A5076755372- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- HIV Research and Treatment
- Electrochemical Analysis and Applications
- Public Health in Brazil
- Neurotransmitter Receptor Influence on Behavior
- RNA regulation and disease
- Mental Health Research Topics
- Epilepsy research and treatment
- Analytical chemistry methods development
- Radiomics and Machine Learning in Medical Imaging
- Parkinson's Disease Mechanisms and Treatments
- Chemokine receptors and signaling
- Immune cells in cancer
- Herpesvirus Infections and Treatments
- S100 Proteins and Annexins
University Medical Center Groningen
2016-2022
University of Groningen
2016-2022
Pontifícia Universidade Católica do Rio Grande do Sul
2014-2018
Instituto do Cérebro
2017-2018
Evidence suggests that exercise can modulate neuroinflammation and neuronal damage. We evaluated if such effects of be detected with positron emission tomography (PET) in a rat model Parkinson’s disease (PD). Rats were unilaterally injected the striatum 6-hydroxydopamine (PD rats) or saline (controls) either remained sedentary (SED) forced to three times per week for 40 min (EX). Motor cognitive functions by open field, novel object recognition, cylinder tests. At baseline, day 10 30, glial...
Summary Objective Temporal lobe epilepsy ( TLE ) is one of the most common types syndromes in world. Depression an important comorbidity epilepsy, which has been reported patients with and different experimental models epilepsy. However, there no established consensus on brain regions are associated manifestation depression Here, we investigated alterations cerebral glucose metabolism metabolic network pilocarpine‐induced rat model correlated it depressive behavior during chronic phase...
<sup>11</sup>C-PBR28 is a second-generation translocator protein (TSPO) tracer with characteristics supposedly superior to the most commonly used for neuroinflammation, (<i>R</i>)-<sup>11</sup>C-PK11195. Despite its use in clinical research, no studies on imaging properties and pharmacokinetic analysis of rodent models neuroinflammation have been published yet. Therefore, this study aimed evaluate as tool detection quantification preclinical research compare The herpes simplex encephalitis...
[ 11 C]UCB-J is a novel radioligand that binds to synaptic vesicle glycoprotein 2A (SV2A). The main objective of this study was determine the 28-day test–retest repeatability (TRT) quantitative brain positron emission tomography (PET) imaging in Alzheimer’s disease (AD) patients and healthy controls (HCs). Nine HCs eight AD underwent two 60 min dynamic PET scans with arterial sampling an interval 28 days. optimal tracer kinetic model assessed using Akaike criteria (AIC)....
Psychosocial stress is a risk factor for the development of depression. Recent evidence suggests that glial activation could contribute to depressive-like behaviour. This study aimed evaluate in vivo whether repeated social defeat (RSD) induces short- and long-term inflammatory metabolic alterations brain through positron emission tomography (PET). Male Wistar rats ( n = 40) were exposed RSD by dominant Long-Evans on five consecutive days. Behavioural biochemical assessed at baseline, day...
Abstract [ 11 C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, may serve as an in vivo marker of synaptic integrity. The main objective this study was evaluate quantitative accuracy and 28-day test–retest repeatability (TRT) various parametric methods for dynamic studies Alzheimer’s disease (AD) patients healthy controls (HC). Eight HCs seven AD underwent two 60-min scans with arterial sampling over interval. Several plasma-input based...
Background: Individuals at 80 years of age or above with exceptional memory are considered SuperAgers (SA), an operationalized definition successful cognitive aging. SA showed increased thickness and altered functional connectivity in the anterior cingulate cortex as a neurobiological signature. However, their metabolic alterations yet to be uncovered. Objective: Herein, (FDG-PET), amyloid (PIB-PET), (fMRI) analysis were conducted. Methods: Ten SA, ten age-matched older adults (C80),...
O objetivo do estudo foi desenvolver e validar um método de rotina para a determinação específica Sn 2+ em kits radiofármacos 2-metóxi isobutil isonitrila (MIBI).Para análise, utilizado o equipamento analisador voltamétrico.Experimentos triagem mostraram que eletrólito HCl 1 mol L -1 apresentou os melhores resultados entre todas as soluções testadas.Experimentos estabilidade declínio gradual na corrente no MIBI, 23 dias depois da preparação solução, desapareceu.Para confirmar seletividade...
Abstract Individuals at 80 years of age or above with exceptional memory are considered SuperAgers (SA). A multimodal brain analysis SA may provide biomarkers successful cognitive aging. Herein, a molecular (PET-FDG, PET-PIB), functional (fMRI) and structural (MRI) was conducted. Ten SA, ten age-matched older adults (C80) cognitively normal middle-aged underwent testing neuroimaging examinations. The relationship between scores cingulate areas hippocampus were examined. group showed...
[11C]UCB-J is a novel radioligand that binds to synaptic vesicle glycoprotein 2A (SV2A) present in neuronal presynaptic terminals. PET imaging with this should enable quantification of brain density by region and could serve as research tool clinical trials. The main objective study determine the test-retest repeatability (TRT) quantitative healthy Alzheimer's Disease (AD) subjects over 28 days. This enrolling approximately 10 AD 50 80 years old. Each subject undergoes two 60–90 minute...