of olfactory sensory neurons (OSNs) after injury to the epithelium (OE) triggers generation OSNs that are incorporated into circuits restore perception. This study addresses how insulin receptor-mediated signaling affects functional recovery OE injury. Insulin levels were reduced in mice by ablating pancreatic β cells via streptozotocin (STZ) injections. These STZ-induced diabetic and control then intraperitoneally injected with olfactotoxic drug methimazole selectively ablate OSNs. The...
Food processing greatly contributed to increased food safety, diversity, and accessibility. However, the prevalence of highly palatable processed in our modern diet has exacerbated obesity rates a global health crisis. While accumulating evidence suggests that chronic consumption such foods is detrimental sensory neural physiology, it unclear whether its short-term intake adverse effects. We assessed how (<2 months) three diets varying composition macronutrient content influence olfaction...
Background A staging system is essential for determining the optimal surgical approach and predicting postoperative outcomes inverted papilloma (IP). Although systems based on extent to which location occupied by an IP have been widely used, origin site-based classification of using unsupervised machine learning algorithms has recently reported. Objective To determine most appropriate five sinonasal comparing recurrence rates each stage according those systems. Methods Eighty-seven patients...
Insulin is present in nasal mucus and plays an important role the survival activity of individual olfactory sensory neurons (OSNs) via insulin receptor-mediated signaling. However, it unclear whether acts prophylactically against olfactotoxic drug-induced epithelium (OE) injury, degree damage affected by concentration mucus. The apoptosis-inducing drug methimazole was administered to diabetic normal mice along with different concentrations insulin. Immunohistochemical analysis used assess...
Despite the use of surgical navigation systems in endoscopic sinus surgery (ESS), complications are still reported. Surgical outcome can be improved through provision adequate support for skills learning. The objectives this study were to construct a system capable automatically providing clear skill evaluation result and assess extent which our could observe residents’ learning curve. We used clinical data from image-guided ESS obtained system, included tip position rod orientation...
To present the utility of recently introduced Maniceps septum stitch device for suturing nasal septum.This paper describes techniques using following septoplasty to prevent post-operative complications such as haematoma and perforation.Nasal appears be a safe easy surgical procedure help may reduce incidence perforation septoplasty.
Objectives: Yellow nail syndrome (YNS) is a rare disease of unknown cause characterized by the triad yellow nails, respiratory manifestations, and lymphedema. Although several therapies for YNS have been reported, there no common consensus in treatment. In this case report, we present 56-year-old woman with YNS, whose manifestation was dramatically improved after endoscopic sinus surgery treatment chronic rhinosinusitis. Methods: Endoscopic involving middle meatal antrostomy performed...
A high level of surgical skill is required for endoscopic sinus surgery (ESS), a procedure that involves the nasal sinus, which adjacent to important organs, without injury. However, it difficult assess such quantitatively in clinical environment. Thus, we employed navigation system currently used ESS, and have developed method tasks by utilizing as recording medium. Previously, had analyzing manipulation an endoscope, aspect using this system, based on simulated surgeries. Here, established...
Endoscopic sinus surgery is a common procedure for chronic sinusitis; however, complications have been reported in some cases. Improving surgical outcomes requires an improvement surgeon's skills. In this study, we used workflow analysis to automatically extract "errors," indicating whether there was large difference the comparative evaluation of procedures performed by experts and residents. First, quantified features using log data, which contained instrument information (e.g., tip...
Endoscopic sinus surgery (ESS) has been performed with a navigation system to reduce risk of causing injuries and complications during the surgery. However, supporting improvement surgeons’ skill levels is important further improve safety ESS. We previously developed method for analyzing evaluating motion forceps glioma laparoscopic cholecystectomy in order help surgeons learn surgical skills. As surgeon need operate an endoscopic camera case ESS, we focused on operation. Therefore, this...
Abstract Loss of olfactory sensory neurons (OSNs) after injury to the epithelium (OE) triggers generation OSNs that are incorporated into circuits restore perception. This study addresses how insulin receptor-mediated signaling affects functional recovery OE injury. Insulin levels were reduced in mice by ablating pancreatic beta cells via streptozotocin injections. These streptozotocin-induced diabetic and control then intraperitoneally injected with olfactotoxic drug methimazole selectively...
副甲状腺機能亢進症の唯一の治療は病的副甲状腺の摘出である。近年，検診などで偶発的に発見される原発性副甲状腺機能亢進症や，透析治療の合併症である二次性副甲状腺機能亢進症が増加傾向にある。今回われわれは当科で過去2年間に経験した副甲状腺機能亢進症手術症例29例に対して病的副甲状腺の局在につき頸部超音波検査やcomputed tomography (CT)，technetium 99m 2-methoxyisobutyl-isonitrile scintigraphy (MIBIシンチ) など術前画像診断の正診率や，術後合併症として近年問題となっているhungry bone syndromeの予測因子等につき検討した。その結果，各術前画像診断の有用性が確認され特に頸部超音波検査とMIBIシンチを組み合わせることにより90％以上の高い局在診断率が得られた。また，hungry syndrome合併の予測因子として今回の術前評価項目 (血清アルカリフォスファターゼ，血清尿素窒素，年齢，術前後でのインタクトPHT減少率) の中では血清アルカリフォスファターゼの高値のみが予測因子となりうる可能性が示唆された。
ABSTRACT The prevalence of highly-palatable, ultra-processed food in our modern diet has exacerbated obesity rates and contributed to a global health crisis. While accumulating evidence suggests that chronic consumption semi-synthetic is detrimental sensory neural physiology, it unclear whether its short-term intake adverse effects. Here, we assessed how (<2 months) three diets (one grain-based diet, two semi-synthetic) influence olfaction brain metabolism mice. Our results demonstrate...