A5101778505- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Trace Elements in Health
- Acute Myocardial Infarction Research
- Spine and Intervertebral Disc Pathology
- Blood Pressure and Hypertension Studies
- Ovarian cancer diagnosis and treatment
- Cardiac Imaging and Diagnostics
- Nutritional Studies and Diet
- Coronary Interventions and Diagnostics
- Angiogenesis and VEGF in Cancer
- Orthopedic Surgery and Rehabilitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- Veterinary Equine Medical Research
- Sarcoma Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Cardiac Arrhythmias and Treatments
- Sodium Intake and Health
- Advanced Fluorescence Microscopy Techniques
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cardiovascular Issues in Pregnancy
- Uterine Myomas and Treatments
- Hemodynamic Monitoring and Therapy
- Optical Imaging and Spectroscopy Techniques
Colorado State University
2012-2024
Korea Advanced Institute of Science and Technology
2023
Korea Institute of Brain Science
2023
Finnish Food Authority
2023
Norwegian Veterinary Institute
2023
Inje University Haeundae Paik Hospital
2019-2022
Hallym University
2018-2021
Hangang Sacred Heart Hospital
2018-2021
Seoul National University Bundang Hospital
2016-2019
Seoul National University
2017
Our previous studies using gene-targeted mouse models of chronic wasting disease (CWD) demonstrated that Norway and North America cervids are infected with distinct prion strains respond differently to naturally occurring amino acid variation at residue 226 the protein. Here we performed transmissions in mice investigate properties prions causing newly emergent CWD moose Finland. Although from Finland had comparable responses primary structural differences 226, other distinctive criteria,...
Significance To study mechanisms of interspecies prion transmission, we used transgenic mice that recapitulate natural disease susceptibilities. Predictably, prions from a particular species inefficiently caused in expressing proteins different species. However, contrast to the expected adaptation allows efficient replication new host, discovered process which pathogenic prions, despite causing on primary passage, failed adapt for sustained propagation instead preserving strain and host...
Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption host protein (PrP) to its infective counterpart, contagious transmission chronic wasting disease (CWD) results from shedding prions produced at high titers in periphery diseased cervids. While deer and elk PrP primary structures are equivalent except residue 226, which glutamate glutamine deer, effect this difference on CWD pathogenesis largely unknown. Using a gene-targeting...
Since prion diseases result from infection and neurodegeneration of the central nervous system (CNS), experimental characterizations strain properties customarily rely on outcomes intracerebral challenges. However, natural transmission certain prions, including those causing chronic wasting disease (CWD) in elk deer, depends propagation peripheral host compartments prior to CNS infection. Using gene-targeted GtE GtQ mice, which accurately control cellular or deer PrP expression, we assessed...
ERG, a member of the ETS family transcription factors, is highly specific endothelial marker. We investigated whether use ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis.Fifteen cases surgically resected colorectal cancers with hepatic metastasis were selected most representative sections for detection immunostained CD31, D2-40. Eight independently evaluated status on hematoxylin eosin (H&E) corresponding...
Whereas prion replication involves structural rearrangement of cellular protein (PrP(C)), the existence conformational epitopes remains speculative and controversial, PrP transformation is monitored by immunoblot detection PrP(27-30), a protease-resistant counterpart pathogenic scrapie form (PrP(Sc)) PrP. We now describe involvement specific amino acids in determinants novel monoclonal antibodies (mAbs) raised against randomly chimeric Epitope recognition two mAbs depended on polymorphisms...
Statins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicardial adipose tissue (EAT) refers to the visceral fat surrounding heart, which is associated metabolic diseases. We sought determine EAT thickness NODM CAD treated high-intensity statins.We conducted a retrospective medical record review statins at least 6 months after percutaneous...
In patients with colorectal cancer (CRC), the BRAF V600E mutation has been reported to be associated several clinicopathological features and poor survival.However, prognostic implications of characteristics in CRCs remain controversial.Therefore, we reviewed various features, including status, 349 primary analyzed relationship between status factors, overall survival.Similar previous studies conducted Eastern countries, incidence current study was relatively low (5.7%).BRAF-mutated CRC...
Although they share certain biological properties with nucleic acid based infectious agents, prions, the causative agents of invariably fatal, transmissible neurodegenerative disorders such as bovine spongiform encephalopathy, sheep scrapie, and human Creutzfeldt Jakob disease, propagate by conformational templating host encoded proteins. Once thought to be unique these diseases, this mechanism is now recognized a ubiquitous means information transfer in systems, including other protein...
Background Arterial access and hemostasis are important processes during percutaneous coronary procedures. In this study, we tested if the use of chitosan-based pads on top compression devices could improve efficacy compared with alone after transradial angiography or interventions. Methods This study was a single-center open-label randomized controlled trial. Patients who underwent intervention approach were randomly assigned to (compression device pad) control alone) group in 2:1 fashion....
