A5102829659- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Plant Reproductive Biology
- Enzyme Structure and Function
- Alzheimer's disease research and treatments
- Trace Elements in Health
Colorado State University
2012-2021
University of Kentucky
2011-2013
Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of animals and humans. Replication involves template-directed refolding host encoded prion protein, PrP C , by its conformation, Sc . Following discovery in captive Colorado deer 1967, uncontrollable contagious transmission chronic wasting disease (CWD) led to an expanded geographic range increasing numbers free-ranging North American (NA) cervids. Some five decades later, detection Norwegian (NO) reindeer...
Whereas prion replication involves structural rearrangement of cellular protein (PrP(C)), the existence conformational epitopes remains speculative and controversial, PrP transformation is monitored by immunoblot detection PrP(27-30), a protease-resistant counterpart pathogenic scrapie form (PrP(Sc)) PrP. We now describe involvement specific amino acids in determinants novel monoclonal antibodies (mAbs) raised against randomly chimeric Epitope recognition two mAbs depended on polymorphisms...
Although they share certain biological properties with nucleic acid based infectious agents, prions, the causative agents of invariably fatal, transmissible neurodegenerative disorders such as bovine spongiform encephalopathy, sheep scrapie, and human Creutzfeldt Jakob disease, propagate by conformational templating host encoded proteins. Once thought to be unique these diseases, this mechanism is now recognized a ubiquitous means information transfer in systems, including other protein...
The suggested role of cellular prion protein (PrP (C) ) in mediating the toxic effects oligomeric amyloid β peptide (Aβ) Alzheimer disease (AD) is controversial. To address hypothesis that variable PrP expression involved AD pathogenesis, we analyzed PrPC frontal and temporal cortices hippocampus individuals with no cognitive impairment (NCI), amnestic mild (aMCI), (mAD), AD. We found all brain regions was not significantly altered among various patient groups. In addition, levels groups did...