A5103207936- Caveolin-1 and cellular processes
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Cancer Research and Treatments
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- Mass Spectrometry Techniques and Applications
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cholesterol and Lipid Metabolism
- Bone health and treatments
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- CAR-T cell therapy research
Baylor College of Medicine
2000-2025
The University of Texas MD Anderson Cancer Center
2010-2024
Society of Thoracic Surgeons
2018
Michael E. DeBakey VA Medical Center
2011
The University of Texas at Austin
2011
Thoracic Surgery Foundation
1996
Howard Hughes Medical Institute
1992-1996
Petersburg Nuclear Physics Institute
1989-1993
Russian Academy of Sciences
1989-1993
Research Institute of Obstetrics and Gynecology named after D.O. Ott
1991
Caveolin 1 (Cav-1) is a plasma membrane-associated protein with the capacity to modulate signaling activities in context-dependent fashion. Interactions between Cav-1 and low-density lipoprotein receptor-related 6 (LRP6) were reported be important for regulation of Wnt-β-catenin (β-cat) signaling. also interacts insulin IGF-I receptors (IGF-IR/IR) can stimulate IR kinase activities. We found positive correlation LRP6 expression both human primary prostate cancer metastasis tissues PC-3...
Caveolin, a major structural component of specialized plasma membrane invaginations (caveolae) that participate in diverse cellular activities, has been implicated the pathogenesis several human diseases, including cancer. We showed earlier studies caveolin-1 (cav-1) is consistently and strongly overexpressed metastatic prostate cancer secreted biologically active form by virulent cells. Using both vitro vivo model systems, we now present evidence supporting proangiogenic role for cav-1...
Phenylketonuria (PKU) is an autosomal recessive genetic disorder caused by phenylalanine hydroxylase (PAH) deficiency. Individuals afflicted with PKU develop irreversible mental retardation that can be largely prevented the administration of a low-phenylalanine diet. A number restriction fragment-length polymorphisms (RFLPs) have been identified in PAH gene. Combinations RFLPs constitute unique haplotypes used to identify mutant chromosomes for prenatal diagnostic purpose families....
Abstract Glioma pathogenesis-related protein 1 (GLIPR1), a novel p53 target gene, is down-regulated by methylation in prostate cancer and has p53-dependent -independent proapoptotic activities tumor cells. These properties suggest an important suppressor role for GLIPR1, yet direct genetic evidence of function GLIPR1 lacking the molecular mechanism(s), through which exerts its functions, not been shown. Here, we report that expression significantly reduced human tissues compared with...
Beckwith-Wiedemann syndrome (BWS) is a human stem cell disorder, and individuals with this disease have substantially increased risk (~800-fold) of developing tumors. Epigenetic silencing β2-spectrin (β2SP, encoded by SPTBN1), SMAD adaptor for TGF-β signaling, causally associated BWS; however, role deficiency in BWS-associated neoplastic transformation unexplored. Here, we reported that double-heterozygous Sptbn1+/- Smad3+/- mice, which defective develop multiple tumors are phenotypically...
Abstract We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to human had been brain cancers termed RTVP-1 or GLIPR. In this report, we document the is also regulated by p53 induces apoptosis cell lines. show expression of down-regulated specimens compared with normal tissue at mRNA protein levels. further epigenetic changes consistent being tumor suppressor cancer.
Previously we reported caveolin-1 (Cav-1) overexpression in prostate cancer cells and showed that it promotes progression. Here, report Cav-1 was overexpressed 41.7% (15 of 36) human high-grade prostatic intraepithelial neoplasia (HGPIN) specimens obtained during radical prostatectomies. Positive correlations exist between Cav-1-positive (Cav-1(+)) HGPIN Cav-1(+) primary (rho = 0.655, P < 0.0001) c-Myc expression 0.41, 0.032). To determine whether cooperates with development premalignant...
We identified a novel mouse gene, mRTVP-1, as p53 target gene using differential display PCR and extensive promoter analysis.The mRTVP-1 protein has 255 amino acids differs from the human RTVP-1 (hRTVP-1) by two short in-frame deletions of nine acids.RTVP-1 mRNA was induced in multiple cancer cell lines adenovirus-mediated delivery gamma irradiation or doxorubicin both presence absence endogenous p53.Analysis expression nontransformed transformed cells further supported p53-independent...
Abstract Caveolin-1 (cav-1) and the cancer-promoting growth factors vascular endothelial factor (VEGF), transforming β1 (TGF-β1), fibroblast 2 (FGF2) are often found to be upregulated in advanced prostate cancer other malignancies. However, relationship between cav-1 overexpression upregulation remains unclear. This report presents, our knowledge, first evidence that cells, a positive autoregulatory feedback loop is established which VEGF, TGF-β1, FGF2 upregulate cav-1, expression, turn,...
Endoscopic mucosal resection (EMR) is a diagnostic and potentially therapeutic option for patients with submucosal esophageal adenocarcinoma. However, there are significant concerns regarding the risk of lymph node metastasis. Our purpose was to construct comparative effectiveness analysis comparing recurrence patterns after EMR or esophagectomy.Patients who underwent esophagectomy from 2007 2015 pathologically staged adenocarcinoma were identified departmental database. Cancer-related...
Abstract Previously, we reported that caveolin-1 (cav-1) is overexpressed in metastatic prostate cancer and virulent cells secrete biologically active cav-1. We also showed cav-1 expression leads to prosurvival activities through maintenance of activated Akt taken up by other cav-1–negative tumor and/or endothelial cells, leading stimulation angiogenic PI-3-K-Akt-eNOS signaling. To analyze the functional consequences overexpression on development progression vivo, generated PBcav-1...
Downregulation of the proapoptotic p53 target gene glioma pathogenesis-related protein 1 (GLIPR1) occurs frequently in prostate cancer, but functional meaning this event is obscure. Here, we report discovery relationship between GLIPR1 and c-Myc cancer where often upregulated. We found that expression were inversely correlated human cancer. Restoration cells downregulated c-myc levels, inhibiting cell-cycle progression. was linked to a reduction β-catenin/TCF4-mediated transcription gene,...
In this study we report that expression of glioma pathogenesis‐related protein 1 (GLIPR1) regulated numerous apoptotic, cell cycle, and spindle/centrosome assembly‐related genes, including AURKA TPX2, induced apoptosis and/or mitotic catastrophe (MC) in prostate cancer (PCa) cells, p53‐mutated/deleted, androgen‐insensitive metastatic PCa cells. Mechanistically, GLIPR1 interacts with heat shock cognate 70 (Hsc70); interaction is associated SP1 c‐Myb destabilization suppression SP1‐...
GLIPR1 is upregulated by p53 in prostate cancer cells and has preclinical antitumor activity. A phase I clinical trial was conducted to evaluate the safety activity of neoadjuvant intraprostatic injection expressing adenovirus for intermediate or high-risk localized before radical prostatectomy (RP).Eligible men had (T1-T2c) with Gleason score greater than equal 7 prostate-specific antigen 10 ng/mL more were candidates RP. Patients received adenoviral vector gene a single into followed four...