The causative factors underlying conformational conversion of cellular prion protein (PrPC) into its infectious counterpart (PrPSc) during infection remain undetermined, in part because a lack monoclonal antibodies (mAbs) that can distinguish these isoforms. Here we show the anti-PrP mAb PRC7 recognizes an epitope is shielded from detection when glycans are attached to Asn-196. We observed whereas PrPC predisposed full glycosylation and therefore refractory detection, leads diminished PrPSc...
The prevalence, host range and geographical bounds of chronic wasting disease (CWD), the prion cervids, are expanding. Horizontal transmission likely contributes majority new CWD cases, but mechanism by which prions transmitted among CWD-affected cervids remains unclear. To address extent to amplification in peripheral tissues contagious transmission, we assessed levels central nervous lymphoreticular system white-tailed deer (Odocoileus virginianus), red (Cervus elaphus elaphus) elk...
We evaluated p53, KRAS , BRAF and CTNNB 1 mutation WT 1, p16 beta‐catenin expression in 31 ovarian high‐grade serous adenocarcinoma. Twenty‐five (80.6%) tumors contained functional mutations of p53 ; three frameshift, four nonsense 19 missense mutations. None the showed or mutation. In all 18 with mutations, ≥60% tumor cells were strongly positive for immunostaining whereas frameshift completely negative. Missense was correlated diffuse strong imunoreaction frameshift/nonsense negative...
Abstract Background Preeclampsia is associated with increased arterial stiffness during pregnancy. However, data on the longitudinal change in after delivery women preeclampsia are lacking. In this pilot study, we aimed to examine using cardio-ankle vascular index preeclamptic and normotensive pregnancies. Methods We enrolled pregnant ( n = 37) normotension 36) who gave birth at Seoul National University Bundang Hospital between March 2013 May 2016, followed-up day 1, 6 months, 12 months...
Secondhand smoke exposure (SHSE) in nonsmokers has been associated with premature cardiovascular mortality and ischemic heart disease. We conducted a cross-sectional, population-based study evaluating the relationship between SHSE, measured by subjective objective methods, conventional risks such as blood pressure, lipid profiles, fasting glucose.We extracted information on 7376 healthy adults who had never smoked, for whom there were available urine cotinine levels, from Korea National...
To determine whether olecranon fractures have osteoporotic features such as age-dependent, low bone attenuation and low-energy trauma a cause of injury.Elbow computed tomography (CT) medical record review were performed in 114 patients (53 males 61 females) with acute fractures. The mean age was 57 years. Bone measured on the central part sagittal CT images avoiding fracture, distal humerus (distal metaphysis medial lateral condyles) coronal images. We compared causes injury (high or energy...
Background/Aims To examine the prevalence and clinical characteristics of apparent treatment-resistant hypertension among ambulatory hypertensive patients. Methods We enrolled adult patients at 13 well-qualified general hospitals in Korea from January to June 2012. Apparent resistant was defined as an elevated blood pressure > 140/90 mmHg with use three antihypertensive agents, including diuretics, or ≥ 4 antihypertensives, regardless pressure. Controlled a within target using diuretics....
Objective Activated platelets release serotonin, causing platelet aggregation and vasoconstriction. Serotonin levels were investigated in patients with acute coronary syndrome (ACS) chronic stable angina (CSA) treated percutaneous intervention (PCI). Methods Consecutive undergoing PCI for either ACS or CSA enrolled between July 2009 April 2010. Patients pre-treated dual antiplatelet agents (aspirin clopidogrel) before PCI. Serum serotonin levels, measured at baseline, pre- post-PCI, 90 min,...
Background and objectives: The purpose of this study was to compare analyze contrast spread patterns between the paramedian midline approaches cervical interlaminar epidural injection (CIEI). Materials Methods: We retrospectively enrolled 84 CIEI cases that had been performed for unilateral spinal pain from April 2019 2020. After 3 mL injected into space, fluoroscopic images were obtained. divided a (Group M, n = 42) P, approach by anteroposterior imaging. P Group classified more medial Pm,...
Malignant changes in struma ovarii have been defined using histopathologic criteria for carcinomas of the cervical thyroid gland. We report a case with extensive extraovarian spread containing small focus anaplastic carcinoma (AC) peritoneal implants. AC arising benign-looking implants has not reported. Multiple pelvic masses were identified on abdominopelvic computed tomography 38-yr-old woman. An exploratory laparotomy revealed multiple, variable-sized omentum, and colonic uterine serosa....
Background/Aims Currently, office blood pressure (OBP) is the most widely used method of measuring (BP) in daily clinical practice. However, data on diagnostic accuracy OBP reference to ambulatory (ABP) are scarce Korea. Methods In retrospective and prospective cohorts, manual ABP measurements were compared among hypertensive patients. Hypertension was defined as systolic ⥠140 mmHg and/or diastolic 90 mmHg, 130 80 mmHg. Results cohort (n = 903), mean OBP1 (before measurement) higher than...