Background. The World Health Organization recommends that infants at high risk for developing measles before 9 months of age, including human immunodeficiency virus (HIV)-infected infants, receive vaccination (MV) 6 and age.

Background and Objectives: Some patients with Kawasaki disease (KD) present fever cervical lymphadenopathy alone.The purpose of this study was to characterize the clinical features these unusual KD determine whether is a severe form associated increased risks intravenous immunoglobulin (IVIG) resistance coronary artery lesions (CALs).Subjects Methods: A total 146 children were reviewed retrospectively, classified into two groups according initial features.Those presenting only (LKD) as LKD...

Background: Anemia and transfusion are predictors of disease progression in AIDS patients. This study was designed to examine the effects blood on human immunodeficiency virus type 1 (HIV‐1) expression. Study Design Methods: Assays plasma viral load were performed before after nine HIV‐1‐infected patients who required for refractory anemia. Results: There a modest rise HIV‐1 p24 antigen RNA beginning 2 weeks transfusion. The mean change all 9.3 ± 5.1 (mean SE) pg per mL at Week 18 11.1 4....

Schisandra chinensis (SC), a member of the Magnoliaceae family, has been used to improve vascular health for postmenopausal women in Korea. In order provide some scientific rationales such effectiveness, this study investigated effects gomisin A (GA) from SC. endothelium (ED)-intact rings rat thoracic aorta, GA (1 × 10-6 3 10-4 M) caused concentration-dependent relaxation which was markedly attenuated not only by removal ED but also pretreatment with N G-nitro-L-arginine (10-4 or 1H-[1] [2]...

Purpose To evaluate the long-term safety of polyethylene glycol (PEG) 4000 in children with constipation, particularly biochemical aspects safety. Methods Medical records were evaluated, and 100 children, who had been taking PEG for more than 6 months, under clinical monitoring, enrolled. Ages; 6.11±3.12 years, Duration therapy; 16.93±7.02 dose 4000; 0.72±0.21 g/kg/d. Results None complained adverse effect. The first test was performed at 8.05 months after beginning 4000. Serum phosphate...

A fecaloma refers to a mass of accumulated feces that is much harder than associated with fecal impaction. Fecalomas are usually found in the rectosigmoid area. 10-year-old male chronic constipation was admitted because increasing abdominal pain. An computed tomography scan and simple x-ray revealed rapidly evolving mechanical obstruction small intestine. Most fecalomas successfully treated by conservative methods such as laxatives, enemas rectal evacuation. When treatments have failed,...

Our aim was to determine whether the index of left ventricular mass increases during acute and subacute phase Kawasaki disease, investigate any relationship between this clinical echocardiographic variables. We performed, therefore, a retrospective study 66 children with having mean age 2.85 years, comparing findings those obtained from 57 normal controls, 2.99 years. The data patients used for comparison illness, as well convalescence. performed correlation analysis phase, determining other...

The aim of the present study was to evaluate effect fluid intake on outcome treatment with osmotic laxatives, PEG 4000 and lactulose, in children chronic constipation.Medical records were reviewed, 27 constipation satisfying following criteria enrolled: (i) stable maintenance medication for ≥ 3 months; (ii) no dosage modification or drug change between two periods compared; (iii) clinical events during investigation that could affect outcomes; (iv) good compliance regarding inclusion diaries...

Each ethnic group has a unique life style, including diets. Life style affects bowel movement. The aim of this study is to describe the results colon transit time (CTT) tests in Korean children who had chronic functional constipation based on highly refined data.One hundred ninety (86 males) out 415 performed CTT test under diagnosis according Rome III criteria at Konkuk University Medical Center from January 2006 through March 2015 were enrolled study. Two hundreds twenty-five excluded...

Shwachman-Diamond syndrome (SDS) is an autosomal recessive genetic disorder, consisting of exocrine pancreatic insufficiency, chronic neutropenia, neutrophil chemotaxis defects, metaphyseal dysostosis, short stature, dental caries, and multiple organ involvements. Although SDS the second most common hereditary abnormality pancreas following cystic fibrosis in Western countries, it has rarely been reported Asia. We diagnosed a case 42-month-old girl, analysis including relatives patient...

Translationally controlled tumor protein (TCTP), a repressor for Na,K-ATPase has been implicated in the development of systemic hypertension, as proved by TCTP-over-expressing transgenic (TCTP-TG) mice. Aorta TCTP-TG exhibited hypercontractile response compared to that non-transgenic mice (NTG) suggesting dys-regulation signaling pathways involved vascular contractility TCTP. Because RhoA/Rho kinase pathway is increased contractility, we examined whether TCTP induces alterations RhoA smooth...

Purpose: To compare the clinical features, diagnostic findings, and medications of children with infrequent bowel movements or fecal soiling.Methods: This study enrolled 333 (189 male; age range, 1 month to 18 years) diagnosed functional constipation by Rome III IV criteria.We classified them into 3 groups (infrequent movement without soiling [G3-a], [G3-b], only [G3-c]) 2 subgroups (G2-b) not (G2-a).Retrospective data on characteristics, colon transit time (CTT) test results, were...

Purpose : The identification of specific behaviors conducive to overeating or inactivity is the cornerstone obesity management. Committee on Nutrition Korean Pediatric Society developed parent and self-reporting questionnaires about eating behavior physical activity in 2006. aim this study was evaluate usefulness assessing modifiable lifestyle factors related obesity. Methods A retrospective chart review performed for 177 children (6-11 years old) 134 adolescents (12-16 from 10 hospitals...

Menkes disease is an infantile-onset X-linked recessive neurodegenerative disorder caused by diverse mutations in a copper-transport gene, ATP7A.Affected patients are characterized progressive hypotonia, seizures, failure to thrive and death early childhood.Here, we report case of presented intractable seizures infantile spasms.A 3-month-old male infant had visited our pediatric clinic for lethargy, floppy muscle tone, poor oral intake partial seizures.His hair was kinky, brown colored...

Omega (ω)-3 polyunsaturated fatty acids appear to be effective in preventing and treating parenteral nutrition-associated liver disease, several mechanisms were proposed for this observation. An 8-week-old male infant with cholestasis acholic stool was diagnosed non-syndromic intrahepatic interlobular bile duct paucity by open-wedge biopsy. Initially he treated usual supportive medical therapy, including ursodeoxycholic acid. However, the clinical status laboratory tests did not improve....

Background/Aims: Wilson's disease (WD) is an inherited disorder of copper metabolism caused by alteration the P-type adenosine triphosphatase (ATP) 7B gene.In this study, we analyzed frequency well-known mutations and constructed first haplotypes for Koreans.In addition, evaluated whether a founder effect existed in Korean patients with WD.Methods: We obtained DNA samples from 21 WD their parents (total cohort n=63).ATP7B gene were identified direct sequencing methods, microsatellite typing...

We evaluated the efficacy and safety of combined oral enema therapy using polyethylene glycol (PEG) 3350 with electrolyte solution for disimpaction in hospitalized children.We retrospectively studied 28 children having functional constipation who received inpatient treatment between 2008 2016. The amount PEG administered was 50-70 mL/kg/d (PEG 3350, 3-4.1 g/kg/d), an 1-2 times a day as single dose 15-25 mL/kg 0.975-1.625 g/kg/d). A colon transit time (CTT) test based on Metcalf protocol...

Abstract Giant cell hepatitis (GCH) with autoimmune hemolytic anemia (AHA) is a very rare disease characterized by early onset and severe clinical manifestations, including immune cholestasis. The prognosis poor despite aggressive immunosuppressive therapy. We report here the first case of GCH AHA in East Asia. A 2‐month‐old boy was admitted jaundice. Blood test indicated abnormal liver function low hemoglobin. Direct Coombs several autoantibodies associated were positive, biopsy consistent...

Barth syndrome (BTHS) is a rare genetic disorder characterized by various types of cardiomyopathy, neutropenia, failure to thrive, skeletal myopathy, and 3-methylglutaconic aciduria. BTHS caused loss-of-function mutations in the tafazzin (TAZ) gene located on chromosome Xq28, leading cardiolipin deficiency. We report 13-month-old boy with who had novel de novo mutation TAZ gene. To best our knowledge, this first reported case patient Korea. This will contribute towards expanding knowledge...